Antimicrobial Activity of Paepalanthus planifolius and its Major Components against Selected Human Pathogens

Amorim, Marcelo R. de; Hilário, Felipe; Sano, Paulo Takeo; Bauab, Taís Maria; Santos, Lourdes Campaner dos

doi:10.21577/0103-5053.20170199

Cited by 4 publications

(7 citation statements)

References 15 publications

(27 reference statements)

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“…The compounds 1-6 were dissolved in DMSO : H 2 O (2 : 8, v/v) to initial concentrations of 500 µg/mL. A 2-fold serial dilution was carried out in order to obtain concentration ranging from 1.95 to 250 µg/mL as described previously [28]. The positive controls ampicillin, amphotericin B, and fluconazole were purchased by Sigma-Aldrich while DMSO : H 2 O (2 : 8, v/v) was used as the negative control.…”

Section: Antimicrobial Assaymentioning

confidence: 99%

New Benzaldehyde and Benzopyran Compounds from the Endophytic Fungus Paraphaeosphaeria sp. F03 and Their Antimicrobial and Cytotoxic Activities

et al. 2019

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Three new benzaldehyde derivatives, sporulosaldeins A – C (1–3), and 3 new benzopyran derivatives, sporulosaldeins D – F (4–6), were discovered from an endophytic fungus, Paraphaeosphaeria sp. F03, which was isolated from Paepalanthus planifolius leaves. Compounds 1–6 were elucidated by 1- and 2-dimensional nuclear magnetic resonance experiments and high-resolution mass spectrometry analysis. The absolute configuration of compound 5 was determined through the comparison of experimental and calculated electronic circular dichroism data. Compounds 1–6 were found to exhibit antifungal activity with minimum inhibitory concentration (MIC) values of 7.8 – 250 µg/mL and racemic mixture of compound 6 exhibited weak cytotoxicity against MCF-7 and LM3 with IC50 values of 34.4 and 39.2 µM, respectively.

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Section: Antimicrobial Assaymentioning

confidence: 99%

New Benzaldehyde and Benzopyran Compounds from the Endophytic Fungus Paraphaeosphaeria sp. F03 and Their Antimicrobial and Cytotoxic Activities

et al. 2019

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“…After chromatographic profile by HPLC-PDA, a chosen fraction was submitted to separation in a semipreparative HPLC-PDA, leading to isolation of both 131 and 132 [ 65 ]. Compound 132 was also isolated from P. planifolius [ 75 ].…”

Section: Resultsmentioning

confidence: 99%

“…Results showed mutagenic activity in TA97a strain treated with naphthopyranone 132 [ 84 ]. Amorim et al (2018) also isolated 141 from P. planifolius [ 75 ].…”

Section: Resultsmentioning

confidence: 99%

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Review on Compounds Isolated from Eriocaulaceae Family and Evaluation of Biological Activities by Machine Learning

et al. 2022

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Eriocaulaceae is a pantropical family whose main center of biodiversity is in Brazil. In general, the family has about 1200 species, in which phytochemical and biological studies have shown a variety of structures and activities. The aim of this research is to compile the compounds isolated in the Eriocaulaceae family and carry out a computational study on their biological targets. The bibliographic research was carried out on six databases. Tables were built and organized according to the chemical class. In addition, a summary of the methods of isolating the compounds was also made. In the computational study were used ChEMBL platform, DRAGON 7.0, and the KNIME 4.4.0 software. Two hundred and twenty-two different compounds have been isolated in sixty-eight species, divided mainly into flavonoids and naphthopyranones, and minor compounds. The ligand-based virtual screening found promising molecules and molecules with multitarget potential, such as xanthones 194, 196, 200 and saponin 202, with xanthone 194 as the most promising. Several compounds with biological activities were isolated in the family, but the chemical profiles of many species are still unknown. The selected structures are a starting point for further studies to develop new antiparasitic and antiviral compounds based on natural products.

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“…The naphytopyranones have been shown to possess biological potential; these include planifolin and planifoliusin A. Planifolin is found to exhibit cytotoxic activity, while planifoliusin A is endowed with antimicrobial activity. 5,6 By virtue of the biological properties of the compounds present in this plant species, an endophytic fungus from Paepalanthus planifolius (host plant) was selected for chemical and biological studies. Microsphaeropsis arundinis is related to the class of Coelomycetes fungi.…”

Section: Introductionmentioning

confidence: 99%

Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis

Botero¹,

Amorim²,

Carlos³

et al. 2020

J. Braz. Chem. Soc.

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The endophytic fungus Microsphaeropsis arundinis was isolated from the capitula of the tropical plant Paepalanthus planifolius (Eriocaulaceae). The fungus was cultivated in seven different media, and the ethyl acetate extracts were tested against tumor cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT assay. The culture was scaled up using parboiled rice medium, and the crude extract was purified by classical chromatographic analyses, leading to the isolation of seven compounds. The seven compounds isolated from the culture media included a new aromatic polyketide (1) and other known metabolites. The structures of all the compounds were elucidated by 1D and 2D nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HRMS) analyses. An evaluation of the cytotoxicity of all the isolated compounds showed that these compounds exhibit less activity in comparison with the extract cultured in parboiled rice.

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Antimicrobial Activity of Paepalanthus planifolius and its Major Components against Selected Human Pathogens

Cited by 4 publications

References 15 publications

New Benzaldehyde and Benzopyran Compounds from the Endophytic Fungus Paraphaeosphaeria sp. F03 and Their Antimicrobial and Cytotoxic Activities

New Benzaldehyde and Benzopyran Compounds from the Endophytic Fungus Paraphaeosphaeria sp. F03 and Their Antimicrobial and Cytotoxic Activities

Review on Compounds Isolated from Eriocaulaceae Family and Evaluation of Biological Activities by Machine Learning

Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis

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