Iontophoresis on minoxidil sulphate-loaded chitosan nanoparticles accelerates drug release, decreasing their targeting effect to hair follicles

Matos, Breno N.; Melo, Larissa Maria Araújo; Pereira, Maíra N.; Reis, Thaiene Avila; Cunha-Filho, Marcílio; Gratieri, Taís; Gelfuso, Guilherme M.

doi:10.21577/0100-4042.20160159

Cited by 5 publications

(4 citation statements)

References 22 publications

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“…Permeation studies using the modified Franz cell using porcine ear skin are well-known for comparing formulations [ 26 , 27 , 28 ]. However, this experiment could not distinguish the test formulation from the control since the crucial difference is the reduced runoff characteristic.…”

Section: Resultsmentioning

confidence: 99%

In Vitro Performance Analysis of a Minoxidil Thermosensitive Gel with Reduced Runoff for Eyebrow Hair Growth

Xavier

Matos

Barbalho

et al. 2023

Gels

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There is a growing interest in innovative products for eyebrow hair loss treatment with fewer adverse effects. Nevertheless, a fundamental formulation aspect of preventing the fragile skin from the ocular region from being irritated is that the formulations remain restricted to the application region and do not run off. Consequently, the methods and protocols in drug delivery scientific research must be adapted to fulfill such performance analysis demand. Thus, this work aimed to propose a novel protocol to evaluate the in vitro performance of a topical gel formulation with a reduced runoff for minoxidil (MXS) delivery to eyebrows. MXS was formulated with 16% poloxamer 407 (PLX) and 0.4% of hydroxypropyl methylcellulose (HPMC). The sol/gel transition temperature, viscosity at 25 °C, and formulation runoff distance on the skin were evaluated to characterize the formulation. The release profile and skin permeation were evaluated in Franz vertical diffusion cells for 12 h and compared to a control formulation (4% PLX and 0.7% HPMC). Then, the formulation’s performance at promoting minoxidil skin penetration with minimum runoff was evaluated in a vertical custom-made permeation template (divided into three areas: superior, middle, and inferior). The MXS release profile from the test formulation was comparable to that from the MXS solution and the control formulation. There was also no difference in the MXS amount that penetrated the skin in the permeation experiments in Franz diffusion cells using the different formulations (p > 0.05). However, the test formulation demonstrated a localized MXS delivery at the application site in the vertical permeation experiment. In conclusion, the proposed protocol could differentiate the test formulation from the control, attesting to its better performance in efficiently delivering MXS to the site of interest (middle third of application). The vertical protocol can be easily employed to evaluate other gels with a drip-free appeal.

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Section: Resultsmentioning

confidence: 99%

In Vitro Performance Analysis of a Minoxidil Thermosensitive Gel with Reduced Runoff for Eyebrow Hair Growth

Xavier

Matos

Barbalho

et al. 2023

Gels

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“…1) Magnetic stirrer was added to the receptor compartment and filled with phosphate buffer saline, pH 7.4 as the receptor medium. 16) Insulin loaded nanoparticles (containing 500 µg/mL insulin) were suspended in deionized water, and then added to the donor compartment (200 µL) for in vitro permeation test. One hundred microliter samples were taken from the receptor medium at different time intervals and replaced with the same volume.…”

Section: Methodsmentioning

confidence: 99%

<i>In Vitro</i> and <i>in Vivo</i> Comparative Study of Oral Nanoparticles and Gut Iontophoresis as Oral Delivery Systems for Insulin

ELKHATIB

Ali²,

Al-badrawy³

2021

Biological & Pharmaceutical Bulletin

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Multiple daily injections of insulin for diabetes cause many hazards for diabetic patients. Oral noninvasive insulin delivery could be more convenient and less painful than parenteral route. In past decades transdermal iontophoresis had been studied for insulin delivery across the skin with or without chemical permeation enhancers. However, the results of these studies were not efficacious and serum insulin levels were not therapeutically effective. In the present study an advanced technology "gut iontophoresis" for insulin delivery across the gut wall was compared with traditional oral insulin delivery in the form of nanoparticles. In vitro application of electric current to the intestinal membrane could enhance the flux of insulin nanoparticles (3.4 fold enhancement of insulin transport) from the donor to the receptor compartment in the Franz cell. In vivo iontophoresis of insulin nanoparticles through the gut wall would produce intense hypoglycemia (57% glycemia drop in 3 h) without damage of the intestinal tissues. Cell viability assay indicated that 50-500 µg/mL nanoparticles had no toxic effect on Caco-2 cells. Nanoparticles gut iontophoresis could be a promising non-invasive technique for oral insulin delivery.

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“…Chitosan along with hyaluronic acid and collagen is also used in hair setting lotions and gels to produce a coating which adds thickness, volume, strength and prevent hair damage. Furthermore, chitosan nanoparticles loaded with minoxidil is used for sustained release of minoxidil for effective transdermal transport and hair growth [ 80 ].…”

Section: Fungi and Associated Use In Cosmetic Productmentioning

confidence: 99%

Eminence of Microbial Products in Cosmetic Industry

Gupta

Rajput

Oza

et al. 2019

Nat. Prod. Bioprospect.

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Cosmetology is the developing branch of science, having direct impact on the society. The cosmetic sector is interested in finding novel biological alternatives which can enhance the product attributes as well as it can substitute chemical compounds. Many of the compounds are having biological origin and are acquire from bacteria, fungi, and algae. A range of biological compounds, like bio-surfactant, vitamins, antioxidants, pigments, enzymes, peptides have promising features and beneficial properties. Moreover, these products can be produced commercially with ease. The review will encompass the importance and use of microbial compounds for new cosmetic formulations as well as products associated with it.

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Iontophoresis on minoxidil sulphate-loaded chitosan nanoparticles accelerates drug release, decreasing their targeting effect to hair follicles

Cited by 5 publications

References 22 publications

In Vitro Performance Analysis of a Minoxidil Thermosensitive Gel with Reduced Runoff for Eyebrow Hair Growth

In Vitro Performance Analysis of a Minoxidil Thermosensitive Gel with Reduced Runoff for Eyebrow Hair Growth

<i>In Vitro</i> and <i>in Vivo</i> Comparative Study of Oral Nanoparticles and Gut Iontophoresis as Oral Delivery Systems for Insulin

Eminence of Microbial Products in Cosmetic Industry

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