Thoracoabdominal Aortic Aneurysm in a HIV-positive Patient

Lucas, Márcio Luı́s; Binotto, Ívia; Behar, Paulo Renato Petersen; Erling, Nilon; Lichtenfels, Eduardo; Aerts, Newton

doi:10.21470/1678-9741-2016-0045

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Until recently, there were only rare case reports linking various aortic pathologies to HIV infection. 33,34 In 2021, a study reported a higher prevalence of AAA among PWH compared with matched controls. 12 In contrast to our study, the COCOMO study (Copenhagen Comorbidity in HIV Infection) assessed the prevalence of both AAA and thoracic aortic aneurysms using screening computed tomography imaging of the aorta.…”

Section: Discussionmentioning

confidence: 99%

Association of HIV Infection and Incident Abdominal Aortic Aneurysm Among 143 001 Veterans

Filipkowski,

Kundu,

Eden

et al. 2023

Circulation

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BACKGROUND: People with HIV (PWH) have an increased risk of cardiovascular disease. Previous cross-sectional data suggest there is a higher prevalence of abdominal aortic aneurysm (AAA) in PWH than in those without HIV. Whether PWH have an increased risk of incident AAA compared with those without HIV is unknown. METHODS: We analyzed data among participants without prevalent AAA from the Veterans Aging Cohort Study, a prospective, observational, longitudinal cohort of veterans with HIV matched 1:2 with veterans without HIV infection. We calculated AAA rates by HIV status and assessed the association between HIV infection and incident AAA using Cox proportional hazards models. We defined AAA using the International Classification of Diseases, 9th or 10th revision, or Current Procedural Terminology codes and adjusted all models for demographic characteristics, cardiovascular disease risk factors, and substance use. Secondary analyses examined the association between time-varying CD4+ T-cell count or HIV viral load and incident AAA. RESULTS: Among 143 001 participants (43 766 with HIV), over a median follow-up of 8.7 years, there were 2431 incident AAA events (26.4% among PWH). Rates of incident AAA per 1000 person-years were similar among PWH (2.0 [95% CI, 1.9–2.2]) and people without HIV (2.2 [95% CI, 2.1–2.3]). There was no evidence that HIV infection increased the risk of incident AAA compared with no HIV infection (adjusted hazard ratio, 1.02 [95% CI, 0.92–1.13]). In adjusted analyses with time-varying CD4+ T-cell counts or HIV viral load, PWH with CD4+ T-cell counts <200 cells/mm 3 (adjusted hazard ratio, 1.29 [95% CI, 1.02–1.65]) or HIV viral load ≥500 copies/mL (adjusted hazard ratio, 1.29 [95% CI, 1.09–1.52]) had an increased risk of AAA compared with those without HIV. CONCLUSIONS: HIV infection is associated with an increased risk of AAA among those with low CD4+ T-cell counts or elevated HIV viral load over time.

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Section: Discussionmentioning

confidence: 99%

Association of HIV Infection and Incident Abdominal Aortic Aneurysm Among 143 001 Veterans

Filipkowski,

Kundu,

Eden

et al. 2023

Circulation

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HIV-associated Extracranial Arterial Aneurysms: A Systematic Review

Kariyanna

Yager

Salciccioli

et al. 2020

AJMCR

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Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) has been found to be associated with an increased risk of cardiovascular disease, and the development of arterial aneurysms in particular, intracranial aneurysms. In this review, we will review the reported HIV-associated extracranial aneurysms (HECAA) and their possible association with HIV/AIDS. We will discuss the proposed pathogenetic pathways leading to arterial aneurysms. HECAA, a subset of HIV/AIDS-associated arterial aneurysm (HAA), is more commonly seen in the adult population and in those with lower CD4+ T-cell counts and higher HIV viral loads. There also appears to be an advantage to early diagnosis of HECAA. There are viable treatment options available, as 61.4% of patients with HECAA underwent a corrective procedure. Furthermore, the mortality rate of 1.75% in HECAA was much lower when compared to HICAA.

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Thoracoabdominal Aortic Aneurysm in a HIV-positive Patient

Cited by 2 publications

References 8 publications

Association of HIV Infection and Incident Abdominal Aortic Aneurysm Among 143 001 Veterans

Association of HIV Infection and Incident Abdominal Aortic Aneurysm Among 143 001 Veterans

HIV-associated Extracranial Arterial Aneurysms: A Systematic Review

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