New Limonoids from Dictyoloma vandellianum and Sohnreyia excelsa: Chemosystematic Considerations

Abstract

Molecular phylogenetic studies separated and united a group of genera that constituted the Spathelia-Ptaeroxylon clade, in which Dictyoloma and Sohnreyia have been included. Our taxonomic interest in the Dictyoloma vandellianum and Sohnreyia excelsa stimulated an investigation of both species searching for limonoids. Leaves from D. vandellianum afforded the new limonoid 1,2-dihydro-1α-hydroxy-8,30-epoxy-cneorin R, and heartwood yielded the new rearranged limonoid dictyolomin. Leaves from S. excelsa afforded the new protolimonoid 3β-angeloyloxy-7α,24,25-trihydroxy-21,23-oxide-14,18-cycloapotirucall-21-methoxycetal and the new cycloheptanyl ring C limonoid with carbonate substituent and named as sohnreyolide. The new limonoids from Sohnreyia and Dictyoloma show similarities with those from Rutaceae and Meliaceae, providing support for moving Spathelia-Ptaeroxylon clade near to these associated large families.

Degraded limonoids: biologically active limonoid fragments re-enhancing interest in Meliaceae and Rutaceae sources

“…The chief sources of limonoids are the Meliaceae and Rutaceae plant families (Da Silva et al 1984; Fig. 1 Basic limonoid skeleton Champagne et al 1992;Roy and Saraf 2006;Liao et al 2009;Fang et al 2011;Sun et al 2018;Sartor et al 2019;Cui et al 2021;Luo et al 2022) but they also can be found very occasionally in Cneoracea and Ptaeroxylaceae families and Harrisonia spp. of Simaroubaceae (Ourison et al 1964;Connolly 1983;Da Silva et al 1987;Tundis et al 2014;Amit and Shailendra 2006;Tan and Luo 2011).…”