Occurrence of Pesticides and PPCPs in Surface and Drinking Water in Southern Brazil: Data on 4-Year Monitoring

Caldas, Sergiane Souza; Arias, Jean Lucas O.; Rombaldi, Caroline; Mello, Lucas L.; Cerqueira, Maristela Barnes Rodrigues; Martins, Ayrton F.; Prímel, Ednei Gilberto

doi:10.21577/0103-5053.20180154

Cited by 43 publications

(30 citation statements)

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“…The azoles are used extensively because they are significantly less expensive than other antifungal treatments and their overall antimycotic activity is relatively broad spectrum [ 6 ]. Azole drugs are used in: (1) treatment and prophylaxis of livestock (e.g., ringworm in cattle, aspergillosis in poultry, oomycete infections in aquaculture [ 7 , 8 , 9 , 10 ], (2) treatment in veterinary medicine (e.g., pets and zoo animals) [ 11 , 12 ], (3) crop protection (e.g., mildews and rusts of grains, fruits, vegetables), (4) plant protection (e.g., leaf spot on flowers, scrubs and trees, including the timber industry) [ 4 ], (5) protection of buildings (e.g., antifouling coatings) [ 13 ], (f) cosmetic and hygiene products [ 14 ], and (6) prophylaxis and treatment in medicine [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Sterol 14α-Demethylase Ligand-Binding Pocket-Mediated Acquired and Intrinsic Azole Resistance in Fungal Pathogens

Rosam

Monk

Lackner

2020

JoF

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The fungal cytochrome P450 enzyme sterol 14α-demethylase (SDM) is a key enzyme in the ergosterol biosynthesis pathway. The binding of azoles to the active site of SDM results in a depletion of ergosterol, the accumulation of toxic intermediates and growth inhibition. The prevalence of azole-resistant strains and fungi is increasing in both agriculture and medicine. This can lead to major yield loss during food production and therapeutic failure in medical settings. Diverse mechanisms are responsible for azole resistance. They include amino acid (AA) substitutions in SDM and overexpression of SDM and/or efflux pumps. This review considers AA affecting the ligand-binding pocket of SDMs with a primary focus on substitutions that affect interactions between the active site and the substrate and inhibitory ligands. Some of these interactions are particularly important for the binding of short-tailed azoles (e.g., voriconazole). We highlight the occurrence throughout the fungal kingdom of some key AA substitutions. Elucidation of the role of these AAs and their substitutions may assist drug design in overcoming some common forms of innate and acquired azole resistance.

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Section: Introductionmentioning

confidence: 99%

Sterol 14α-Demethylase Ligand-Binding Pocket-Mediated Acquired and Intrinsic Azole Resistance in Fungal Pathogens

Rosam

Monk

Lackner

2020

JoF

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“…GCs have a tetra cyclic structure: three cyclohexane rings as well as cyclopentane rings [92,93]. Although natural and synthetic GCS have different cyclic networks, they have some common ring networks all around their physical properties (Table 1) [94].…”

Section: Properties Of Frequently Found Glucocorticoids In Watermentioning

confidence: 99%

An Overview of the Glucocorticoids’ Pathways in the Environment and Their Removal Using Conventional Wastewater Treatment Systems

et al. 2021

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Numerous micropollutants, especially endocrine-disrupting compounds (EDCs), can pollute natural aquatic environments causing great concern for human and ecosystem health. While most of the conversation revolves around estrogen and androgen, glucocorticoids (GCs) are also prevalent in natural waters. Despite the fact that GCs play a crucial role in both inflammatory and immunologic development activities, they are also detected in natural waters and considered as one of the EDCs. Although many researchers have mentioned the adverse effect of GCs on aquatic organisms, a complete management technology to remove these pollutants from surface and coastal waters is yet to be established. In the current study, six glucocorticoids (prednisone, prednisolone, cortisone, cortisol, dexamethasone, and 6R-methylprednisolone) have been selected according to their higher detection frequency in environmental waters. The concentration of selected GCs ranged from 0.05 ng/L to 433 ng/L and their removal efficiency ranged from 10% to 99% depending on the water source and associated removal technologies. Although advanced technologies are available for achieving successful removal of GCs, associated operational and economic considerations make implementation of these processes unsustainable. Further studies are necessary to resolve the entry routes of GCs compounds into the surface water or drinking water permanently as well as employ sustainable detection and removal technologies.

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“…This resource is nevertheless fragile, particularly impacted by increasing economic development (Peña-Guzmán et al 2019). Indeed, in many Latin America countries, there is a high population density in areas suffering from poor sanitary conditions, which contributes to the contamination/pollution of rivers and reservoirs that supply water (Caldas et al 2019;Peña-Guzmán et al 2019;Starling et al 2019). The chemical and physicochemical properties (e.g., water solubility, high adsorption capacity and low biodegradability) of many substances in daily use facilitate their flow without resistance reaching water sources, which can trigger problems not only for the environment but also for the health of living organisms (Janssens et al 1997;Knepper et al 1999;Kuster et al 2008;Hernández et al 2011a, b;Peña-Guzmán et al 2019).…”

Section: Presence Of Emerging Contaminants In the Aquatic Environment In Latin Americamentioning

confidence: 99%

Emerging Contaminants: Analysis, Aquatic Compartments and Water Pollution

Morin‐Crini¹,

Lichtfouse²,

Liu³

et al. 2021

Emerging Contaminants Vol. 1

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Over the past two decades, the presence of so-called emerging contaminants in various environmental compartments around the world, such as water, sediments, soils and atmosphere, and in a wide variety of consumer products has become a major concern for society, public health authorities, industry (namely food industry and water sector) and the agricultural sector. Some of these substances are endocrine disruptors and others are proven carcinogens and mutagens. In particular,

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Occurrence of Pesticides and PPCPs in Surface and Drinking Water in Southern Brazil: Data on 4-Year Monitoring

Cited by 43 publications

References 0 publications

Sterol 14α-Demethylase Ligand-Binding Pocket-Mediated Acquired and Intrinsic Azole Resistance in Fungal Pathogens

Sterol 14α-Demethylase Ligand-Binding Pocket-Mediated Acquired and Intrinsic Azole Resistance in Fungal Pathogens

An Overview of the Glucocorticoids’ Pathways in the Environment and Their Removal Using Conventional Wastewater Treatment Systems

Emerging Contaminants: Analysis, Aquatic Compartments and Water Pollution

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