Synthesis, in silico Study, Theoretical Stereochemistry Elucidation and Antifungal Activity of New Imides Derived from Safrole

Vilela, Raquel F.; Costa, Normando A. S.; Souza, Helivaldo Diógenes da Silva; Cruz, Luiz E. G. da; Assis, Kelyonara M. S. de; Lima, Edeltrudes O.; Cordeiro, Laísa Vilar; Lira, Bruno Freitas; Athayde-Filho, Petrônio Filgueiras de; Rocha, Gerd B.; Barbosa-Filho, José Maria

doi:10.21577/0103-5053.20200110

Cited by 1 publication

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“…Furthermore, piperonyl butoxide—an insecticide synergist used in a wide variety of pesticides [ 250 ]—and heliotropine (piperonal)—a fragrance substance and synthon for several drugs, including L-Dopa, tadalafil, and atrasentan—are being synthesized from safrole as a starting material [ 219 ]. Only recently, eight new imides with strong antifungal activity against various strains of Candida and Cryptococcus have been synthesized from safrole [ 251 ]. Modified collagen cross-linked with epoxidized safrole (OYBD) was found to exert excellent antibacterial activity against Gram-negative E. coli , and Gram-positive S. aureus , respectively.…”

Section: Essential Oils From Selected Rootsmentioning

confidence: 99%

Back to the Roots—An Overview of the Chemical Composition and Bioactivity of Selected Root-Essential Oils

Lunz

Stappen

2021

Molecules

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Since ancient times, plant roots have been widely used in traditional medicine for treating various ailments and diseases due to their beneficial effects. A large number of studies have demonstrated that—besides their aromatic properties—their biological activity can often be attributed to volatile constituents. This review provides a comprehensive overview of investigations into the chemical composition of essential oils and volatile components obtained from selected aromatic roots, including Angelica archangelica, Armoracia rusticana, Carlina sp., Chrysopogon zizanioides, Coleus forskohlii, Inula helenium, Sassafras albidum, Saussurea costus, and Valeriana officinalis. Additionally, their most important associated biological impacts are reported, such as anticarcinogenic, antimicrobial, antioxidant, pesticidal, and other miscellaneous properties. Various literature and electronic databases—including PubMed, ScienceDirect, Springer, Scopus, Google Scholar, and Wiley—were screened and data was obtained accordingly. The results indicate the promising properties of root-essential oils and their potential as a source for natural biologically active products for flavor, pharmaceutical, agricultural, and fragrance industries. However, more research is required to further establish the mechanism of action mediating these bioactivities as well as essential oil standardization because the chemical composition often strongly varies depending on external factors.

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Section: Essential Oils From Selected Rootsmentioning

confidence: 99%