Chemical Constituents of Psychotria nemorosa Gardner and Antinociceptive Activity

Calixto, Nivea O.; Cordeiro, Millena Santos; Giorno, Thais Biondino Sardella; Oliveira, Gibson Gomes de; Lopes, Norberto P.; Fernandes, Patrícia Dias; Pinto, Ângelo C.; Rezende, Cláudia M.

doi:10.21577/0103-5053.20160219

Cited by 5 publications

(5 citation statements)

References 40 publications

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“…The same approach was applied to identify the other compounds found in tomato seed flour extracts. As a result, 2-hydroxyadipic acid [ 9 ], naringin [ 10 , 11 ], N -acetyl-tryptophan [ 12 , 13 , 14 ], quercetin-di- O -hexoside [ 15 , 16 ], kaempferol-di- O -hexoside [ 16 ], and azelaic acid [ 17 , 18 ] were tentatively identified.…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition of Tomato Seed Flours, and Their Radical Scavenging, Anti-Inflammatory and Gut Microbiota Modulating Properties

et al. 2021

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In the current study, the chemical composition and total phenolic content of tomato seed flours, along with potential health beneficial properties, including free radical scavenging capacities, anti-inflammatory capacities, and gut microbiota profile modulation, were examined using two different batches. Eight compounds were identified in the tomato seed flour, including malic acid, 2-hydroxyadipic acid, salicylic acid, naringin, N-acetyl-tryptophan, quercetin-di-O-hexoside, kaempferol-di-O-hexoside, and azelaic acid. The total phenolic contents of tomato seed flour were 1.97–2.00 mg gallic acid equivalents/g. Oxygen radical absorbing capacities (ORAC), 2,2-diphenyl-1-picrylhydrazyl radical scavenging capacities (DPPH), and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) cation radical scavenging capacities (ABTS) were 86.32–88.57, 3.57–3.81, and 3.39–3.58 µmoles Trolox equivalents/g, respectively, on a per flour dry weight basis. The mRNA expression of the pro-inflammatory markers, interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α), were dose-dependently suppressed by tomato seed flour extracts. The extracts altered five of the eight bacterial phyla and genera evaluated. The results may provide some scientific support for the use of tomato seed flour as value-added food ingredients.

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Section: Resultsmentioning

confidence: 99%

Chemical Composition of Tomato Seed Flours, and Their Radical Scavenging, Anti-Inflammatory and Gut Microbiota Modulating Properties

et al. 2021

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“…Regarding polyphenols, compound 2 was pyrogallol [15] and compound 15 was an ellagitannin which was identified as ellagic acid [9].…”

Section: Flavonoidsmentioning

confidence: 99%

Electrospray ionization-mass spectrometry of different extracts of the organs of Rumex cyprius and their antihepatotoxic effect

Eid¹,

Sokkar²

2022

Trop. J. Pharm Res

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Purpose: Phytochemical and biological investigations of the valuable plant, Rumex cyprius, family Polygonaceae, wildly grown in Saudi Arabia.Methods: Chloroform, ethyl acetate and methanol extracts were prepared from the different organs of R. cyprius. The extracts were analyzed by electrospray ionization source coupled to a mass spectrometer (ESI-MS) and tandem mass spectrometer (ESI-MS/MS) at different collision energies. The plant organs (leaf, fruit and stem) were standardized on the bases of quercetin by HPLC, and determined for their hepatoprotection in tetrachloride-induced acute liver toxicity using a mouse model.Results: Twenty-five phenolic compounds distributed between the leaf, fruit and stem of R. cyprius were identified. They were related to classes of anthraquinones, phenolic acids, flavonoid aglycones, glycosides and polyphenols. Twenty-two compounds in total were found and identified, and for the hepatoprotective effects, the leaf exhibited the best activity.Conclusion: R. cyprius is a source of potentially active phytoconstituents and a good naturalhepatoprotective drug. This study is being documented for the first time.

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“…Two 00 protoalkaloids 00 derived from the amino acid tyrosine were isolated from species of Palicourea: N-Methyltyramine was found in Palicourea marcgravii A. St.-Hil. (Kemmerling 1996) and hordenine in Psychotria nemorosa Gardner (Calixto et al 2017), for which no name is yet available in Palicourea. Furthermore, six hydroxycinnamic acid amides were detected by UPLC-MS in Palicourea sessilis (Vell.)…”

Section: Hymenocoleus Robbr and Puffia Razafim And B Bremermentioning

confidence: 99%

“…Tryptamine analogues-The group includes the structurally simplest alkaloids found in the genus Palicourea: N-formyltryptamine from Psychotria nemorosa (Calixto et al 2017) detail by Ribeiro et al (2016). However, the authors do not provide any data on optical rotation of their isolated compounds.…”

Section: Simple Indole Alkaloidsmentioning

confidence: 99%

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A revised classification of the sister tribes Palicoureeae and Psychotrieae (Rubiaceae) indicates genus-specific alkaloid accumulation

et al. 2021

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Tribes Palicoureeae and Psychotrieae (Rubiaceae, Gentianales) are complex and speciose sister groups with a pantropical distribution. Since the initial studies on ipecacuanha more than two centuries ago, species of the group have been subject to numerous phytochemical studies yielding diverse specialized ("secondary") metabolites, most of them alkaloids. However, the generic limits within the tribes have long been unclear and only recently, monophyletic genera have been delimited and segregated from a once broadly circumscribed Psychotria. Thus, a phylogeny-based and taxonomically updated review of phytochemical literature was performed which allowed assigning the bulk of phytochemical data previously reported for Psychotria to various segregate genera such as Carapichea, Eumachia and Palicourea. This review not only challenges the common perception of Psychotria as a monoterpene-indole alkaloid-rich genus. It also highlights that each of its relatives differs by accumulating specific groups of alkaloids, which is of major importance for understanding animal-plant interactions such as herbivory, as well as for drug discovery. The alkaloid complement of each of these genera is here enumerated and discussed, which should provide a framework for future studies addressing the biosynthesis, evolution, ecological and pharmacological significance of specialized metabolite differentiation in this abundant, ecologically and ethnopharmacologically important group.

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Chemical Constituents of Psychotria nemorosa Gardner and Antinociceptive Activity

Cited by 5 publications

References 40 publications

Chemical Composition of Tomato Seed Flours, and Their Radical Scavenging, Anti-Inflammatory and Gut Microbiota Modulating Properties

Chemical Composition of Tomato Seed Flours, and Their Radical Scavenging, Anti-Inflammatory and Gut Microbiota Modulating Properties

Electrospray ionization-mass spectrometry of different extracts of the organs of Rumex cyprius and their antihepatotoxic effect

A revised classification of the sister tribes Palicoureeae and Psychotrieae (Rubiaceae) indicates genus-specific alkaloid accumulation

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