Evaluation of the Cytotoxicity and Genotoxicological Safety Profile of Bioactive Silver(i) Complexes With Aminoadamantane Ligands
Igor Henrique Cerqueira,
Maria Julia Mieli,
Anna Karla Pereira
et al.
Abstract:Silver(I) complexes of amantadine (atdH), memantine (mtnH) and rimantadine (rtdH), named Ag-atd, Ag-mtn and Ag-rtd, respectively, were recently synthesized and described in the literature as promising antibacterial agents. In the present study, the cytotoxicity of such complexes was evaluated against cultures of primary epidermal keratinocytes (HaCaT) and murine melanoma tumor cells (B16-F10), and mutagenicity was studied by the Ames test to investigate their abilities to induce gene mutations. The Ames test w… Show more
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