2020
DOI: 10.21577/0103-5053.20200141
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Bergenin of Peltophorum dubium (Fabaceae) Roots and Its Bioactive Semi‑Synthetic Derivatives

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Cited by 4 publications
(6 citation statements)
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“…After treatment with the extract (0.3 to 30 mg/kg), the results suggested that the extract showed therapeutic action in rheumatoid arthritis and decreased the amount of inflammation through the de-accumulation of pro-inflammatory cytokines and by modulating the immune response in the cells. Bharat et al [ 122 ] came to the same conclusion using the ethanolic extract of the rhizome of bergenin-rich B. ciliata (IC 50 of 2 g/kg) in rats induced to arthritis using Mycobacterium .…”
Section: Biological and Pharmacological Activities Of Bergeninmentioning
confidence: 74%
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“…After treatment with the extract (0.3 to 30 mg/kg), the results suggested that the extract showed therapeutic action in rheumatoid arthritis and decreased the amount of inflammation through the de-accumulation of pro-inflammatory cytokines and by modulating the immune response in the cells. Bharat et al [ 122 ] came to the same conclusion using the ethanolic extract of the rhizome of bergenin-rich B. ciliata (IC 50 of 2 g/kg) in rats induced to arthritis using Mycobacterium .…”
Section: Biological and Pharmacological Activities Of Bergeninmentioning
confidence: 74%
“…(−), E. Proteus sp. (−), E. phaeacalis (+) and S. aureus (+) (IC 50 ranging from 3.125 to 6.25 µg/mL) [ 122 ]. Nyemb et al [ 123 ] reported that bergenin isolated from C. populnea roots had an inhibitory effect against four strains of Gram-negative bacteria in vitro: S. typhi (ATCC6539), S. typhi (isolated), P. aeruginosa (ATCC9721) and E. coli (isolated), IC 50 ranging from 8 to 64 µg/mL.…”
Section: Biological and Pharmacological Activities Of Bergeninmentioning
confidence: 99%
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“…This isocoumarin and its derivatives, such as the identified flavonoids, can be directly related to the antimicrobial activity of the extracts against S. aureus . A recent study showed that six synthetic derivatives of bergenin obtained by Williamson synthesis inhibited S. aureus growth, especially 8,10-dihexyl-bergenin and 8,10-didecyl-bergenin, which presented the most promising MIC value: 3.12 µg/mL [ 47 ].…”
Section: Discussionmentioning
confidence: 99%