Saphenous Vein Vasa Vasorum as a Potential Target for Perivascular Fat-Derived Factors

Loesch, Andrzej; Dashwood, Michael R.

doi:10.21470/1678-9741-2020-0031

Cited by 3 publications

(3 citation statements)

References 45 publications

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“…The no-touch technique includes a pedicle of stromal tissue, adventitia, vasa vasorum, and perivascular adipose tissue. This local tissue niche in close proximity to the vasa vasorum is a source of contractile and relaxant factors with potential to influence vasa vasorum function and contribute to vein graft patency ( 137 ). A recent multicenter randomized controlled trial comparing outcomes in no-touch versus conventional saphenous vein graft harvest revealed no differences between harvest techniques in total graft occlusion, stenosis, or cardiovascular death, although inclusion in a meta-analysis uncovered a reduction in graft occlusion associated with no-touch harvest ( 138 ).…”

Section: Introductionmentioning

confidence: 99%

On vasa vasorum: A history of advances in understanding the vessels of vessels

Phillippi

2022

Sci. Adv.

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The vasa vasorum are a vital microvascular network supporting the outer wall of larger blood vessels. Although these dynamic microvessels have been studied for centuries, the importance and impact of their functions in vascular health and disease are not yet fully realized. There is now rich knowledge regarding what local progenitor cell populations comprise and cohabitate with the vasa vasorum and how they might contribute to physiological and pathological changes in the network or its expansion via angiogenesis or vasculogenesis. Evidence of whether vasa vasorum remodeling incites or governs disease progression or is a consequence of cardiovascular pathologies remains limited. Recent advances in vasa vasorum imaging for understanding cardiovascular disease severity and pathophysiology open the door for theranostic opportunities. Approaches that strive to control angiogenesis and vasculogenesis potentiate mitigation of vasa vasorum–mediated contributions to cardiovascular diseases and emerging diseases involving the microcirculation.

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Section: Introductionmentioning

confidence: 99%

On vasa vasorum: A history of advances in understanding the vessels of vessels

Phillippi

2022

Sci. Adv.

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“…Recently, eNOS expression has been found in the adipocytes of various adipose tissues, contributing to the production of vascular NO and modulating vascular (patho)physiology. 15 , 16 Among different adipose tissues, perivascular adipose tissue (PVAT) plays a crucial role in obesity-induced vascular dysfunction. 17 , 18 In healthy conditions, PVAT has anti-contractile properties and modulates the normal function of the vasculature.…”

Section: Introductionmentioning

confidence: 99%

Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodelling via chemerin

Man,

Zhou,

Reifenberg

et al. 2023

Cardiovascular Research

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Aims Obesity is an epidemic that is a critical contributor to hypertension and other cardiovascular diseases. Current paradigms suggest that endothelial nitric oxide synthase (eNOS/NOS3) in the vessel wall is the primary regulator of vascular function and blood pressure. However, recent studies have revealed the presence of eNOS/NOS3 in the adipocytes of white adipose tissues and perivascular adipose tissues (PVATs). The current understanding of the role of adipocyte NOS3 is based mainly on studies using global knockout models. The present study aimed to elucidate the functional significance of adipocyte NOS3 for vascular function and blood pressure control. Methods and Results We generated an adipocyte-specific NOS3 knockout mouse line using adiponectin promotor-specific Cre-induced gene inactivation. Control and adipocyte-specific NOS3 knockout (A-NOS3 KO) mice were fed a high-fat diet (HFD). Despite less weight gain, A-NOS3 KO mice exhibited a significant increase in blood pressure after HFD feeding, associated with exacerbated vascular dysfunction and remodeling. A-NOS3 KO mice also showed increased expression of signature markers of inflammation and hypoxia in the PVATs. Among the differentially expressed adipokines, we have observed an upregulation of a novel adipokine, chemerin, in A-NOS3 KO mice. Chemerin was recently reported to link obesity and vascular dysfunction. Treatment with chemerin neutralizing antibody normalized the expression of remodeling markers in the aorta segments cultured in serum from HFD-fed A-NOS3 KO mice ex vivo. Conclusions These data suggest that NOS3 in adipocytes is vital in maintaining vascular homeostasis; dysfunction of adipocyte NOS3 contributes to obesity-induced vascular remodeling and hypertension.

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“…To date, numerous studies using global eNOS-deficient mice have demonstrated the antihypertensive, antithrombotic, and anti-atherosclerotic effects of eNOS, which were mainly attributed to NO derived from the endothelium. Indeed, eNOS expression has been identified in both endothelial cells and adipocytes in PVAT and both contribute to the production of vascular NO and modulate vascular pathophysiology [ 5 , 6 ]. Although there are reviews discussing several aspects of PVAT, the functions of eNOS in PVAT have not been fully described.…”

Section: Introductionmentioning

confidence: 99%

Endothelial Nitric Oxide Synthase in the Perivascular Adipose Tissue

et al. 2022

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Perivascular adipose tissue (PVAT) is a special type of ectopic fat depot that adheres to most vasculatures. PVAT has been shown to exert anticontractile effects on the blood vessels and confers protective effects against metabolic and cardiovascular diseases. PVAT plays a critical role in vascular homeostasis via secreting adipokine, hormones, and growth factors. Endothelial nitric oxide synthase (eNOS; also known as NOS3 or NOSIII) is well-known for its role in the generation of vasoprotective nitric oxide (NO). eNOS is primarily expressed, but not exclusively, in endothelial cells, while recent studies have identified its expression in both adipocytes and endothelial cells of PVAT. PVAT eNOS is an important player in the protective role of PVAT. Different studies have demonstrated that, under obesity-linked metabolic diseases, PVAT eNOS may be even more important than endothelium eNOS in obesity-induced vascular dysfunction, which may be attributed to certain PVAT eNOS-specific functions. In this review, we summarized the current understanding of eNOS expression in PVAT, its function under both physiological and pathological conditions and listed out a few pharmacological interventions of interest that target eNOS in PVAT.

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Saphenous Vein Vasa Vasorum as a Potential Target for Perivascular Fat-Derived Factors

Cited by 3 publications

References 45 publications

On vasa vasorum: A history of advances in understanding the vessels of vessels

On vasa vasorum: A history of advances in understanding the vessels of vessels

Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodelling via chemerin

Endothelial Nitric Oxide Synthase in the Perivascular Adipose Tissue

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