LncRNA XIST promotes neovascularization in diabetic retinopathy by regulating miR-101-3p/VEGFA
Weina Fu,
Yunyan Ye,
Feng Hu
Abstract:Objective:
This study sought to investigate the regulation of long noncoding RNA (lncRNA) XIST on the microRNA (miR)-101-3p/vascular endothelial growth factor A (VEGFA) axis in neovascularization in diabetic retinopathy (DR).
Materials and methods:
Serum of patients with DR was extracted for the analysis of XIST, miR-101-3p, and VEGFA expression levels. High glucose (HG)-insulted HRMECs and DR model rats were treated with lentiviral vectors. MTT, transwell, and tube for… Show more
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