The Prognostic Value of C-reactive Protein to Albumin Ratio in Patients with Isolated Degenerative Aortic Valve Stenosis Undergoing Surgical Aortic Valve Replacement

Kahraman, Serkan; Doğan, Arda Can; Demirci, Gökhan; Demir, Ali; Yılmaz, Emre; Ağuş, Hicaz Zencirkıran; Kalkan, Ali Kemal; Uzun, Fatih; Ertürk, Mehmet

doi:10.21470/1678-9741-2019-0114

Cited by 15 publications

(16 citation statements)

References 23 publications

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“…Aortic stenosis (AS) is the most common form of degenerative valvular heart disease and surgical valve replacement (sAVR) continues to be the gold standard therapy in severe symptomatic AS, especially in developing countries due to its increasing prevalence. 1 Although several prognostic risk factors of sAVR were described, [2][3][4][5][6][7][8][9][10][11] new prognostic markers are of great interest.…”

Section: Introductionmentioning

confidence: 99%

The prognostic value of fQRSTa in patients with aortic stenosis undergoing surgical aortic valve replacement

et al. 2020

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Background Surgical aortic valve replacement (sAVR) is the ultimate therapy for severe aortic stenosis (AS) in suitable patients. Prognostic factors of sAVR are great interest in recent studies. Frontal QRS‐T angle (fQRSTa) is a novel marker of ventricular repolarization abnormalities. In this study, we aimed to investigate the prognostic value of fQRSTa in patients with severe symptomatic AS undergoing sAVR. Methods A total of 372 patients with severe degenerative AS who underwent successful sAVR were included in this retrospective study. Then, patients were divided into two groups: patients with narrow fQRSTa (≤90°) as group 1 and wide fQRSTa (>90°) as group 2. Perioperative and postoperative clinical evaluation and time of death were recorded from all subjects. Results The incidence of total mortality was higher in patients with wider fQRSTa (13.8% [15]; 4.9% [9], P = .013) compared to patients with narrow fQRSTa. In multivariate logistic regression analysis, advanced age (odds ratio [OR] = 1.054; 95% confidence interval [CI] = 1.004‐1.106; P = .034), dyspnea (OR = 7.687; 95% CI = 2.296‐25.729; P = .001), lower efection fraction (OR = 0.924; 95% CI = 0.884‐0.966; P = .001), in‐hospital duration (OR = 1.051; 95% CI = 1.016‐1.088; P = .004) and wider fQRSTa (OR = 4.029; 95% CI = 1.383‐11.740; P = .011) were found to be independent predictors of mortality. Additionally, a Kaplan‐Meier survival analysis also revealed that long‐term survival was found to be significantly decreased in patients with wider fQRSTa (log‐rank P = .014). Conclusion fQRSTa was related with poor prognosis in patients with AS undergoing sAVR. fQRSTa was also an independent predictor of mortality in this population.

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Section: Introductionmentioning

confidence: 99%

The prognostic value of fQRSTa in patients with aortic stenosis undergoing surgical aortic valve replacement

et al. 2020

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“…Most observational studies and clinical trials have used CRP as a biochemical marker of systemic inflammation that is produced following stimulation by various cytokines that can be drivers of an acute response to infection, ischemia, trauma, and other inflammatory conditions such as physical inactivity [44][45][46]. Contrary to CRP, albumin is reduced in the chronic inflammatory process; therefore, the CRP to albumin ratio can be a more sensitive marker to predict inflammation than CRP or albumin rates alone, due to their two different directions (increased CRP and decreased albumin) [47]. Systemic inflammation, and a high concentration of IL-6 and TNFα in particular, not only reduces albumin synthesis but also increases its degradation and promotes its transcapillary leakage.…”

