Effect of metronidazole on placental and fetal development in albino rats

Silva, Welma Emídio da; Melo, Ismaela Maria Ferreira de; Albuquerque, Yuri Mateus Lima de; Mariano, Aline Ferreira da Silva; Wanderley‐Teixeira, Valéria; Teixeira, Álvaro Aguiar Coelho

doi:10.21451/1984-3143-ar2018-0149

Cited by 5 publications

(1 citation statement)

References 35 publications

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“…In addition, Metronidazole was associated with the reduction of reproductive hormones such as follicle-stimulating hormones, luteinizing hormones, and massive degeneration of the germ cells at stage VII 5 . The effect of Metronidazole on the placenta and fetal development in rats revealed that 130mg/kg was toxic since it reduced the number of implanted embryos, weight, and components of the placenta and neonates, suggesting cautious use in pregnancy on prolonged use 7 .…”

Section: Introduction 1backgroundmentioning

confidence: 99%

Metronidazole (Flagyl) use as an emergency contraceptive and associated factors among University female students in Dodoma region Tanzania: A descriptive crossectional study

Samson¹,

Sumari²,

Ndesendo³

et al. 2023

Preprint

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Background: Metronidazole is known for its therapeutic effect as antibacterial and anti-parasitic. However, its toxicity on the reproductive system remains not well studied. Its use in rodents was associated with toxic effects on the reproductive system, including hormonal alterations, reduced number of fertile cells, and effects on implantations. Its use at a therapeutic dose among humans has been associated with an increased risk of spontaneous abortion. The effects on the reproductive system in humans may result in misconceptions about contraceptive effects hence sexually active individuals like students who, for any reason, fail to access safe contraceptive services use any possible methods to protect them from conception. This study explored if Metronidazole (Flagyl) is unofficially used as an emergency contraceptive among female university students and its associated factors for possible interventions. Methods: This quantitative cross-sectional study involved 470 participants conveniently recruited from three educational institutions in the Dodoma Municipal, Dodoma region. Collected data were analyzed using SPSS version 25, descriptive and analytical statistical analysis was done to determine the association and relationship between the study variables, and p<0.05 was used to determine statistical significance. Results: The study revealed exciting findings: among the participants with experience using emergency contraceptives, 169(62.4%) reported using Metronidazole as an emergency contraceptive. Notably, 345(73.4%) of the study participants said they had ever heard someone use Metronidazole for contraception, especially their peers. Furthermore, an increase in the year of study was significantly associated with reduced use of Metronidazole as an emergency contraceptive (B= [-0.45], p= [0.02]). Furthermore, an increase in age, studying in non-medical college/university, the experience of using contraceptive methods, and hearing someone ever used Metronidazole were found to be positively associated with its use as an emergency contraceptive, although not statistically significant. Conclusion: Metronidazole was found to be used as an emergency contraceptive in high doses, different factors associated with its use, and reasons influencing its use. Further research may be done to explore the toxicological effect of high doses of Metronidazole as a contraception in human subjects.

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Section: Introduction 1backgroundmentioning

confidence: 99%

Metronidazole (Flagyl) use as an emergency contraceptive and associated factors among University female students in Dodoma region Tanzania: A descriptive crossectional study

Samson¹,

Sumari²,

Ndesendo³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Emergency contraceptive use of Metronidazole among University female students in Dodoma region of Tanzania: a descriptive cross-sectional study

Samson,

Sumari,

Ndesendo

et al. 2023

Contracept Reprod Med

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Background Metronidazole is known for its therapeutic effect as antibacterial and anti-parasitic. However, its toxicity on the reproductive system remains unclear. Metronidazole use in rodents is associates with toxic effects on the reproductive system, including hormonal alterations, reduced number of fertile cells and reduced sites for implantation, size of the placental disc area, constituent elements of the labyrinth, and spongiotrophoblast layers. Its use at a therapeutic dose among humans has been associated with an increased risk of spontaneous abortion. The effects on the reproductive system in humans may result in misconceptions about contraceptive effects hence sexually active individuals like students who, for any reason, fail to access safe contraceptive services use any possible methods to protect them from conception. This study aims to investigate the unofficial (un-prescribed) use of Metronidazole as an emergency contraceptive and some of its associated factors. Methods This quantitative cross-sectional study involved 470 participants where stratified random sampling technique was used to obtain the sample from three educational institutions in the Dodoma Municipal, Dodoma region. Collected data were analyzed using SPSS version 25, descriptive statistical analysis was done to determine frequencies, percentages, and association, p < 0.05 was used to determine statistical significance. Further analysis using Multivariate binary logistic regression was done to determine the nature of the association between the study variables. Results The finding shows that 169(62.4%) use Metronidazole as an emergency contraceptive. Notably, 345(73.4%) stated that they had ever heard someone use Metronidazole for contraception, especially their peers. Furthermore, an increase in the year of study was significantly associated with reduced use of Metronidazole as an emergency contraceptive (B = [-0.45], p = [0.02]). Furthermore, an increase in age, studying in non-medical college/university, the experience of using contraceptive methods, and hearing someone ever used Metronidazole was found to be positively associated with its use as an emergency contraceptive, although not statistically significant. Conclusion Metronidazole was found to be used as an emergency contraceptive in high doses, different factors associated with its use, and reasons influencing its use. Further research may be done to explore the toxicological effect of high doses of Metronidazole as a contraception and compare the efficiency of Metronidazole over other emergency contraceptives.

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Effect of the Aqueous Extract of Chrysobalanus icaco Leaves on Maternal Reproductive Outcomes and Fetal Development in Wistar Rats

Rodrigues,

Oliveira,

Lima

et al. 2023

CIMB

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Toxicological studies on medicinal plants are essential to ensure their safety and effectiveness in treating various diseases. Despite the species Chrysobalanus icaco L. being popularly used in the treatment of several diseases due to the pharmacological properties of its bioactive compounds, there are few studies in the literature regarding its toxicity regarding reproduction. Therefore, the purpose of this study was to assess the potential embryotoxic and teratogenic effects of the aqueous extract of C. icaco leaves (AECi) on Wistar rats. Animals were given AECi at doses of 100, 200, and 400 mg/kg during the pre-implantation and organogenesis periods. Data were analyzed using ANOVA followed by Tukey’s test and Kruskal–Wallis. Pregnant rats treated during the pre-implantation period showed no signs of reproductive toxicity. Rats that received AECi at 100, 200, and 400 mg/kg during organogenesis did not exhibit any signs of maternal systemic toxicity or significant differences in gestational and embryotoxic parameters. Some skeletal changes were observed in the treated groups. Therefore, it can be suggested that AECi at doses of 100, 200, and 400 mg/kg is safe for treated animals and does not induce reproductive toxicity under the experimental conditions applied, but it also caused low systemic toxicity.

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Effect of metronidazole on placental and fetal development in albino rats

Cited by 5 publications

References 35 publications

Metronidazole (Flagyl) use as an emergency contraceptive and associated factors among University female students in Dodoma region Tanzania: A descriptive crossectional study

Metronidazole (Flagyl) use as an emergency contraceptive and associated factors among University female students in Dodoma region Tanzania: A descriptive crossectional study

Emergency contraceptive use of Metronidazole among University female students in Dodoma region of Tanzania: a descriptive cross-sectional study

Effect of the Aqueous Extract of Chrysobalanus icaco Leaves on Maternal Reproductive Outcomes and Fetal Development in Wistar Rats

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