Chemo-Preventive Functions of Grape Seed Proanthocyanidin Extract against UV-Induced Intracellular Oxidative Stress and Tyrosinase Activity

Shi, Lei; Tang, Hua-Lin; Xu, Suling

doi:10.21577/0103-5053.20180098

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…Owing to the excellent antioxidant properties and remarkable free radical scavenging abilities of PAs, they plays a pharmacological role in combatting tumours, ageing and inflammation; immune regulation; prevention of cardiovascular diseases, Alzheimer's disease and Parkinson's disease; and improvement of visual function . Therefore, PAs have been widely used in functional food, medicine, health care products and cosmetics.…”

Section: Introductionmentioning

confidence: 99%

Rapid microwave‐assisted Porter method for determination of proanthocyanidins

Yin

Yang

Min

et al. 2019

Phytochemical Analysis

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Introduction Proanthocyanidins have been widely developed and utilised in food, medicine, health care products and cosmetics. Porter‐high‐performance liquid chromatography (HPLC) is a quantitative method often utilised in many fields. This method uses a water bath to reflux the proanthocyanidins, but the process is cumbersome, the reagent consumption is large, and multiple batches of simultaneous treatments cannot be evaluated. Objective To establish a more convenient, rapid and high‐batch processing method for determining the content of proanthocyanidins in functional food by HPLC. Methods N‐Butanol–hydrochloric acid and iron salt are used as the reaction medium in the Porter method. After investigating the optimal conditions, the hydrolysis of proanthocyanidins can be performed in a microwave reactor at a power of 640 W for 75 s in the Porter reaction system. The content of proanthocyanidins was determined by HPLC with external standards. Results After the rapid pretreatment of samples, proanthocyanidins were determined by HPLC with a diode array detector at a detection wavelength of 525 nm with 0.53 μg/mL and 1.61 μg/mL limits of detection and quantification, respectively, for proanthocyanidin ions, and the linearity was 0.9999. Intra‐ and inter‐day relative standard deviation values were between 1.5% and 3.1%, and the recovery was between 91.40% and 107.43% for the determination of different products, such as capsules, tablets and tea, which were similar to the values obtained with the conventional Porter method. Conclusion This method is a time‐saving and low cost approach for quantitative analysis of various proanthocyanidin health products that offers the advantages of high‐batch processing and environmental friendliness.

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Section: Introductionmentioning

confidence: 99%

Rapid microwave‐assisted Porter method for determination of proanthocyanidins

Yin

Yang

Min

et al. 2019

Phytochemical Analysis

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Potential of Herbal Extracts as Sunscreens and Antihyperpigmentation Treatment

Kothapalli

Bhosale

Thomas

et al. 2023

CDTH

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Background: Skin pigmentation is one of the most serious problems in the adult population of all races. The underlying factors of skin pigmentation are excessive exposure to UV radiation, oxidative stress, and other provocative causes that cause melasma, black spots, and post-inﬂammatory hyperpigmentation. Hence, treating hyperpigmentation disorders is challenging. Objective: Skin pigmentation occurs as a process of melanin biosynthesis triggered by UV exposure. Tyrosinase, an enzyme that catalyzes the rate-confining step in melanogenesis, if inhibited, can cause skin hypopigmentation. This has evoked an interest in reviewing plant extracts/ phytoconstituents, which can serve the purpose of sun protection and treat hyperpigmentation, ensuring skin glow for a better quality of life. Method: A literature search on Medline, PubMed, Embase, and Scopus databases was done using various keywords like hyperpigmentation, melasma, skin-lightening agents, and sunscreen. Result: Sun protection products for canopy with photo-aging and skin pigmentation are recommended. Tyrosinase inhibitors are first-line topical medicines available as single or combined topical formulations. Hydroquinone, retinoids, corticosteroids, and kojic acid are clinically proven as exceptionally powerful. However, the adverse effects reported with these small molecules largely impact skin appearance, dermatitis, and exogenous ochronosis. Currently, there is a rising trend towards comfortable, fascinating, and well-endured skin depigmenting agents from natural products that might be utilized by a wide populace. Conclusion: This present study aimed at exploring plant and fruit extracts together with their active ingredients as potential multitargeted anti-hyperpigmentation agents with sunscreen properties, tyrosinase inhibition, and skin whitening effects.

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Chemo-Preventive Functions of Grape Seed Proanthocyanidin Extract against UV-Induced Intracellular Oxidative Stress and Tyrosinase Activity

Cited by 2 publications

References 11 publications

Rapid microwave‐assisted Porter method for determination of proanthocyanidins

Rapid microwave‐assisted Porter method for determination of proanthocyanidins

Potential of Herbal Extracts as Sunscreens and Antihyperpigmentation Treatment

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