CONSTITUENTS FROM ROOTS OF Maytenus distichophylla, ANTIMICROBIAL ACTIVITY AND TOXICITY FOR CELLS AND Caenorhabditis elegans

Morales, Shirley Alejandra Torres; Aguilar, Mariana Guerra de; Pereira, Rafael César Gonçalves; Duarte, Lucienir Pains; Sousa, Grasiely Faria de; Oliveira, Djalma Menezes de; Evangelista, Fernanda Cristina Gontijo; Sabino, Adriano de Paula; Viana, Roberta Oliveira; Alves, Viviane S.; Filho, Sidney Augusto Vieira

doi:10.21577/0100-4042.20170591

Cited by 4 publications

(3 citation statements)

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“…Contrary to our expectations [54], this extract displayed more cytotoxic effects towards S17 cell line than the tumorous THP-1 cell line (Selectivity Index = 0.844), having no anticancer activity for THP-1 cells. As a comparison, etoposide had a SI of 49.4 ± 1.20, which is according to reported data [55,56]. However, more research with other non-tumoral non-adherent cell lines is needed, as we only compared THP-1 cells to an adherent cell line (S17), and adherent and non-adherent cells are likely to have distinct responses.…”

Section: Anti-tumoral Activitysupporting

confidence: 64%

Microalgae as Potential Sources of Bioactive Compounds for Functional Foods and Pharmaceuticals

et al. 2022

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Microalgae are an untapped source of bioactive compounds with various biotechnological applications. Several species are industrially produced and commercialized for the feed or cosmetic industries, however, other applications in the functional food and pharmaceutical markets can be foreseen. In this study, nine industrial/commercial species were evaluated for in vitro antioxidant, calcium-chelating, anti-tumoral, and anti-inflammatory activities. The most promising extracts were fractionated yielding several promising fractions namely, of Tetraselmis striata CTP4 with anti-inflammatory activity (99.0 ± 0.8% reduction in TNF-α production in LPS stimulated human macrophages at 50 µg/mL), of Phaeodactylum Tricornutum with cytotoxicity towards cancerous cell lines (IC50 = 22.3 ± 1.8 μg/mL and 27.5 ± 1.6 μg/mL for THP-1 and HepG2, respectively) and of Porphyridium sp. and Skeletonema sp. with good chelating activity for iron, copper and calcium (IC50 = 0.047, 0.272, 0.0663 mg/mL and IC50 = 0.055, 0.240, 0.0850 mg/mL, respectively). These fractions were chemically characterized by GC–MS after derivatization and in all, fatty acids at various degrees of unsaturation were the most abundant compounds. Some of the species under study proved to be potentially valuable sources of antioxidant, metal chelators, anti-tumoral and anti-inflammatory compounds with possible application in the functional food and pharmaceutical industries.

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Section: Anti-tumoral Activitysupporting

confidence: 64%

Microalgae as Potential Sources of Bioactive Compounds for Functional Foods and Pharmaceuticals

et al. 2022

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“…For compound 5 , another study showed that this TP was five‐fold less cytotoxic against K562 cells when compared to the positive control, although no SI have been reported [35] . In our study, compound 7 exhibited moderate cytotoxicity for both cell lines, whereas this same compound showed two‐fold and three‐fold smaller IC 50 against K562 and THP‐1 cell lines, respectively, in another study [36] . A previous work reported that compound 8 was not cytotoxic against K562, [37] though our work reported a moderate cytotoxic activity against this same cell lines.…”

Section: Resultssupporting

confidence: 46%

Cytotoxic Activity of Triterpenoids from Cheiloclinium cognatum Branches against Chronic and Acute Leukemia Cell Lines

Pereira

Evangelista

Júnior

et al. 2020

Chemistry & Biodiversity

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Cheiloclinium cognatum (Miers) A.C.Sm. is an endemic species of Brazilian Cerrado that belongs to Celastraceae family. The phytochemical study of C. cognatum branches led to the identification of ten triterpenoids (TPs), 3β-acyloxyurs-12-ene (1), friedelin (2), β-friedelinol (3), glut-5-en-3β-ol (4), α-amyrin (5), βamyrin (6), β-sitosterol (7), canophyllol (8), 29-hydroxyfriedelan-3-one (9) and friedelane-3β,29-diol (10). TPs 4, 5 and 6 are described for the first Cheiloclinium genus and TPs 8 and 9 were isolated in expressive amounts. Their cytotoxic activities were evaluated against THP-1 and K562 leukemia cell lines. TPs 3 and 5 were the most active, exhibiting lower or similar IC 50 against both cell lines when compared to the controls. Their mechanisms of action were investigated suggesting an intrinsic mitochondrial pathway of apoptosis evidenced by up-regulation of BAK mRNA expression. Chemometric studies indicated that their activities may be related to their molecular size and shape as well as electronic interactions of C-3 hydroxy group with molecular targets.

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“…The following are available online, Table S1: Pentacyclic triterpenoids isolated from Celastraceae species (2001–2021) [ 257 , 258 , 259 , 260 , 261 , 262 , 263 , 264 , 265 , 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 277 , 278 , 279 , 280 , 281 , 282 , 283 , 284 , 285 , 286 , 287 , 288 , 289 , 290 , 291 , 292 , 293 , 294 , 295 , 296 , 297 , 298 , 299 , 300 , 301 , 302 , 303 , 304 , 305 , 306 , 307 ,…”

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Pentacyclic Triterpenoids Isolated from Celastraceae: A Focus in the 13C-NMR Data

et al. 2022

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The Celastraceae family comprises about 96 genera and more than 1.350 species, occurring mainly in tropical and subtropical regions of the world. The species of this family stand out as important plant sources of triterpenes, both in terms of abundance and structural diversity. Triterpenoids found in Celastraceae species display mainly lupane, ursane, oleanane, and friedelane skeletons, exhibiting a wide range of biological activities such as antiviral, antimicrobial, analgesic, anti-inflammatory, and cytotoxic against various tumor cell lines. This review aimed to document all triterpenes isolated from different botanical parts of species of the Celastraceae family covering 2001 to 2021. Furthermore, a compilation of their 13C-NMR data was carried out to help characterize compounds in future investigations. A total of 504 pentacyclic triterpenes were compiled and distinguished as 29 aromatic, 50 dimers, 103 friedelanes, 89 lupanes, 102 oleananes, 22 quinonemethides, 88 ursanes and 21 classified as others.

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CONSTITUENTS FROM ROOTS OF Maytenus distichophylla, ANTIMICROBIAL ACTIVITY AND TOXICITY FOR CELLS AND Caenorhabditis elegans

Cited by 4 publications

References 0 publications

Microalgae as Potential Sources of Bioactive Compounds for Functional Foods and Pharmaceuticals

Microalgae as Potential Sources of Bioactive Compounds for Functional Foods and Pharmaceuticals

Cytotoxic Activity of Triterpenoids from Cheiloclinium cognatum Branches against Chronic and Acute Leukemia Cell Lines

Pentacyclic Triterpenoids Isolated from Celastraceae: A Focus in the 13C-NMR Data

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