Analysis of Isomeric Cannabinoid Standards and Cannabis Products by UPLC‑ESI‑TWIM-MS: a Comparison with GC‑MS and GC × GC-QMS

Santos, Nayara A. dos; Tose, Lílian V.; Silva, Samantha R. C. da; Murgu, Michael; Kuster, Ricardo Machado; Ortiz, Rafael S.; Camargo, Flávio Anastácio de Oliveira; Vaz, Boniek G.; Lacerda, Valdemar; Romão, Wanderson

doi:10.21577/0103-5053.20180152

Cited by 15 publications

(16 citation statements)

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“…Various HPLC and UPLC methods that have been reported for the analysis of cannabinoids in C. sativa L. plant samples and Cannabis consumer products, e.g. hashish, marijuana and cannabis oils, since the year 2010, are summarised in Tables and , and appraised in the following subsections.…”

Section: Hplc and Uplc (Or Uhplc) Analysis Of Naturally Occurring Canmentioning

confidence: 99%

“…Various LC‐based analytical techniques have become quite popular in the analysis of cannabinoids in Cannabis consumer products, which include smoking products, e.g. hashish and marijuana, cannabidiol oil, Cannabis olive oil, Cannabis tinctures, Cannabis medicinal products and Cannabis tea (Table ) . In the HPLC and UPLC (or UHPLC) methods, the use of PDA or MS detection technologies have become routine for the analysis of Cannabis consumer products.…”

Section: Hplc and Uplc (Or Uhplc) Analysis Of Naturally Occurring Canmentioning

confidence: 99%

“…The UPLC‐based methods for the analysis of cannabinoid consumers products published during the last decade have utilised both UV‐PDA and MS detectors . In those UPLC methods, an isocratic as well as a gradient elution with a mobile phase comprising acidified water–ACN or water–MeOH has been used routinely on UPLC columns, mainly of 100 mm length.…”

Section: Hplc and Uplc (Or Uhplc) Analysis Of Naturally Occurring Canmentioning

confidence: 99%

“…Most recently, Dos Santos et al . have reported an ESI‐quadrupole time‐of‐flight (QTOF) and ESI‐TWIM‐MS detection method for the UPLC analysis of cannabinoids using a Waters Acquity UPLC HSS T3 column (100 mm × 2.1 mm; particle size: 1.8 μm) and a multi‐step gradient mobile phase consisting of water–MeOH (containing 0.1% HCOOH) (Table ).…”

Section: Hplc and Uplc (Or Uhplc) Analysis Of Naturally Occurring Canmentioning

confidence: 99%

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A review on the recent advances in HPLC, UHPLC and UPLC analyses of naturally occurring cannabinoids (2010–2019)

Nahar

Önder

Sarker

2019

Phytochemical Analysis

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Introduction Organic molecules that bind to cannabinoid receptors are called cannabinoids, and they have similar pharmacological properties like the plant, Cannabis sativa L. Hyphenated liquid chromatography (LC), incorporating high‐performance liquid chromatography (HPLC) and ultra‐performance liquid chromatography (UPLC, also known as ultrahigh‐performance liquid chromatography, UHPLC), usually coupled to an ultraviolet (UV), UV‐photodiode array (PDA) or mass spectrometry (MS) detector, has become a popular analytical tool for the analysis of naturally occurring cannabinoids in various matrices. Objective To review literature on the use of various LC‐based analytical methods for the analysis of naturally occurring cannabinoids published since 2010. Methodology A comprehensive literature search was performed utilising several databases, like Web of Knowledge, PubMed and Google Scholar, and other relevant published materials including published books. The keywords used, in various combinations, with cannabinoids being present in all combinations, in the search were Cannabis, hemp, cannabinoids, Cannabis sativa, marijuana, analysis, HPLC, UHPLC, UPLC, quantitative, qualitative and quality control. Results Since 2010, several LC methods for the analysis of naturally occurring cannabinoids have been reported. While simple HPLC‐UV or HPLC‐UV‐PDA‐based methods were common in cannabinoids analysis, HPLC‐MS, HPLC‐MS/MS, UPLC (or UHPLC)‐UV‐PDA, UPLC (or UHPLC)‐MS and UPLC (or UHPLC)‐MS/MS, were also used frequently. Applications of mathematical and computational models for optimisation of different protocols were observed, and pre‐analyses included various environmentally friendly extraction protocols. Conclusions LC‐based analysis of naturally occurring cannabinoids has dominated the cannabinoids analysis during the last 10 years, and UPLC and UHPLC methods have been shown to be superior to conventional HPLC methods.

