Circulating IL-6, clusterin and irisin in obese subjects with different grades of obesity: association with insulin resistance and sexual dimorphism

Werida, Rehab H.; El-Gharbawy, Nashwa M.; Mostafa, Tarek Mohamed

doi:10.20945/2359-3997000000336

Cited by 6 publications

(3 citation statements)

References 44 publications

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“…Obesity is associated with immune responses that lead to a systemic low-grade proinflammatory state derived from an increase in adipocytes, loss of balance with immune cells, and the release of cytokines such as interleukin 6 (IL-6), which decreases adiponectin secretion [ 2 , 3 ]. In obesity, the IL-6 concentration increases, which decreases the sensitivity to insulin and increases glucose absorption in peripheral tissues [ 4 , 5 , 6 ], causing metabolic and cardiovascular diseases [ 7 ] and diabetes mellitus 2 [ 8 , 9 ]. Furthermore, adiponectin has been reported to increase adipocyte differentiation and inhibit IL-6 gene expression, which favors insulin sensitivity, preventing metabolic complications [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Food Consumption and Metabolic Risks in Young University Students

Gonzalez-Torres

González-Silva

Perez-Reyes

et al. 2021

IJERPH

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The purpose of this study was to analyze the association between components of the diet, metabolic risks, and the serum concentrations of adiponectin and interleukin-6 (IL-6). With prior informed consent, an analytical cross-sectional study was carried out with 72 students in their first year of university. The subjects had a mean age of 19.2 ± 1.0 years and body mass index of 23.38 ± 4.2, and they were mainly women (80.6%). Sociodemographic, anthropometric, and dietary data and metabolic risk factors were evaluated, and biochemical parameters and adipocytokines were also considered. The data were analyzed using means, ranges, and correlations, as well as principal components. In general, the protein, fat, and sodium intake were higher than the international dietary recommendations, and deficiencies in vitamins B5 and E, potassium, phosphorus, selenium, and zinc were observed. The most frequently observed metabolic risks were insulin resistance and hypoalphalipoproteinemia. IL-6 was positively correlated with lipid and protein intake. Adiponectin showed a positive correlation with high-density lipoprotein and a negative correlation with insulin, weight, and waist, while the adiponectin pattern was similar to that of vitamins E and A, which decreased with increasing intake of calories, macronutrients, and sodium. In general, a hypercaloric diet that was high in protein, fat, and sodium and deficient in vitamins, mainly fat-soluble, was associated with a lower concentration of adiponectin and a higher concentration of IL-6, which favor the presence of metabolic risks, including insulin resistance. Intervention studies are required to evaluate the dietary intake of metabolic markers in young people without comorbidities, which will lay the foundation for implementing prevention strategies.

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Section: Introductionmentioning

confidence: 99%

Food Consumption and Metabolic Risks in Young University Students

Gonzalez-Torres

González-Silva

Perez-Reyes

et al. 2021

IJERPH

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“…Serum levels of these cytokines are raised in obese individuals and those with chronic inflammatory conditions and abnormal serum lipid concentrations ( Panee, 2012 ; Sindhu et al, 2015 ; El-Mikkawy et al, 2020 ), which aligns with the changes in the biochemical profile observed in our study (shown in Table 2 ). Additionally, IL-6 adversely impacts lipid metabolism by increasing triglyceride release and reducing lipoprotein lipase activity ( Werida et al, 2021 ). Interestingly, we found an increase in the circulating levels of TNF-α in the HD groups at 6 and 13 months of age; however, those levels decreased at 13 months of age.…”

Section: Discussionmentioning

confidence: 99%

Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar rats

Salas-Venegas

Santín-Márquez

Ramírez-Carreto

et al. 2023

Front. Aging Neurosci.

