Indigo Carmine Hemodynamic Studies to Treat Vasoplegia Induced by Compound 48/80 in a Swine Model of Anaphylaxis

Effect of Nitric Oxide Pathway Inhibition on the Evolution of Anaphylactic Shock in Animal Models: A Systematic Review

“…The use of IC before shock induction was shown to cause pronounced hypotension [26] and a worse survival rate compared with controls [25].…”

“…Nine hundred ninety unique studies were found in the literature search and screened for eligibility based on title/abstract screening against the pre-set inclusion and exclusion criteria. Of the 135 studies identified as eligible for full-text screening, 17 studies were finally selected for inclusion in the review [10,14,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]. A detailed PRISMA flow diagram regarding the screening and selection process is available in Figure 3.…”

“…First, we grouped the studies based on their status as pre-treatment or post-treatment studies. Five studies had experimental models for both [25][26][27][28]35]. We next organized the studies according to animal species.…”

“…We next organized the studies according to animal species. Two studies used dogs [29,30], five used rats [14,25,[31][32][33], five used mice [10,23,24,34,37], three used pigs [26,28,35] and two studies used rabbits [27,36]. The characteristics are summarized in Tables 1 and 2.…”

“…Note that some studies had experimental groups for more than one medication. Twelve studies used NG-nitro-L-arginine methyl ester (L-NAME) [10,14,[23][24][25][29][30][31][32]34,36,37], seven studies used methylene blue (MB) [10,23,25,27,28,33,35], two studies used indigo carmine (IC) [25,26], one study used Aminoguanidine (AG) [32], one used 7-Nitroindazole (7-NI) [32] and two used 1H- [1,2,4] Oxadiazole [4,3-a] quinoxalin-1-one (ODQ) [10,23].…”