ISOLATION OF ANTIFUNGAL QUINOID DERIVATIVES FROM LEAVES OF Pentacalia desiderabilis (Vell.) Cuatre. (Asteraceae) USING IONIC LIQUID IN THE MICROWAVE ASSISTED EXTRACTION

Gomes, Kaio S.; Tamayose, Cinthia I.; Ferreira, Marcelo J. P.; Murakami, Cynthia; Young, Maria Cláudia M.; Antar, Guilherme Medeiros; Camilo, Fernanda F.; Sartorelli, Patrı́cia; Lago, João Henrique G.

doi:10.21577/0100-4042.20170319

Cited by 3 publications

(2 citation statements)

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“…Among Asteraceae species, the genus Senecio is represented by 20 jacaranone derivative-producing plant species [ 36 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ]. Besides the Bethencourtia [ 8 ], Packera [ 63 ], and Pentacalia [ 6 , 7 ] genera, each is represented by one species. All species belong to the Asteroideae (Tubuliflorae) subfamily of Asteraceae.…”

Section: Discussionmentioning

confidence: 99%

“…Since then, jacaranone derivatives ( n = 35) have been isolated from other plant species as well, most of them belonging to the family Asteraceae. Almost all of the isolated compounds have been studied for their biological activities (e.g., cytotoxic, antimicrobial, anti-inflammatory, antioxidant, sedative, antiprotozoal, and antifeedant effects), and many of them showed multiple activities [ 2 , 3 , 4 , 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Jacaranone Derivatives with Antiproliferative Activity from Crepis pulchra and Relevance of This Group of Plant Metabolites

Dávid

Kúsz

Pinke

et al. 2022

Plants

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Jacaranones are a small group of specific plant metabolites with promising biological activities. The occurrence of jacaranones is limited to only a few plant families, with Asteraceae being the most abundant source of these compounds. Therefore, jacaranones can also serve as chemotaxonomic markers. Our phytochemical investigation of Crepis pulchra L. (Asteraceae) resulted in three jacaranone derivatives (jacaranone, 2,3-dihydro-2-hydroxyjacaranone, 2,3-dihydro-2-methoxyjacaranone), and (6R,9S)-3-oxo-α-ionol-β-d-glucopyranoside, fulgidic acid, 12,15-octadecadienoic acid methyl ester, scopoletin and apigenin-7-O-β-d-glucoside. This is the first report on the isolation of jacaranones from a species belonging to the Cichorioideae subfamily of Asteraceae. Jacaranone derivatives were subjected to an in vitro antiproliferative assay against a panel of human cancer cell lines (MCF-7, MDA-MB-231, HeLa, and C33A), revealing high or moderate activities, with IC50 values ranging from 6.3 to 26.5 μM.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Jacaranone Derivatives with Antiproliferative Activity from Crepis pulchra and Relevance of This Group of Plant Metabolites

Dávid

Kúsz

Pinke

et al. 2022

Plants

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Gastroprotective Potential of the Hydroalcoholic Extract from Jacaranda puberula in Mice

Zanotelli

Locateli

Vecchia

et al. 2020

Rev. Bras. Farmacogn.

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Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts

Vujić

Vidaković

Jadranin

et al. 2020

Plants

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Helichrysum plicatum DC. is widely used in folk medicine in treating a variety of health disorders. The aim of this study was to examine the influence of different extraction solvents on the chemical composition, antioxidant potential, and antimicrobial activities of H. plicatum. Aerial parts were separately extracted with ethanol, dichloromethane, and sunflower oil. The oil extract (OE) was re-extracted with acetonitrile. A total of 142 compounds were tentatively identified in ethanolic (EE), dichloromethane (DCME), and acetonitrile (ACNE) extracts using HPLC-DAD/ESI-ToF-MS. The dominant compound class in all extracts were α-pyrones, alongside flavonoids in EE, terpenoids in DCME and ACNE, and phloroglucinols in DCME. The antioxidant potential of the extracts was assessed by the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) assay. EE and DCME possessed the most potent radical scavenging capacity. Antimicrobial activity was investigated on eight bacterial, two yeast, and one fungal species. All extracts exhibited high antifungal and notable antibacterial activities compared to control substances, with DCME being the most potent. DCME exhibited stronger antimicrobial activity against P. aeruginosa than the standard chloramphenicol.

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ISOLATION OF ANTIFUNGAL QUINOID DERIVATIVES FROM LEAVES OF Pentacalia desiderabilis (Vell.) Cuatre. (Asteraceae) USING IONIC LIQUID IN THE MICROWAVE ASSISTED EXTRACTION

Cited by 3 publications

References 0 publications

Jacaranone Derivatives with Antiproliferative Activity from Crepis pulchra and Relevance of This Group of Plant Metabolites

Jacaranone Derivatives with Antiproliferative Activity from Crepis pulchra and Relevance of This Group of Plant Metabolites

Gastroprotective Potential of the Hydroalcoholic Extract from Jacaranda puberula in Mice

Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts

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