Synthesis, Characterization, Spectroelectrochemical, Photophysical and HSA‑Binding Properties of Novel and Versatile meso-Tetra(4-pyridylvinylphenyl)porphyrins Coordinated to Ruthenium(II)-Polypyridyl Derivatives

Interactions of a Ruthenium‐Ketoprofen Compound with Human Serum Albumin and DNA: Insights from Spectrophotometric Titrations and Molecular Docking Calculations

“…[64] Thus, the in silico calculations suggested major groove of DNA strands and subdomain IB of HSA as the main binding sites for the [Ru 2 O(keto) 2 (py) 6 ](PF 6 ) 2 compound. The same trend for both DNA and HSA was previously observed in silico for some other ruthenium complexes, including Ru(II)-polypyridyl [Ru(NÀ N) 2 (PTCP)](ClO 4 ) 2 (where NÀ N : 1,10-phenanthroline; 2,9-dimethyl-1,10-phenanthroline, or 4,40-di-tert-butyl-2,20-bipyridine), [65] meso-tetra(4pyridylvinylphenyl)porphyrin functionalized with [Ru(bpy) 2 Cl] + units, [66] 10,15,20-tetrakis(4-pyridyl)-21H,23H-porphyrin functionalized with [Ru(bpy) 2 Cl] + units, [67] [Ru(tmp) 2 (dpq)] 2 + , [Ru-(tmp) 2 (dppz)] 2 + , and [Ru(tmp) 2 (11,12-dmdppz)] 2 + . [68] Aditionally, the highest docking score value for HSA compared with DNA suggested that [Ru 2 O(keto) 2 (py) 6 ](PF 6 ) 2 interacts stronger with albumin than with DNA, being in agreement with the experimental trend, as well as the experimental number of binding site indicated a proportion HSA:[Ru 2 O(keto) 2 (py) 6 ](PF 6 ) 2 of 1 : 1 and molecular docking score values for albumin clearly show a high difference among the three binding sites, also indicating one main binding site.…”

Review—Tetraruthenated Porphyrins and Composites as Catalysts and Sensor Materials: A Short Review

“…The wave at E 1/2 = +0.90 V was assigned to the Ru(III/II) process, while the waves at −0.70 and −1.05 V were assigned to the first and second mono-electronic reduction processes of the porphyrin ring. The redox process associated with the ruthenium center (+0.89 V) is not significantly affected by the coordination of Zn(II) generating the Zn-TRuPyViP species, whilst the porphyrin ring reduction processes are shifted respectively to −0.99 and −1.21 V, and the ring oxidation process to +1.43 V. 28 Another very interesting example are the supramolecular species assembled by coordination of [RuCl(5,5′-Mebpy)(dppb)] + (dppb = 1,4-bis(diphenylphosphino)butane) complexes to meso-tetra(2thienyl)-porphyrins (TThP) and meso-tetra(5-methyl-2-thienyl)-porphyrins (TMeThP) (Fig. 2).…”