Agentes Antineoplásicos Biorredutíveis: Avanços E Desafios Após 20 Anos
Pedro Santana,
Gabriel Marques,
Mariana Cortezzi
et al.
Abstract:BIOREDUCTIVE ANTINEOPLASIC AGENTS: ADVANCES AND CHALLENGES AFTER 20 YEARS. Solid tumors are frequently affected by the presence of hypoxic cells, originating anomalous and disordered cell growth. This subpopulation presents resistance to conventional chemotherapy agents and radiotherapy, due to the difficulties of reaching the target region, the permanence in the G0 phase of cell cycle and the low local concentration of oxygen. The use of hypoxia activated prodrugs becomes, in this scenario, an effective and s… Show more
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