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Section: Hplc and Uplc (Or Uhplc) Analysis Of Naturally Occurring Canmentioning

confidence: 99%

Section: Hplc and Uplc (Or Uhplc) Analysis Of Naturally Occurring Canmentioning

confidence: 99%

Section: Hplc and Uplc (Or Uhplc) Analysis Of Naturally Occurring Canmentioning

confidence: 99%

Section: Hplc and Uplc (Or Uhplc) Analysis Of Naturally Occurring Canmentioning

confidence: 99%

See 2 more Smart Citations

A review on the recent advances in HPLC, UHPLC and UPLC analyses of naturally occurring cannabinoids (2010–2019)

Nahar

Önder

Sarker

2019

Phytochemical Analysis

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“…In order to address the quality control aspects of medicinal C. sativa, Calvi et al 17 (7), CBG (5), CBDA (4) and CBC (1). 19…”

Section: Gc Analysis Of Cannabinoids In Plant Samplesmentioning

confidence: 99%

Gas chromatographic analysis of naturally occurring cannabinoids: A review of literature published during the past decade

Nahar

Chen

Sarker

2019

Phytochemical Analysis

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Introduction Cannabinoids are organic compounds, natural or synthetic, that bind to the cannabinoid receptors and have similar pharmacological properties as produced by the cannabis plant, Cannabis sativa. Gas chromatography (GC), e.g. gas chromatography mass spectrometry (GC–MS), is a popular analytical tool that has been used extensively to analyse cannabinoids in various matrices. Objective To review published literature on the use of various GC‐based analytical methods for the analysis of naturally occurring cannabinoids published during the past decade. Methodology A comprehensive literature search was performed utilising several databases, like Web of Knowledge, PubMed and Google Scholar, and other relevant published materials including published books. The keywords used, in various combinations, with cannabinoids being present in all combinations, in the search were cannabinoids, Cannabis sativa, marijuana, analysis, GC, quantitative, qualitative and quality control. Results During the past decade, several GC‐based methods for the analysis of cannabinoids have been reported. While simple one‐dimensional (1D) GC–MS and GC‐FID (flame ionisation detector) methods were found to be quite common in cannabinoids analysis, two‐dimensional (2D) GC–MS as well as GC–MS/MS also were popular because of their ability to provide more useful data for identification and quantification of cannabinoids in various matrices. Some degree of automation in sample preparation, and applications of mathematical and computational models for optimisation of different protocols were observed, and pre‐analyses included various derivatisation techniques, and environmentally friendly extraction protocols. Conclusions GC‐based analysis of naturally occurring cannabinoids, especially using GC–MS, has dominated the cannabinoids analysis in the last decade; new derivatisation methods, new ionisation methods, and mathematical models for method optimisation have been introduced.

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Exploring the chemical profile of designer drugs by ESI(+) and PSI(+) mass spectrometry—An approach on the fragmentation mechanisms and chemometric analysis

et al. 2020

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The consumption of design drugs, frequently known as new psychoactive substances (NPS), has increased considerably worldwide, becoming a severe issue for the responsible governmental agencies. These illicit substances can be defined as synthetic compounds produced in clandestine laboratories in order to act as analogs of schedule drugs mimetizing its chemical structure and improving its pharmacological effects while hampering the control and making regulation more complicated. In this way, the development of new methodologies for chemical analysis of NPS drugs is indispensable to determine a novel class of drugs arising from the underground market. Therefore, this work shows the use of high-resolution mass spectrometry Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) applying different ionization sources such as paper spray ionization (PSI) and electrospray ionization (ESI) in the evaluation of miscellaneous of seized drugs samples as blotter paper (n = 79) and tablet (n = 100). Also, an elucidative analysis was performed by ESI(+) MS/MS experiments, and fragmentation mechanisms were proposed to confirm the chemical structure of compounds identified. Besides, the results of ESI(+) and PSI(+)-FT-ICR MS were compared with those of GC-MS, revealing that ESI(+)MS showed greater detection efficiency among the methodologies employed in this study. Moreover, this study stands out as a guide for the chemical analysis of NPS drugs, highlighting the differences between the techniques of ESI(+)-FT-ICR MS, PSI(+)-FT-ICR MS, and GC-MS.

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Analysis of Isomeric Cannabinoid Standards and Cannabis Products by UPLC‑ESI‑TWIM-MS: a Comparison with GC‑MS and GC × GC-QMS

Cited by 15 publications

References 44 publications

A review on the recent advances in HPLC, UHPLC and UPLC analyses of naturally occurring cannabinoids (2010–2019)

A review on the recent advances in HPLC, UHPLC and UPLC analyses of naturally occurring cannabinoids (2010–2019)

Gas chromatographic analysis of naturally occurring cannabinoids: A review of literature published during the past decade

Exploring the chemical profile of designer drugs by ESI(+) and PSI(+) mass spectrometry—An approach on the fragmentation mechanisms and chemometric analysis

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