Are Pre and Postoperative Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio Associated with Early Postoperative AKI Following CABG?

Engin, Mesut

doi:10.21470/1678-9741-2019-0482

Cited by 12 publications

(7 citation statements)

References 5 publications

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“…Recently, some markers composed of the ratios of white blood cell (WBC) subgroups have been newly introduced and demonstrated to be associated with the risks and outcomes of cardiovascular diseases and related surgeries. For example, for cardiac surgery patients, the value of the neutrophil-to-lymphocyte ratio (NLR) can serve as a predictor of early and late mortality ( 4 , 5 ), postoperative acute kidney injury ( 6 ), and postoperative atrial fibrillation ( 7 , 8 ), while the platelet-to-lymphocyte ratio (PLR) has been reported to be a predictor of prognosis in patients with aortic dissection ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Preoperative Lymphocyte-to-Monocyte Ratio as a Prognostic Predictor of Long-Term Mortality in Cardiac Surgery Patients: A Propensity Score Matching Analysis

Zhou

Liang

et al. 2021

Front. Cardiovasc. Med.

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Aims: To evaluate the prognostic value of the preoperative lymphocyte-to-monocyte ratio (LMR) in patients who underwent cardiac surgery.Methods: Clinical data were extracted from the Medical Information Mart for Intensive Care III (MIMIC-III) database. The optimal cutoff value of LMR was determined by X-tile software. The Cox proportional hazard model was applied for the identification of independent prognostic factors of 4-year mortality and survival curves were estimated using the Kaplan-Meier method. In order to balance the influence of potential confounding factors, a 1:1 propensity score matching (PSM) method was performed.Results: A total of 1,701 patients were included. The X-tile software indicated that the optimal cutoff value of the LMR for 4-year mortality was 3.58. After PSM, 489 pairs of score-matched patients were generated. The Cox proportional hazard model showed that patients with an LMR < 3.58 had a significantly higher 4-year mortality than patients with an LMR ≥ 3.58 in the entire cohort (HR = 1.925, 95%CI: 1.509–2.456, p < 0.001) and the PSM subset (HR = 1.568, 95%CI: 1.2–2.05, p = 0.001). The survival curves showed that patients with an LMR < 3.58 had a significant lower 4-year survival rate in the entire cohort (71.7 vs. 88.5%, p < 0.001) and the PSM subset (73.2 vs. 81.4%, p = 0.002).Conclusions: A lower LMR (<3.58) was associated with a higher risk of 4-year mortality and can serve as a prognostic predictor of the long-term mortality in cardiac surgery patients.

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Section: Introductionmentioning

confidence: 99%

Preoperative Lymphocyte-to-Monocyte Ratio as a Prognostic Predictor of Long-Term Mortality in Cardiac Surgery Patients: A Propensity Score Matching Analysis

Zhou

Liang

et al. 2021

Front. Cardiovasc. Med.

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“…Indeed, there are no reports concerning the impact of PLR on long-term mortality after bypass surgery. Studies evaluating the usefulness of PLR in CABG patients reported its highest importance for prediction of acute kidney injury (AKI) [ 94 ] and post-operative atrial fibrillation [ 95 ]. Both complications are obviously associated with inflammatory response and domination of neutrophils engagement; therefore, NLR was also pointed out [ 96 ], as mentioned before.…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Significance of Neutrophil to Lymphocyte Ratio (NLR), Monocyte to Lymphocyte Ratio (MLR) and Platelet to Lymphocyte Ratio (PLR) on Long-Term Survival in Off-Pump Coronary Artery Bypass Grafting (OPCAB) Procedures

