Obesity, diabetes, and cancer: epidemiology, pathophysiology, and potential interventions

Mesquita, Leonardo de Andrade; Wayerbacher, Laura Fink; Schwartsmann, Gilberto; Gerchman, Fernando

doi:10.20945/2359-3997000000647

Archives of Endocrinology and Metabolism

2023

DOI: 10.20945/2359-3997000000647

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Obesity, diabetes, and cancer: epidemiology, pathophysiology, and potential interventions

Leonardo de Andrade Mesquita¹,

Laura Fink Wayerbacher²,

Gilberto Schwartsmann³

et al.

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2024

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Cited by 4 publications

References 124 publications

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Flavonoids with lipase inhibitory activity from lemon squeezing waste: isolation, multispectroscopic and in silico studies

Cardullo,

Calcagno,

Pulvirenti

et al. 2024

J Sci Food Agric

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BACKGROUNDObesity is recognized as a lifestyle‐related disease and the main risk factor for a series of pathological conditions, including cardiovascular diseases, hypertension and type 2 diabetes. Citrus limon is an important medicinal plant, and its fruits are rich in flavonoids investigated for their potential in managing obesity. In the present work, a green extraction applied to lemon squeezing waste (LSW) was optimized to recover pancreatic lipase (PL) inhibitors.RESULTSThe microwave‐assisted procedure yielded an extract with higher lipase inhibitory activity than those obtained by maceration and ultrasound. The main compounds present in the extract were identified by high‐performance liquid chromatographic–mass spectrometric analysis, and hesperidin, eriocitrin and 4′‐methyllucenin II were isolated. The three compounds were evaluated for in vitro PL inhibitory activity, and 4′‐methyllucenin II resulted in the most promising inhibitor (IC50 = 12.1 μmol L−1; Ki = 62.2 μmol L−1). Multispectroscopic approaches suggested the three flavonoids act as competitive inhibitors and the binding studies indicated a greater interaction between PL and 4′‐methyllucenin II. Docking analysis indicated the significant interactions of the three flavonoids with the PL catalytic site.CONCLUSIONThe present work highlights flavonoid glycosides as promising PL inhibitors and proposes LSW as a safe ingredient for the preparation of food supplements for managing obesity. © 2024 Society of Chemical Industry.

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Flavonoids with lipase inhibitory activity from lemon squeezing waste: isolation, multispectroscopic and in silico studies

Cardullo,

Calcagno,

Pulvirenti

et al. 2024

J Sci Food Agric

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Integrated transcriptomics and metabolomics reveal the mechanism of intestinal damage upon acute patulin exposure in mice

Zhang,

Yan,

Chang

et al. 2024

Ecotoxicology and Environmental Safety

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Stachyose ameliorates obesity-related metabolic syndrome via improving intestinal barrier function and remodeling gut microbiota

He,

Wang,

et al. 2024

Journal of Functional Foods

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Obesity, diabetes, and cancer: epidemiology, pathophysiology, and potential interventions

Cited by 4 publications

References 124 publications

Flavonoids with lipase inhibitory activity from lemon squeezing waste: isolation, multispectroscopic and in silico studies

Flavonoids with lipase inhibitory activity from lemon squeezing waste: isolation, multispectroscopic and in silico studies

Integrated transcriptomics and metabolomics reveal the mechanism of intestinal damage upon acute patulin exposure in mice

Stachyose ameliorates obesity-related metabolic syndrome via improving intestinal barrier function and remodeling gut microbiota

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