Association of methylenetetrahydrofolate reductase ( MTHFR ) gene polymorphisms (C677T and A1298C) with thyroid dysfunction: A meta-analysis and trial sequential analysis

Rui, Yang; Pu, Danhua; Tan, Ruoyun; Wu, Jie

doi:10.20945/2359-3997000000471

Cited by 3 publications

(4 citation statements)

References 46 publications

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“…Because methyltransferases rely on the biochemical integrity of methylation reactions in the body to transfer a single-carbon unit, the completeness of that conversion will be determined by an individual’s gene variants related to that enzyme. Methylation inefficiencies due to single nucleotide polymorphisms (SNPs) in methylation-related enzymes like 5,10-methylenetetrahydrofolate reductase (C677T) are clinically relevant in various disease states [ 202 , 203 , 204 , 205 ]. Unfortunately, SNPs specifically related to the ASMT enzyme have not been extensively explored in humans but would be an excellent area for translational research that could encompass clinical identification of SNPs along with nutrient modifications for therapeutic intervention [ 206 ].…”

Section: Therapeutic Considerationsmentioning

confidence: 99%

Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements

Minich

Henning²,

Darley

et al. 2022

Nutrients

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Melatonin has become a popular dietary supplement, most known as a chronobiotic, and for establishing healthy sleep. Research over the last decade into cancer, Alzheimer’s disease, multiple sclerosis, fertility, PCOS, and many other conditions, combined with the COVID-19 pandemic, has led to greater awareness of melatonin because of its ability to act as a potent antioxidant, immune-active agent, and mitochondrial regulator. There are distinct similarities between melatonin and vitamin D in the depth and breadth of their impact on health. Both act as hormones, affect multiple systems through their immune-modulating, anti-inflammatory functions, are found in the skin, and are responsive to sunlight and darkness. In fact, there may be similarities between the widespread concern about vitamin D deficiency as a “sunlight deficiency” and reduced melatonin secretion as a result of “darkness deficiency” from overexposure to artificial blue light. The trend toward greater use of melatonin supplements has resulted in concern about its safety, especially higher doses, long-term use, and application in certain populations (e.g., children). This review aims to evaluate the recent data on melatonin’s mechanisms, its clinical uses beyond sleep, safety concerns, and a thorough summary of therapeutic considerations concerning dietary supplementation, including the different formats available (animal, synthetic, and phytomelatonin), dosing, timing, contraindications, and nutrient combinations.

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Section: Therapeutic Considerationsmentioning

confidence: 99%

Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements

Minich

Henning²,

Darley

et al. 2022

Nutrients

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“…During canine hypothyroidism, as in humans, the concentration of Hcy was negatively correlated with the concentration of total thyroxine (TT4) [ 42 , 44 , 45 ]. It is partially explained by the positive correlation between thyroid hormone levels and the activity of methylenetetrahydrofolate reductase (MTHFR), which is involved in the (re)methylation of Hcy to methionine [ 46 , 47 , 48 , 49 ]. This relationship indicates a likely role of thyroid gland disorders in developing homocysteine-dependent pathologies [ 44 , 50 ].…”

Section: Homocysteine In Pets and Farm Animalsmentioning

confidence: 99%

Homocysteine—Potential Novel Diagnostic Indicator of Health and Disease in Horses

Gołyński

Metyk

Ciszewska

et al. 2023

Animals

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Homocysteine is an endogenous, non-protein sulfuric amino acid, an intermediate metabolite formed by the methionine transmethylation reaction. Its elevated serum concentration in humans, hyperhomocysteinemia, is a sensitive indicator and a risk factor for coagulation disorders, cardiovascular diseases and dementia. However, the role of homocysteine in veterinary species has not been unequivocally established. Although some research has been conducted in dogs, cats, cattle and pigs, relatively few studies on homocysteine have been conducted in horses. So far, it has been established in this species that homocysteine has an atherogenic effect, plays a role in early embryo mortality and is responsible for the induction of oxidative stress. These preliminary findings support establishing a reference range in a normal population of horses, including horses in training and merit further investigations into the role of this amino acid in health and disease in this species.

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confidence: 99%

“…Various comorbidities like intellectual disability, congenital heart defects (CHD), gastrointestinal disorders, celiac disease, thyroid disease, and otitis media occur commonly in DS patients. A metaanalysis of 817 patients and 566 controls found that MTHFR C677T is a risk factor for hypothyroidism (Yang et al 2022). Similarly, it has been found that MTHFR A1298C and MTHFR C677T are associated with the risk of CHD (Zidan et al 2013).Studies on MTHFR polymorphism in individuals with Down syndrome are lacking, though there are multiple studies on MTHFR polymorphisms as a maternal risk factor for DS (Kedar et al 2019;Brandalize et al 2009;Meguid et al 2008).…”

mentioning

confidence: 99%

Congenital heart defects and hypothyroidism in Down syndrome patients with common MTHFR polymorphisms

Garg,

Patial,

Kapoor

et al. 2024

Preprint

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MTHFR is an essential enzyme in the folate pathway. Down syndrome (DS), which affects 1 in 700 live births, is common chromosomal aneuploidy with documented dysregulation in cellular folate pathway. Homocysteine accumulation is caused by dysregulation in MTHFR activity and hyperhomocysteinemia is a stand-alone risk factor for a number of vascular diseases. There is an association between the MTHFR polymorphisms C677T and A1298C with stroke, thromboembolism, and hypothyroidism. Patients with Down syndrome frequently have a variety of co-morbidities, including intellectual disability, congenital heart defects, gastrointestinal problems including celiac disease, thyroid disease, and early Alzheimer disease,. However, no comprehensive study has been conducted to ascertain whether how MTHFR polymorphisms, homocysteine, and cysteine levels are correlated to different co-morbidities in Down syndrome. Therefore, in this study, we examined common polymorphisms in the MTHFR gene as well as the levels of cysteine and homocysteine in DS patients with various comorbidities and found that MTHFR C677T and MTHFR A1298C are over-represented in DS patients than in controls. Also MTHFRC677T is linked to hypothyroidism in DS patients, while MTHFR AA1298AC and MTHFRAA1298CC are linked to both hypothyroidism and CHD in DS patients. Hence this study would enable better prognostication and counseling for DS children and appropriate monitoring and follow up.

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Association of methylenetetrahydrofolate reductase ( MTHFR ) gene polymorphisms (C677T and A1298C) with thyroid dysfunction: A meta-analysis and trial sequential analysis

Cited by 3 publications

References 46 publications

Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements

Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements

Homocysteine—Potential Novel Diagnostic Indicator of Health and Disease in Horses

Congenital heart defects and hypothyroidism in Down syndrome patients with common MTHFR polymorphisms

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