Aplicação de amidoximas como catalisadores da reação de alilação por aliltrifluoroborato de potássio em meio bifásico

Synthesis and antifungal activity of new O-alkylamidoximes

“…In all cases, the corresponding amidoximes 2a-h were obtained in short reaction times and moderate to high yields after purification by crystallization (Figure 1). The characterization data of the obtained compounds are in accordance with the literature (Li et al 2013;Ozcan et al 2013;Andrade et al 2016;Tarasenko et al 2017). Thus, compound 2a was prepared at the shortest reaction time probably due to its high solubility in the reaction medium and lower steric hindrance.…”

“…(Z)-N'-hydroxy-4-methylbenzimidamide (3d): white solid: mp 144-146 ºC; IR (KBr pellet): max 747, 823,936,1099,1391,1418,1588,1664,2916,3049,3367, 3500 cm -1 ; 1 H NMR (400 MHz, DMSO-d6) δ 2.31 (3H, s, CH3aryl), 5.73 (2H, s, NH2), 7.17 (2H, d, J = 8.2 Hz, HAryl), 7.56 (2H, d, J = 8.2 Hz, HAryl), 9.52 (1H, s, OH); 13 C NMR (100 MHz, DMSO-d6) δ 20. 8, 125.3, 128.6, 130.5, 138.2, 150.8, Compound data are in accordance with the literature (Andrade et al 2016;Tarasenko et al 2017).…”

“…1, 122,6, 125.9, 129.7, 129.5, 133.3, 137.1, 150.9. Compound data are in accordance with the literature (Andrade et al 2016).…”

“…4, 128.1, 128.9, 133.4, 150.8. Compound data are in accordance with the literature (Ozcan et al 2013;Andrade et al 2016).…”

“…The general strategy for the synthesis of the new antifungal agents involved two reaction steps, the preparation of the amidoximes 2 from different nitriles followed by the alkylation of the obtained compounds to afford the O-alkylamidoximes. The synthesis started from the reaction of commercially available nitriles 1a-h and hydroxylamine hydrochloride under sonication (Barros et al 2011;Andrade et al 2016). In all cases, the corresponding amidoximes 2a-h were obtained in short reaction times and moderate to high yields after purification by crystallization (Figure 1).…”