Gold Nanoparticles and [PEDOT-Poly(D,L-Lactic Acid)] Composite: Synthesis, Characterization and Application to H2O2 Sensing

Abstract

Biocompatible electrochemical devices are challenging to develop due to the toxicity of many advanced electrode materials and the difficulty to degrade the discarded material. Few recent advances were made in the synthesis of conducting biodegradable composites of polymers for electrode materials. In this article we describe the synthesis of two new inorganic/organic nanocomposites of Au nanoparticles and conducting polymers based on the biodegradable polymer poly(D,L-lactic acid) (PDLLA): Au nanoparticles/oligomers of 3,4-ethylenedioxythiophene (EDOT)-PDLLA and Au nanoparticles with poly(3,4-ethylenedioxythiophene) (PEDOT)-PDLLA. The nanocomposites were carefully analyzed; the gold nanoparticles mean sizes were 8 ± 3 and 7 ± 2 nm, respectively. 1 H and 13 C nuclear magnetic resonance (NMR) demonstrated the polymerization of EDOT-PDLLA made through one-pot reaction with Au III precursor. Raman spectra show that PEDOT-PDLLA is formed in the synthesis of Au/PEDOT-PDLLA. The immobilization of Au/PEDOT-PDLLA on glassy carbon electrodes is easy and more stable than the immobilization of simple PEDOT. Au/PEDOT-PDLLA catalyzes the reduction of H 2 O 2(aq) , which was detected by chronoamperometry. The sensor is stable and presents sensitivity of 8.36 × 10 −3 A mol −1 L cm −2 , linear range of 1-45 mmol L −1 and limit of detection of 0.17 mmol L −1 .

PEDOT-AuNPs-based impedimetric immunosensor for the detection of SARS-CoV-2 antibodies

“…In order to show that the nanocomposite was successfully electrosynthesized, Raman spectra were recorded, and the results are shown in Figure 2 . The pristine PEDOT spectrum attributions are compiled in Table S3 in supplementary material, as previously described elsewhere [67] , [68] , [69] , [70] , [71] , [72] , [73] . In our analysis, some bands stand out as the signals at 495 and 995 cm −1 associated to oxyethylene ring deformation, the band at 692 cm −1 assigned to symmetric deformation of C α -S-C α , in 1131 cm −1 related to C-O-C bond and the weak band at 1252 cm −1 attributed to C α -C α inter rings [ 67 , 70 , 71 ].…”

“…The pristine PEDOT spectrum attributions are compiled in Table S3 in supplementary material, as previously described elsewhere [67] , [68] , [69] , [70] , [71] , [72] , [73] . In our analysis, some bands stand out as the signals at 495 and 995 cm −1 associated to oxyethylene ring deformation, the band at 692 cm −1 assigned to symmetric deformation of C α -S-C α , in 1131 cm −1 related to C-O-C bond and the weak band at 1252 cm −1 attributed to C α -C α inter rings [ 67 , 70 , 71 ]. The signals centered at 1367, 1439, and 1500 cm −1 are attributed to C-C, C=C(-O) e C=C stretching, respectively [ 67 , 68 , 70 ].…”

Electrical/Spectroscopic Stability of Conducting and Biodegradable Graft‐Copolymer

“…The synthesis method was developed in previous work. [59,60,93] Briefly, the first synthesis step was to obtain an electroactive macromonomer of EDOT-PDLLA. 3,6-Dimethyl-1,4-dioxane-2,5-dione (2.76 g, 20 mmol), hydroxymethyl EDOT (100 mg, 0.6 mmol), and tin (II)-2-ethylhexanoate (0.016 mL, 0.05 mmol) were stirred at 110 °C with 7 mL of toluene for 24 h. The solvent was removed by distillation under reduced pressure (20 mBar, 60 °C).…”

Polymers Based on PLA from Synthesis Using D,L-Lactic Acid (or Racemic Lactide) and Some Biomedical Applications: A Short Review

“…It was found that PEDOT-co-PDLLA materials had properties such as surface chemistry and charge density to make them potentially useful as scaffolds. In another application with PEDOT-PDLLA, Da Silva et al, also synthesized two inorganic/organic nanocomposites of Au [140]. The gold nanoparticles (7-8 nm of mean sizes), Au/PEDOT-PDLLA were able to the reduction of H 2 O 2 in an aqueous solution with a limit of detection of 0.17 mmol/L, which makes it a promissory material for sensing.…”