Section: Discussionmentioning

confidence: 99%

The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging

et al. 2021

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One of the latest theories on ageing focuses on immune response, and considers the activation of subclinical and chronic inflammation. The study was designed to explain whether anti-inflammatory diet and lifestyle exercise affect an inflammatory profile in the Polish elderly population. Sixty individuals (80.2 ± 7.9 years) were allocated to a low-grade inflammation (LGI n = 33) or high-grade inflammation (HGI n = 27) group, based on C-reactive protein concentration (<3 or ≥3 mg/L) as a conventional marker of systemic inflammation. Diet analysis focused on vitamins D, C, E, A, β-carotene, n-3 and n-6 PUFA using single 24-h dietary recall. LGI demonstrated a lower n-6/n-3 PUFA but higher vitamin D intake than HGI. Physical performance based on 6-min walk test (6MWT) classified the elderly as physically inactive, whereby LGI demonstrated a significantly higher gait speed (1.09 ± 0.26 m/s) than HGI (0.72 ± 0.28 m/s). Circulating interleukins IL-1β, IL-6, IL-13, TNFα and cfDNA demonstrated high concentrations in the elderly with low 6MWT, confirming an impairment of physical performance by persistent systemic inflammation. These findings reveal that increased intake of anti-inflammatory diet ingredients and physical activity sustained throughout life attenuate progression of inflammaging in the elderly and indicate potential therapeutic strategies to counteract pathophysiological effects of ageing.

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“…1 In previous studies, several prognostic markers were described to predict high risk severe AS patient. 2,3 Ventricular repolarization abnormalities were studied in several cardiac diseases. Thus, it is well known that repolarization abnormalities were related with adverse cardiovascular events.…”

Section: Due To the Ageing Population Degenerative Aortic Valve Steno...mentioning

confidence: 99%

“…Although it is associated with increased rate of mortality and poorer prognosis, surgical aortic valve replacement (AVR) is the ultimate therapy for severe symptomatic AS 1 . In previous studies, several prognostic markers were described to predict high risk severe AS patient 2,3 …”

Section: Introductionmentioning

confidence: 99%

Novel markers of ventricular repolarization are associated with mortality in patients undergoing surgical aortic valve replacement for severe aortic stenosis

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Demir

Bulut

et al. 2021

Journal of Cardiac Surgery

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Introduction: Aortic stenosis (AS) is the most common degenerative valvular heart disease that can affect left ventricular functions. Tp-e interval and Tp-e/QT ratio is a novel repolarization marker which is associated with adverse cardiovascular events in several cardiovascular diseases. In our study, our aim is to investigate the prognostic effect of Tp-e interval, Tp-e/QT and Tp-e/QTc ratios on mortality in patients who underwent successful surgical aortic valve replacement (AVR).Methods: A total of three hundred seventy-five patients undergoing successful surgical AVR were included in this study. Then, patients were divided into two groups according to mortality as group 1 without mortality (342 patients) and group 2 with mortality (33 patients). Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were calculated for both groups.Results: Tp-e interval (71 (63.7-77); 86 (84-88), p < .001), Tp-e/QT ratio (0.19 (0.17-0.20); 0.23 (0.22-0.23), p < .001) and Tp-e/QTc ratio (0.17 ± 0.02; 0.21 ± 0.01, p < .001) were higher in group 2 compared to group 1. In multivariate logistic regression analyses Tp-e interval (odds ratio [OR]: 1.315, 95% confidence interval [CI]:

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The Prognostic Value of C-reactive Protein to Albumin Ratio in Patients with Isolated Degenerative Aortic Valve Stenosis Undergoing Surgical Aortic Valve Replacement

Cited by 15 publications

References 23 publications

The prognostic value of fQRSTa in patients with aortic stenosis undergoing surgical aortic valve replacement

The prognostic value of fQRSTa in patients with aortic stenosis undergoing surgical aortic valve replacement

The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging

Novel markers of ventricular repolarization are associated with mortality in patients undergoing surgical aortic valve replacement for severe aortic stenosis

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