CHEMICAL VARIABILITY OF Allamanda cathartica L. FLOWERS ASSESSED BY MULTIVARIATE DATA ANALYSIS

Rodrigues, Deivisson W.; Muller, Ana Flavia Fischer; Bonomini, Tiago José; Klein‐Júnior, Luiz Carlos; Lucinda-Silva, Ruth Meri; Malheiros, Ângela

doi:10.21577/0100-4042.20170467

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…All data variables were scaled by the pareto method prior to PCA. PCA is an unsupervised method commonly used to identify patterns between multivariate samples [ 85 , 86 ] and was recently employed on the chemical variability of Allamanda cathartica extracts [ 87 ].…”

Section: Methodsmentioning

confidence: 99%

Phytochemical and Biological Study of Trophic Interaction between Pseudosphinx Tetrio L. Larvae and Allamanda Cathartica L.

Matignon¹,

Monpierre

et al. 2023

Plants

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In this article, we propose to explore the chemical interaction between Pseudosphinx tetrio L. and Allamanda cathartica L. using different analytical methods, including an innovative electrochemical approach (called electrochemical ecology) and multivariate analysis, and we investigate the potential antimicrobial effects (antibacterial and antifungal activities) of this interaction in order to gain a better understanding of their specific interaction. The analytical study presents a similar chemical profile between the leaves of healthy and herbivorous A. cathartica and the excretions of the caterpillars. The similar analytical profile of the leaves of A. cathartica and the excretions of P. tetrio, and the difference with the caterpillar bodies, suggests a selective excretion of compounds by the caterpillar. The measured antimicrobial activities support the physicochemical tests. The natural products found selectively in the excretions (rather than in the body) could explain the ability of P. tetrio to feed on this toxic Apocynaceae species.

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Section: Methodsmentioning

confidence: 99%

Phytochemical and Biological Study of Trophic Interaction between Pseudosphinx Tetrio L. Larvae and Allamanda Cathartica L.

Matignon¹,

Monpierre

et al. 2023

Plants

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“…All data variables were scaled by pareto method prior to PCA. ).PCA is an unsupervised method commonly used to identify patterns between multivariate samples (Wold et al 1987;Jolliffe, 2005) and was recently employed on chemical variability of Allamanda cathartica extracts (Rodrigues et al 2020).…”

Section: Cyclic Voltammetry (Cv)mentioning

confidence: 99%

Chemoecological Study of Trophic Interaction Between Pseudosphinx Tetrio L. Larvae and Allamanda Cathartica L.

Matignon¹,

Lo²,

Vicentini³

et al. 2021

Preprint

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The larval caterpillar Pseudosphinx tetrio L. is a species that feeds specifically on plants belonging to the family Apocynaceae. The genus Allamanda includes many shrubs or flowering trees which are grown throughout the tropical regions and are well known due their several biological properties. This work explores the interaction between the caterpillar and this plant using several analytical techniques such as thin layer chromatography, nuclear magnetic resonance spectroscopy, high performance liquid chromatography coupled with mass spectrometry and cyclic voltammetry. Further, a multivariate data analysis was performed in attempt to obtain better insights regard the samples. The results point out the similar profile between the health and herbivore Allamanda cathartica L.’s leaves and the caterpillars’ faeces. The similar analytical profile between the leaves of A. cathartica and the faeces of P. tetrio, as well as the difference with the caterpillar’s bodies suggest a selective excretion of compounds by the caterpillar. These compounds found selectively in the faeces (and not in the body) can explain that P. tetrio can feed this toxic Apocynaceae species.

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“…The entire plant is used to treat skin burns. It is effective against jaundice, malaria, and fungal infections, as well as having antithrombotic, immunomodulatory, cardiovascular, anti-ischemic, antiarrhythmic, antiangiogenic, antimutagenic, and gastroprotective properties (Prabhadevi et al, 2012;Rodrigues et al, 2020;Dokhe et al, 2023). Long-chain esters, triterpene esters, isoplumericin, plumericin, and plumeride are found in the roots.…”

Section: Introductionmentioning

confidence: 99%

Computational investigation of phytochemicals from Allamanda cathartica as a potent agonist of Peroxisome proliferator-activated receptor-gamma (PPARγ) for the treatment of Diabetes mellitus

Tomar,

Mishra,

Sahoo

et al. 2024

Preprint

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Diabetes, a chronic metabolic disease, has become a serious health problem worldwide. According to the latest data from the International Diabetes Federation (IDF), there were 451 million DM patients worldwide in 2017, and would be expected to increase to 693 million by 2045. Therefore, there is a need to develop new drug-like molecules to combat this problem. Peroxisome proliferators-activated receptors (PPARs) are ligand-inducible nuclear receptors that control many intracellular metabolic processes. PPARγ agonists can improve metabolism and reduce the side effects caused by single drugs and have become a valuable drug target for designing effective drugs for the treatment of type 2 diabetes. In the present investigation, by the application of bioactivity score prediction, molecular docking, and ADMET prediction approach, the potential and selective phytoconstituents with the highest binding affinity, and lower toxicity than reference drug rosiglitazone was gained from the curated datasets of Allamanda cathartica. Further molecular dynamics simulations were carried out to identify the favourable binding conformations when the top-scored phytoconstituents bind with the PPARγ receptors compared to the rosiglitazone. Compound AC2 interacts with the PPARγ proteins through the formation of 7 hydrogen bonds with the amino acid residues Phe282, His449, Tyr327, His323 and Ser289. The ligand was bound to the protein during the simulation since none of the complexes conformations were unstable and no unfolding or folding took place. Our results provided an approach to further design and optimize the natural product-inspired small druglike molecules as potential antidiabetic agents. The present study highlighted that the phytoconstituents of Allamanda cathartica has antidiabetic potential as PPARγ agonists that can be further explored for novel antidiabetic drug development.

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CHEMICAL VARIABILITY OF Allamanda cathartica L. FLOWERS ASSESSED BY MULTIVARIATE DATA ANALYSIS

Cited by 3 publications

References 9 publications

Phytochemical and Biological Study of Trophic Interaction between Pseudosphinx Tetrio L. Larvae and Allamanda Cathartica L.

Phytochemical and Biological Study of Trophic Interaction between Pseudosphinx Tetrio L. Larvae and Allamanda Cathartica L.

Chemoecological Study of Trophic Interaction Between Pseudosphinx Tetrio L. Larvae and Allamanda Cathartica L.

Computational investigation of phytochemicals from Allamanda cathartica as a potent agonist of Peroxisome proliferator-activated receptor-gamma (PPARγ) for the treatment of Diabetes mellitus

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