Applications of NMR and Theoretical Calculations to Study the O-H∙∙∙n Intramolecular Hydrogen Bond Effect on the Conformational Equilibrium of Cis-3-N-Ethylaminocyclohexanol and Cis-3-N,n-Diethylaminocyclohexanol
Abstract:Textbooks show that in cis-1,3-disubstituted cyclohexane molecule, the conformer with the substituents in the diaxial positions is higher in energy and hence, it presents a low population in the conformational equilibrium. The diaxial conformer is destabilized by the repulsion between the substituent groups and the axial hydrogen atoms on the same side of the ring. This interaction is known as the 1,3-diaxial interaction. In this study, the solvent effect on the conformational equilibria of cis-3-N-ethylaminoc… Show more
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