Evaluation of Plasma Asprosin Concentration in Patients with Coronary Artery Disease

Abstract

Introduction The goal of this study is to investigate the association between diagnosis and severity of coronary artery disease (CAD) and Asprosin level. Methods Patients diagnosed with CAD who underwent conventional coronary angiography for the first time were included in the present study. The patients were divided into four groups, each consisting of 20 individuals, as medical group, single coronary lesion group, double coronary lesion group, and multiple coronary lesions group. Serum Asprosin values and Gensini scores of the groups were compared in terms of compliance. Results In this study, Asprosin values were found to be significantly higher in the multiple coronary lesions group than in the medical, single coronary, and double coronary lesion groups ( P <0.05). In the double coronary lesion group, Asprosin values were significantly higher ( P <0.05) than the in the medical and single coronary lesion groups. It was also found that Asprosin values did not differ at significant levels in the medical and single coronary lesion groups ( P >0.05). It was determined that the increases in Asprosin values and Gensini scores were compatible with each other. Conclusion The present study showed that the increases in serum Asprosin levels, along with the increases in the number of coronary arteries with critical stenosis, might be a marker in diagnosing and determining the severity of CAD.

Serum asprosin levels are increased in patients with periodontitis and ST‐segment elevation myocardial infarction and correlated with periodontal parameters: A case–control study

“…reported that asprosin levels could be a reliable marker for unstable angina pectoris, which can predict the severity of ACS, and changes in asprosin levels are positively correlated with the Syntax score 25 . In a study by Güven et al., they found that asprosin values in the double coronary lesion group were significantly higher than in the medical and single coronary lesion groups 26 . In another study, serum asprosin levels were higher in patients with coronary artery disease than in subjects without coronary artery disease 14 .…”

“…25 In a study by Güven et al, they found that asprosin values in the double coronary lesion group were significantly higher than in the medical and single coronary lesion groups. 26 In another study, serum asprosin levels were higher in patients with coronary artery disease than in subjects without coronary artery disease. 14 Algin et al found that plasma asprosin values were higher in patients with one-month mortality compared to the study group and lower in the control group.…”

Serum Asprosin Level as a New Biomarker in Differentiating Familial Mediterranean Fever Attacks

“…According to our study results, aiming to increase the level of asprosin may reduce the number and severity of attacks. Asprosin has also been demonstrated in some studies to contribute to wound healing, have protective effects on the myocardium, ameliorate endothelial damage, and significantly improve left ventricular functions [ 21 , 22 ].…”

Circulating Asprosin Concentrations in Patients with Obesity and Carbohydrate Disturbances

“…A study showed by comparing the levels of asprosin and scoring system that changes in the levels of asprosin were positively correlated with the Syntax score [28]. Another two cross-section analyzes found higher asprosin values in patients with CAD in comparison to those without vessel patho logy [29,30]. In our study, for the first time was reported for a positive relationship between serum asprosin levels and intima media thickness of the common carotid artery-non-invasive marker of early arterial wall alteration.…”