Urbanowicz

Olasińska-Wiśniewska

Michalak

et al. 2021

Biology

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Background: Cardiovascular diseases, apart from commonly known risk factors, are related to inflammation. There are several simple novel markers proposed to present the relation between inflammatory reactions activation and atherosclerotic changes. They are easily available from whole blood count and include neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), and platelets to lymphocyte ratio (PLR). The RDW results were excluded from the analysis. Method and results: The study based on retrospective single-centre analysis of 682 consecutive patients (131 (19%) females and 551 (81%) males) with median age of 66 years (60–71) who underwent off-pump coronary artery bypass grafting (OPCAB) procedure. During the median 5.3 +/− 1.9 years follow-up, there was a 87% cumulative survival rate. The laboratory parameters including preoperative MLR > 0.2 (HR 2.46, 95% CI 1.33–4.55, p = 0.004) and postoperative NLR > 3.5 (HR 1.75, 95% CI 1.09–2.79, p = 0.019) were found significant for long-term mortality prediction in multivariable analysis. Conclusion: Hematological indices NLR and MLR can be regarded as significant predictors of all-cause long-term mortality after OPCAB revascularization. Multivariable analysis revealed preoperative values of MLR > 0.2 and postoperative values of NLR > 3.5 as simple, reliable factors which may be applied into clinical practice for meticulous postoperative monitoring of patients in higher risk of worse prognosis.

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“…Considering that inflammation has a tight link with the onset, development, and progression of AKI, plenty of inflammation-based biomarkers have been established to have diagnostic and prognostic significance in various kinds of patients. [8][9][10][11][12][13] In addition, recent studies have also indicated that platelet-albumin ratio (PAR), an indication of the inflammatory response, may be employed as a predictive marker or progression factor for various kinds of cancers. [14][15][16] However, the association between PAR and CSA-AKI for critical care patients has not previously been explored.…”

Section: Introductionmentioning

confidence: 99%

Predictive Value of Platelet-to-Albumin Ratio (PAR) for the Cardiac-Associated Acute Kidney Injury and Prognosis of Patients in the Intensive Care Unit

He¹,

Wang²,

Wang³

et al. 2022

IJGM

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Background:We wanted to demonstrate whether the initial platelet-to-albumin ratio (PAR) had predictive value for cardiac surgeryassociated acute kidney injury (CSA-AKI) and prognosis of critical care patients. Methods: This is an observational and multi-center study from the MIMIC-IV database, the eICU-CRD database as well as CS patients at our institution. Logistic regression and Cox regression analyses were applied to determine the predictive value for CSA-AKI and in-hospital mortality. LASSO and SVM-RFE models were then employed to discover the coincident variables connected with CSA-AKI. The main objective of this research was the incidence of CSA-AKI, whereas the secondary endpoint was in-hospital death. Results: The higher PAR value (≥4.67) had a higher risk of CSA-AKI (adjusted OR = 4.02, 95% CI 3.41-4.75, P < 0.001) and in-hospital mortality (HR = 2.41 95% CI 1.44-4.03, P = 0.001) after adjusted for other confounding factors including patients with or without chronic kidney disease. The proposed nomogram based on PAR and others clinical factors selected by LASSO and SVM-RFE models for CSA-AKI had the C-index 0.821 (95% CI 0.807-0.834), 0.808 (95% CI 0.787-0.829), 0.745 (95% CI 0.728-0.762), and 0.826 (95% CI 0.753-0.899) in these cohorts, respectively. The nomogram exhibited both remarkable calibration capacity and therapeutic helpfulness in all groups. Conclusion: PAR is a relative excellent measure for the event AKI and prognosis of ICU patients who undergone CS. The suggested nomogram based on PAR resulted in an accurate prediction for the detection of critical care patients with CSA-AKI.

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Are Pre and Postoperative Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio Associated with Early Postoperative AKI Following CABG?

Cited by 12 publications

References 5 publications

Preoperative Lymphocyte-to-Monocyte Ratio as a Prognostic Predictor of Long-Term Mortality in Cardiac Surgery Patients: A Propensity Score Matching Analysis

Preoperative Lymphocyte-to-Monocyte Ratio as a Prognostic Predictor of Long-Term Mortality in Cardiac Surgery Patients: A Propensity Score Matching Analysis

The Prognostic Significance of Neutrophil to Lymphocyte Ratio (NLR), Monocyte to Lymphocyte Ratio (MLR) and Platelet to Lymphocyte Ratio (PLR) on Long-Term Survival in Off-Pump Coronary Artery Bypass Grafting (OPCAB) Procedures

Predictive Value of Platelet-to-Albumin Ratio (PAR) for the Cardiac-Associated Acute Kidney Injury and Prognosis of Patients in the Intensive Care Unit

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