A Complete and Unambiguous 1H and 13C NMR Signals Assignment of para- Naphthoquinones, ortho- and para-Furanonaphthoquinones

Abstract

A complete and unambiguous assignment of 1 H and 13 C nuclear magnetic resonance (NMR) signals of 29 naphthoquinones is reported on the basis of one-and two-dimensional NMR techniques (1 H, 13 C, 1 H-1 H correlated spectroscopy (COSY) and 1 H-13 C heteronuclear multiple-bond correlation (HMBC)). This is the first report distinguishing data between para-naphthoquinones, ortho-and para-furanonaphthoquinones isomers.

Design of Anti-infectious Agents from Lawsone in a Three-Component Reaction with Aldehydes and Isocyanides

“…The obtained single crystals, which appeared as purple platelets, were analyzed by X-ray diffraction (Figure 3). Mo-Kα radiation was used, and the compound showed a P2 In addition, the attribution of C4 and C9 of compound 9 was based on the previous study of Borgati et al, 40 where the authors performed a complete, comparative 1 H and 13 C signal assignment of p-naphthoquinones and ortho-and paranaphthofuroquinones. In their case, the presence of a proton at C3 allowed the differentiation/identification of C4 and C9 by HMBC correlation with a Δd between C4 and C9 as high as 8 ppm.…”

The evaluation of in vitro antichagasic and anti-SARS-CoV-2 potential of inclusion complexes of β- and methyl-β-cyclodextrin with naphthoquinone

“…In this context, naphthoquinones, belonging to the quinone class, have a characteristic naphthalene ring, which gives them redox properties that can interfere with oxidative processes in biological systems [ 3 , 4 ]. They have stood out due to biological properties such as anti-inflammatory [ 5 , 6 ], antineoplastic [ [7] , [8] , [9] ], antimicrobial [ 3 , 10 ], antifungal [ 11 , 12 ] , antiviral [ 13 ] and antiparasitic [ 4 , 10 , [14] , [15] , [16] ] ones.…”