Abstract:THEORETICAL AND EXPERIMENTAL STUDY OF STRUCTURE AND REACTIVITY RELATED TO METABOLISM AND TOXICITY OF PARACETAMOL. An experimental and theoretical approach on oxidative metabolism of paracetamol was applied for the pharmaceutical chemistry learning. Classical reactions, functional group identification, structural parameter, and chemical reactivity using frontier orbitals and Fukui index were used explaining the main products between N-acetyl-p-benzosemiquinone (NAPQI) and thiolic compounds. The chemoprotection … Show more
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