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Being overweight and obesity are world health problems, with a higher prevalence in women, defined as abnormal or excessive fat accumulation that increases the risk of chronic diseases. Excess energy leads to adipose expansion, generating hypertrophic adipocytes that produce various pro-inflammatory molecules. These molecules cause chronic low-intensity inflammation, affecting the organism’s functioning and the central nervous system (CNS), inducing neuroinflammation. The neuroinflammatory response during obesity occurs in different structures of the CNS involved in memory and learning, such as the cortex and the hippocampus. Here we analyzed how obesity-related peripheral inflammation can affect CNS physiology, generating neuroinflammation and promoting cellular senescence establishment. Since some studies have shown an increase in senescent cells during aging, obesity, and neurodegenerative diseases, we proposed that cellular senescence participation may contribute to the cognitive decline in an obesity model of middle-aged female Wistar rats. The inflammatory state of 6 and 13 months-old female Wistar rats fed with a hypercaloric diet was measured in serum and CNS (cortex and hippocampus). Memory was evaluated using the novel object recognition (NOR) test; the presence of senescent markers was also determined. Our data suggest that the systemic inflammation generated by obesity induces a neuroinflammatory state in regions involved in learning and memory, with an increase in senescent markers, thus proposing senescence as a potential participant in the negative consequences of obesity in cognition.

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“…In addition, CLU levels are inversely correlated with cognitive function, glycosylated hemoglobin, and HOMA-IR but positively correlated with fasting C-peptide, suggesting that plasma CLU may be a potential marker for predicting metabolic disorders and cognitive disorders. Another study on the relationship between serum CLU and obese people without DM has found that in both men and women, CLU is signi cantly elevated in obese individuals, especially men, and is correlated with HOMA-IR, BMI, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), which are positively and negatively correlated with high-density lipoprotein cholesterol (HDL-C), indicating that CLU may be the insulin-like component of obese individuals and a potential therapeutic target for resistance [20] .…”

Section: Introductionmentioning

confidence: 99%

Serum glypican-4 and clusterin are increased and associated with insulin resistance in patients with polycystic ovary syndrome

Zheng

Zeng

Huang

et al. 2023

Preprint

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Objective: To investigate the changes in serum glypican-4 (GPC4) and clusterin (CLU) levels in patients with polycystic ovary syndrome (PCOS) as well as their correlation with sex hormones and metabolic parameters. Method: A total of 40 PCOS patients and 40 age-matched healthy women during the same period were selected. To detect and compare serum GPC4 and CLU levels between the two groups, binary logistic regression was used to analyze the relative risk of PCOS at different levels of serum GPC4 and CLU. Stepwise linear regression was used to analyze the influential factors of serum GPC4 and CLU in PCOS patients. Results: Serum GPC4 (1.82 ± 0.49 vs. 1.30 ± 0.61 ng/ml, P < 0.001) and CLU (468.79 ± 92.85 vs. 228.59 ± 82.42 µg/ml, P < 0.001) in PCOS patients were significantly higher than those in healthy women. In the PCOS group, serum GPC4 was positively correlated with FSH, FPG, FINS, HOMA-IR, TG, and CLU (P < 0.05), whereas serum CLU was positively correlated with BMI, FPG, FINS, and HOMA-IR (P < 0.05), multiple stepwise linear regression analysis showed that HOMA-IR was independently associated with serum GPC4, and it showed that BMI and HOMA-IR were independently associated with CLU (P < 0.05). Conclusion: Serum GPC4 and CLU levels in PCOS patients were significantly higher than those in healthy women, suggesting that GPC4 and CLU may be markers associated with insulin resistance in women with PCOS.

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Circulating IL-6, clusterin and irisin in obese subjects with different grades of obesity: association with insulin resistance and sexual dimorphism

Cited by 6 publications

References 44 publications

Food Consumption and Metabolic Risks in Young University Students

Food Consumption and Metabolic Risks in Young University Students

Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar rats

Serum glypican-4 and clusterin are increased and associated with insulin resistance in patients with polycystic ovary syndrome

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