Preparation of Magnetoliposomes with a Green, Low-Cost, Fast and Scalable Methodology and Activity Study against S. aureus and C. freundii Bacterial Strains

Silva, Rosangela Maria Ferreira da Costa e; Lara, Luciano Roni Silva; López, J. L.; Andrade, Ângela Leão; Oliveira, Junnia A. C.; Takahashi, Jacqueline A.; Vieira, Henriete S.; Matencio, Túlio; Stumpf, Humberto O.; Domingues, Rosana Zacarias

doi:10.21577/0103-5053.20180144

Cited by 21 publications

(1 citation statement)

References 53 publications

(80 reference statements)

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“…As shown in the overlap of the FTIR spectra of lecithin and the lecithin-coated SeNPs, all the characteristic bands of lecithin are still available in the lecithin-coated SeNPs spectrum: 1740 (ester carbonyl), 1630 (C=C), 1261, and 1044 cm −1 (P-O-R bonds). 60,61 Similarly, the most characteristic bands of β-CD are all shown in the spectrum of the β-CD-coated SeNPs: 2925 (C-H), 1151, and 1023 cm −1 (C-O-C). 62 The characteristic absorption peaks of PEG are also still present in the PEG-coated SeNPs spectrum: 2890 (C-H), 1200, and 1094 cm −1 (C-O-C).…”

Section: Characterization Of Coated Senps Using Different Coating Mat...mentioning

confidence: 95%

Evaluation of Different Surface Coating Agents for Selenium Nanoparticles: Enhanced Anti-Inflammatory Activity and Drug Loading Capacity

Mekkawy¹,

Fathy²,

Mohamed³

2022

DDDT

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Background: Inflammation is the keystone in the disease's pathological process in response to any damaging stimuli. Therefore, any agent that inhibits the inflammatory response is under focus, either a drug or a bioactive compound. Selenium nanoparticles have drawn attention in various biomedical applications, including the anti-inflammatory activity. Purpose: In the current study, we aimed to evaluate the capacity of different surface coating materials (soybean lecithin, PEG 6000, and β-cyclodextrin) to enhance the anti-inflammatory activity of the synthesized selenium nanoparticles (SeNPs). The capability of the coated SeNPs to adsorb indomethacin (IND) on their surfaces compared to the uncoated SeNPs was also evaluated. Methods: SeNPs were synthesized, coated with different materials, and characterized in vitro using X-ray diffraction, UV-Vis spectrophotometer, FTIR, SEM, TEM, and particle size and zeta potential measurements. The in vivo anti-inflammatory activity of the uncoated/coated SeNPs loaded into hydrogel was evaluated using a carrageenan-induced paw edema rat model. The effect of SeNPs surface coatings was further evaluated for IND loading capacity. Results: Our findings proved the superior anti-inflammatory activity of all coated SeNPs compared to the uncoated SeNPs, especially with β-cyclodextrin surface coating. Regarding the IND loading capacity of the prepared uncoated/coated SeNPs, the amount of drug loaded was 0.12, 1.12, 0.3, and 0.14 µg IND/µg SeNPs for the uncoated, lecithin-, PEG-and β-CD-coated SeNPs, respectively. Conclusion: Surface functionalization of SeNPs can provide a synergistic therapeutic activity. Our results are promising for further investigation of the in vivo anti-inflammatory synergistic activity of the IND-loaded surface-coated SeNPs.

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Section: Characterization Of Coated Senps Using Different Coating Mat...mentioning

confidence: 95%

Evaluation of Different Surface Coating Agents for Selenium Nanoparticles: Enhanced Anti-Inflammatory Activity and Drug Loading Capacity

Mekkawy¹,

Fathy²,

Mohamed³

2022

DDDT

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Dielectric and electromagnetic interference shielding properties of nano‐silicon carbide/montmorillonite and graphene nanoplatelets filled polyvinylidene fluoride/poly(3,4‐ethylenedioxythiophene)‐block‐poly(ethylene glycol) blend nanocomposites

Thanasekaran

Ahamed

Deshmukh

et al. 2022

J of Applied Polymer Sci

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Herein, hybrid polymer nanocomposite films comprising polyvinylidene fluoride (PVDF) and poly(3,4-ethylenedioxythiophene)-block-poly(ethylene glycol) (PEDOT-block-PEG) as matrices and silicon carbide nanoparticles (SiC NPs), montmorillonite (MMT) nanoclay, and graphene nanoplatelets (GNPs) as nanofillers were fabricated by solution casting. The structural, morphological, and thermal characteristics of the nanocomposite films were assessed using Fourier transform infrared spectroscopy (FTIR), x-ray diffraction (XRD), scanning electron microscope (SEM), thermogravimetric analyzer (TGA), and differential scanning calorimetry (DSC). The SEM results show the homogeneous distribution of nanofillers within the polymer matrix. The dielectric behavior and electromagnetic interference shielding efficiency (EMI SE) of the nanocomposites were also analyzed. The maximum dielectric constant (ε) and dielectric loss (tan δ) obtained are 47.77 and 12.08, respectively, at lower frequency (50 Hz, 150 C). The maximum EMI SE was observed to be 16.8 dB in the Ku-band region (12-18 GHz) for the nanocomposites with 20 wt% SiC, 8 wt% MMT, and 2 wt% GNPs loading. The EMI shielding was found to be absorption dominant and originated from the formation of a conductive network between hybrid nanofillers within the PVDF/PEDOT-block-PEG blend thereby improving the EMI SE values. These results suggest that PVDF/ PEDOT-block-PEG/SiC/MMT/GNPs nanocomposites can be used as an efficient EMI shielding material.

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Chromanone Lactones: A Neglected Group of Natural Products – Isolation, Structure Elucidation, Bioactivity, and Synthesis

Valdomir

Tietze

2022

Eur J Org Chem

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Chromanone lactones are a diverse family of fungal metabolites, which is biologically linked to tetrahydroxanthones. These compounds exhibit different structures that could be monomeric or dimeric, with different linkages and in combination with other monomers, but also fused to give more complex structures. They have been neglected so far, as they have not been recognized as an original group of natural products and as most of the publications related to these compounds have arisen only since the beginning of the century. In this Review, we discuss the isolation, the structural elucidation, the bioactivity and also the synthesis of chromanone lactones. Moreover, we present a classification of the different compounds of this family.

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Preparation of Magnetoliposomes with a Green, Low-Cost, Fast and Scalable Methodology and Activity Study against S. aureus and C. freundii Bacterial Strains

Cited by 21 publications

References 53 publications

Evaluation of Different Surface Coating Agents for Selenium Nanoparticles: Enhanced Anti-Inflammatory Activity and Drug Loading Capacity

Evaluation of Different Surface Coating Agents for Selenium Nanoparticles: Enhanced Anti-Inflammatory Activity and Drug Loading Capacity

Dielectric and electromagnetic interference shielding properties of nano‐silicon carbide/montmorillonite and graphene nanoplatelets filled polyvinylidene fluoride/poly(3,4‐ethylenedioxythiophene)‐block‐poly(ethylene glycol) blend nanocomposites

Chromanone Lactones: A Neglected Group of Natural Products – Isolation, Structure Elucidation, Bioactivity, and Synthesis

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