Efavirenz Microcrystals for Dissolution Enhancement - Fluid-Bed Granulation, Scale-Up, Tableting and Pharmacokinetics
Livia Prado,
Isabella de Castro,
Karen Gonçalves
et al.
Abstract:Efavirenz, an antiretroviral drug, is a class 2 according to the biopharmaceutics classification system. Many dissolution enhancement systems have been tried and our group had success using wet milling to decrease particle size and granules were obtained by spray and freeze drying. In this paper we present data related to the upgrade in the process, raising the solids concentration in the suspension from 10 to 50% (m/v) and changing the drying step for a fluid bed granulation. After that, tablets were obtained… Show more
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