SALICYLIC ACID INCORPORATION IN Fe3O4-BSA NANOPARTICLES FOR DRUG RELEASE

Abstract

The controlled release of Salicylic Acid (SA) influences the concentration and collateral effects of the drug. This release refers to the matrix in which the SA is incorporated. Among the matrices, Fe3O4 nanoparticles (NPs) stand out, for transporting drugs to specific sites. The functionalization of Fe3O4 by bovine serum albumin (BSA) can improve colloidal and chemical stability, in addition to increasing interactions with drugs. Thus, understanding the release kinetics of the AS incorporated in Fe3O4-BSA is essential to improve the controlled release. The study aimed the synthesis, characterization and release of the SA into the Fe3O4-BSA NPs. The results showed the functionalization of the Fe3O4-BSA NPs was effective and the average size was below 30 nm. The NPs showed colloidal stability above the pH of 7.5 which can be used as a drug carrier in blood plasma. Drug encapsulation into the NPs system was efficient (~91%) with about 30% of drug loading capability. The kinetic results showed the SA release mechanism was controlled by diffusion. The conclusion is that the incorporation of SA in Fe3O4-BSA NPs led to a release of SA in the first six hours, reaching equilibrium at 0.265 mg mL-1 and 1.83 mg.

The Effect of EDTA Functionalization on Fe3O4 Thermal Behavior

“…The surface functionalization of nanoparticles can introduce new functions to nanoparticles, as it can change the chemical and physical properties. In the case of Fe 3 O 4 nanoparticles, it appears that the functionalization can improve the colloidal stability 1,2,[17][18][19][20][21][22][23] , increase the chemical and thermal stability against the oxidation reaction 23 , but depending on the functionalizing agent it can decrease the magnetic property [24][25][26] The oxidation reaction of the Fe 3 O 4 nanoparticles is one of the factors that contributes to the decrease in the magnetic properties. In addition to these functions mentioned above, Marcos-Hernández et al 27 studied nano-Fe 3 O 4 electrodes with the aim of electrochemical reduction of nitrate.…”