Theoretical and Experimental Investigations on Inclusion Complex β-Cyclodextrin and Sulcatone: A Cardiovascular Activity Evaluation

Abstract

In this paper, we have applied state-of-the-art technologies and new investigations were developed focusing on obtaining simple and inexpensive molecules for treating cardiovascular diseases, as they are considered the leading cause of death in the world. For the first time, the inclusion complex of sulcatone (SU) and β-cyclodextrin (β-CD) was achieved (using a spray drier) and characterized making use of spectroscopic, thermal and computational methods. In addition, the system was evaluated regarding its vasorelaxant properties. Evidence of the inclusion complex formation was provided using different techniques, such as X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR), and 1 H nuclear magnetic resonance (NMR) spectroscopies and then deduced by pharmacological experiments, which showed significant changes in relation to the initial material.

Study on the preparation of geranyl acetone and β-cyclodextrin inclusion complex and its application in cigarette flavoring

“…Due to the occurrence of interactions between the guest and the CD, the DSC curves shall present a not coincident profile with the sum of the effects observed in the thermograms of the constituents 35 , as shown in Fig. 3 , β-CD has a characteristic endothermic peak at 96 °C and 271 °C correspond to the events of water loss and cyclodextrin decomposition, respectively 36 . GA has a characteristic endothermic peak at 140.5 °C, and MGA has both a characteristic peak of β-CD and a characteristic peak of GA, which is the addition of the two curves.…”