Preparation of Poly(3-hydroxybutyrate-b-ε-caprolactone) by Reactive Extrusion and Production of Electrospun Fibrous Mats

Sakaguti, Katia Y.; Wang, Shu Hui

doi:10.21577/0103-5053.20200186

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“…As previously stated, several natural and synthetic biocompatible polymers have been electrospun and altered to fulfill diverse applications in accordance with the particular demands of various tissues [87,88]. Polycaprolactone (PCL) as shown in )Figure 13( is biocompatible and biodegradable polymer has been formed in a fibrous structure and used for drug delivery, wound dressing, and tissue regeneration using the electrospinning method [89]. However, certain very hazardous solvents, including such chloroform, DMF, THF, and mixtures thereof, have been employed in the electrospinning of PCL in order to achieve bead-free nanoscale fibers [39,90].…”

Section: Polycaprolactone (Pcl) Nanofibersmentioning

confidence: 99%

Nanomaterials and nanofibers as wound dressing mats: An overview of the fundamentals, properties and applications

et al. 2021

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Polymeric nanofibers can simply be fabricated through an electrospinning technique. The electrospinning process is one of the best usually utilized approaches to achieve continuous fibers in the nanosized form. Electrospinning has extended attractiveness because of its ease of use, simplicity and various applications. The electrospun fibers properties could be controlled via adjusting each procedure variables such as solution flow rate, applied voltage, as well as space between charged capillary and collector) or the properties of polymeric solution for example (e.g., molecular weight, concentration, surface tension, surface charge density, viscosity, solvent volatility, and conductivity). Furthermore, the used polymeric solution can be a polymeric melt, aqueous, or an emulsion, which give opportunity to diverse sorts of nanofiber construction. Also, by polarity inversion and by varying the collector design the properties of nanofiber can be improved. Moreover, polymeric fibers can be modified by incorporated through blending, surface modification or emulsion formation. The nanofibers were modified to provide manifold drugs, as well as multilayer polymer coating lets continuous release of the combined active moiety. Electrospun nanofibers fabricated from different polymers are utilized to realize anticancer agents and antibiotic, DNA, RNA, as well as growth factors. The current review delivers a collecting of some work concerning the usage of electrospun fibers in drug delivery with a special emphasis on electrospun nanofibers impregnated with nanoparticles also electrospun nanofibers in biomedical applications such as wound dressings prevents infection and speeds up the healing process.

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Section: Polycaprolactone (Pcl) Nanofibersmentioning

confidence: 99%