Inflammatory mediators in polycystic ovary syndrome: the case of interleukin-18

Spritzer, Poli Mara

doi:10.20945/2359-3997000000455

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…ovarian syndromea condition strongly linked to T1D (158,159). Taken together, the results of these numerous animal and human studies suggest that IL-18 may play a pathogenic role in T1D through its interferon gamma (IFN-g)-inducing potential.…”

Section: Type 1 Diabetes (T1d)mentioning

confidence: 98%

“…Similar findings were observed after treatment with HIV-1 protease inhibitors in rats ( 157 ). IL-18 has also been shown to be a mediator of polycystic ovarian syndrome – a condition strongly linked to T1D ( 158 , 159 ). Taken together, the results of these numerous animal and human studies suggest that IL-18 may play a pathogenic role in T1D through its interferon gamma (IFN- γ)-inducing potential.…”

Section: Pathophysiological Autoimmune Conditions Associated With Il-18mentioning

confidence: 99%

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Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment

et al. 2022

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Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against infections and regulates the innate and acquired immune response. IL-18 is produced by both hematopoietic and non-hematopoietic cells, including monocytes, macrophages, keratinocytes and mesenchymal cell. IL-18 could potentially induce inflammatory and cytotoxic immune cell activities leading to autoimmunity. Its elevated levels have been reported in the blood of patients with some immune-related diseases, including rheumatoid arthritis, systemic lupus erythematosus, type I diabetes mellitus, atopic dermatitis, psoriasis, and inflammatory bowel disease. In the present review, we aimed to summarize the biological properties of IL-18 and its pathological role in different autoimmune diseases. We also reported some monoclonal antibodies and drugs targeting IL-18. Most of these monoclonal antibodies and drugs have only produced partial effectiveness or complete ineffectiveness in vitro, in vivo and human studies. The ineffectiveness of these drugs targeting IL-18 may be largely due to the loophole caused by the involvement of other cytokines and proteins in the signaling pathway of many inflammatory diseases besides the involvement of IL-18. Combination drug therapies, that focus on IL-18 inhibition, in addition to other cytokines, are highly recommended to be considered as an important area of research that needs to be explored.

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Section: Type 1 Diabetes (T1d)mentioning

confidence: 98%

Section: Pathophysiological Autoimmune Conditions Associated With Il-18mentioning

confidence: 99%

Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment

et al. 2022

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“…1C). Cardiovascular disease, insulin resistance, diabetes mellitus, and obesity are associated with inflammation and are considered metabolic aspects of PCOS [38,39] . In many cases, inflammation directly stimulates polycystic ovaries to produce androgens in patients with PCOS [40] .…”

Section: Low-grade Inflammationmentioning

confidence: 99%

An overview of the physiopathology and various treatment strategies for polycystic ovary syndrome

Rajabi,

Babaie,

Sadeghzadeh Oskouei

et al. 2023

Reproductive and Developmental Medicine

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Polycystic ovary syndrome (PCOS), a common endocrine disorder with metabolic and reproductive consequences, affects a significant percentage of women of reproductive age. Because of its complexity and impact on the quality of life, PCOS requires timely diagnosis and screening for complications. The most common clinical manifestations of PCOS are hirsutism, hyperandrogenism, acne, irregular cycles, amenorrhea, and anovulation. Although PCOS has different clinical manifestations in women, hyperandrogenism, and anovulation are the most common symptoms. A good medical history, examination, blood tests, and ultrasound findings facilitate the diagnosis of PCOS. Novel treatments have also undergone clinical trials to improve the symptoms of PCOS. However, comprehensive review articles investigating the different communities of this disease are limited, and this review aimed to collect data on the different etiologies of PCOS along with the latest diagnostic methods and the most common and up-to-date treatments for this disease.

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Nutritional Management of Polycystic Ovary Syndrome: Insights into Diet and Nutrition Strategies

Jan,

Ahmad,

Ibrahim

et al. 2024

NRFHH

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Polycystic Ovary Syndrome (PCOS) is the primary endocrine disorder whose cause remains unidentified but is widely prevalent. This intricate condition affects a significant portion of women of reproductive age, affecting approximately 17.8% of them. While dietary approaches have been explored as the initial method of treatment for individuals with PCOS, there is no definitive consensus on the most effective diet. There is limited evidence to recommend a specific diet composition for PCOS with approaches including modifying protein, carbohydrate or fat quality or quantity generally having similar effects on the presentations of PCOS. It is crucial to recognize that maintaining a proper diet and ensuring sufficient nutritional status are pivotal factors in preventing the development of PCOS. In this comprehensive review, we explored various aspects of PCOS, ranging from its molecular pathogenesis to therapeutic dietary innovations and specific therapeutic interventions. Understanding the molecular pathogenesis of PCOS is vital, and we delve into the intricate mechanisms involved in its development. We examined the interplay between PCOS and metabolic conditions, such as insulin resistance and dyslipidemia, highlighting the interconnectedness of these aspects and their impact on the clinical presentation and management of the syndrome. While the optimal diet remains a subject of ongoing research, we emphasize on the critical role of proper diet and its potential in the avoidance and management of PCOS. Additionally, we reviewed specific dietary components, such as curcumin and green tea, and their potential therapeutic benefits in PCOS management.

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Inflammatory mediators in polycystic ovary syndrome: the case of interleukin-18

Cited by 3 publications

References 15 publications

Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment

Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment

An overview of the physiopathology and various treatment strategies for polycystic ovary syndrome

Nutritional Management of Polycystic Ovary Syndrome: Insights into Diet and Nutrition Strategies

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