Association of Platelet to Lymphocyte and Neutrophil to Lymphocyte Ratios with In-Hospital Mortality in Patients with Type A Acute Aortic Dissection

Abstract

ObjectiveTo evaluate the relationship between neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) with in-hospital mortality in type A acute aortic dissection (AAD).MethodsA total of 96 patients who presented to the emergency department between January 2013 and June 2018 with a diagnosis of type A AAD were enrolled in this study. White blood cell count subtypes such as NLR and PLR were calculated at the time of admission. The end point was in-hospital mortality.ResultsOf the 96 type A AAD patients included in this analysis, 17 patients (17.7%) died during hospitalization. NLR and PLR were significantly elevated in patients with type A AAD (P<0.001 and <0.001, respectively). Based on the receiver operating characteristic curve, the best NLR cut-off value to predict in-hospital mortality was 9.74, with 70.6% sensitivity and 76.8% specificity, whereas the best PLR cut-off value was 195.8, with 76.5% sensitivity and 78.1% specificity.ConclusionAdmission NLR and PLR levels were important risk factors and independently associated with in-hospital mortality of type A AAD patients.

Relationship of Platelet Counts and Inflammatory Markers to 30-Day Mortality Risk in Patients with Acute Type A Aortic Dissection

“…Both inflammation and hemostatic play important roles in the pathogenesis of AAAD [2]. Various inflammatory and hemostatic biomarkers have attracted more and more attention as prognostic indicators in AAAD patients [3][4][5][6]. Risk stratification using such biomarkers can help predict patients' outcome which is important for the healthcare providers to deliver appropriate therapeutic management [7].…”

Admission Time and Surgical Technique are Important in Aortic Dissection Treatment Results

“…I have read the article by Bedel et al [ 1 ] , entitled “Association of Platelet to Lymphocyte and Neutrophil to Lymphocyte Ratios with In-Hospital Mortality in Patients with Type A Acute Aortic Dissection” with great interest. First of all, I congratulate the authors for their invaluable contribution to the literature.…”

“…Total surgery was performed in 86 patients and mortality occurred in 7 patients who underwent surgery. However, postoperative mortality and mortality without surgery were evaluated in the same group and the relationship between blood parameters were investigated [ 1 ] . As we mentioned in the studies above [ 3 , 4 ] , it may be misleading to evaluate mortality only with reference blood parameters when surgery is applied to patients with aortic dissection.…”

Preoperative Lymphocyte-To-Monocyte Ratio as a Prognostic Predictor of Long-term Mortality Among Cardiac Surgery Patients: A Propensity Score Matching Analysis Based on a 4-year Follow-up Cohort

“…and related surgeries. For example, for cardiac surgery patients, the value of the neutrophil-to-lymphocyte ratio (NLR) can serve as a predictor of early and late mortality (5) (6), postoperative acute kidney injury (7), and postoperative atrial brillation (8,9), while the platelet-to-lymphocyte ratio (PLR) has been reported to be a predictor of prognosis in patients with aortic dissection (10).…”