Combined Heart and Kidney Transplantation: Initial Clinical Experience

Atik, Fernando Antibas; Borges, Carolina de Castro; Ulhoa, Marcelo Botelho; Chaves, Renato Bueno; Barzilai, Vitor Salvatore; Biondi, Rodrigo Santos; Almeida, Tiago Martins de; Medeiros, Isabela Novais; Cardoso, Helen Souto Siqueira

doi:10.21470/1678-9741-2020-0720

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…It is known that the heart and kidney have different acceptable cold ischemic times without damage, but the increased time can lead to acute rejection, graft loss, and delayed graft function [37][38][39][40][41]. To avoid this complication, the included studies adopted different strategies to reach the lowest overall ischemic time possible, for example, donors were transferred to the same hospital as recipients to reduce heart ischemic time [16,24]. However, these single-center studies did not assess the significance of the association between cold or warm ischemic time and sHKTx outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 781 articles were identified based on the literature search criteria and 15 eligible papers were included in qualitative synthesis and meta-analysis [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24], including 376 patients who underwent the procedure from 1996 to 2019. All articles were single-center retrospective studies from 15 different transplantation centers in Austria, Belgium, the United States of America, the United Kingdom, Germany, Taiwan, Italy, New Zealand, Argentina, Spain, France, and Brazil.…”

Section: Characteristics Of the Selected Literaturementioning

confidence: 99%

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Simultaneous Heart and Kidney Transplantation: A Systematic Review and Proportional Meta-Analysis of Its Characteristics and Long-Term Variables

Sampaio,

Faleiro,

Vieira

et al. 2024

Transpl Int

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Patients with end-stage heart disease who undergo a heart transplant frequently have simultaneous kidney insufficiency, therefore simultaneous heart and kidney transplantation is an option and it is necessary to understand its characteristics and long-term variables. The recipient characteristics and operative and long-term variables were assessed in a meta-analysis. A total of 781 studies were screened, and 33 were thoroughly reviewed. 15 retrospective cohort studies and 376 patients were included. The recipient’s mean age was 51.1 years (95% CI 48.52–53.67) and 84% (95% CI 80–87) were male. 71% (95% CI 59–83) of the recipients were dialysis dependent. The most common indication was ischemic cardiomyopathy [47% (95% CI 41–53)] and cardiorenal syndrome [22% (95% CI 9–35)]. Also, 33% (95% CI 20–46) of the patients presented with delayed graft function. During the mean follow-up period of 67.49 months (95% CI 45.64–89.33), simultaneous rejection episodes of both organ allografts were described in 5 cases only. Overall survival was 95% (95% CI 88–100) at 30 days, 81% (95% CI 76–86) at 1 year, 79% (95% CI 71–87) at 3, and 71% (95% CI 59–83) at 5 years. Simultaneous heart and kidney transplantation is an important option for concurrent cardiac and renal dysfunction and has acceptable rejection and survival rates.

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Section: Discussionmentioning

confidence: 99%

Section: Characteristics Of the Selected Literaturementioning

confidence: 99%

Simultaneous Heart and Kidney Transplantation: A Systematic Review and Proportional Meta-Analysis of Its Characteristics and Long-Term Variables

Sampaio,

Faleiro,

Vieira

et al. 2024

Transpl Int

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“…Кількість пацієнтів, які потребують трансплантації комплексу «серце -нирка» щорічно продовжує зростати. За час перебування на листку очікування протягом перших трьох місяців смертність настає у 21% пацієнтів із хронічна хвороба нирок (ХХН), які потребували гемодіалізу та у 7% пацієнтів, з ХХН, які не потребували гемодіалізу [1,2,3].…”

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Simultaneous heart and kidney transplantation: Our first experience

Тодуров

Kovtun

Chaikovska

et al. 2023

Ukr. J. Nephrol. and Dial.

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The gold standard treatment for end-stage heart and kidney failure is simultaneous heart and kidney transplantation. The global number of recipients on the waiting list and performed organ transplants increases annually. However, there is a lack of well-defined selection criteria for multi-organ transplants, leading to variations based on geographic region and local protocols. In this study, we present our initial experience with simultaneous heart and kidney transplantation in Patient P, a 51-year-old individual with severe calcification of the mitral valve and end-stage chronic kidney disease. Surgical correction was not possible, and thus the patient underwent orthotopic simultaneous heart and kidney transplantation. During the early postoperative period, the patient experienced acute renal failure in the transplanted kidney, which was managed through courses of hemodialysis. The findings of this clinical observation represent the first experience of multi-organ transplantation in Ukraine. Our clinical observation illustrates the successful feasibility of simultaneous orthotopic heart and kidney transplantation, showcasing promising immediate and medium-term follow-up results.

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Combined Heart and Kidney Transplantation: Initial Clinical Experience

Cited by 2 publications

References 13 publications

Simultaneous Heart and Kidney Transplantation: A Systematic Review and Proportional Meta-Analysis of Its Characteristics and Long-Term Variables

Simultaneous Heart and Kidney Transplantation: A Systematic Review and Proportional Meta-Analysis of Its Characteristics and Long-Term Variables

Simultaneous heart and kidney transplantation: Our first experience

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