COVID-19 and obesity: the meeting of two pandemics

Brandão, Simone Cristina Soares; Godoi, Emmanuelle Tenório Albuquerque Madruga; Cordeiro, Lúcia Helena de Oliveira; Bezerra, Camila; Ramos, Júlia de Oliveira Xavier; Arruda, Gustavo Freitas Alves de; Lins, Esdras Marques

doi:10.20945/2359-3997000000318

Cited by 10 publications

(8 citation statements)

References 82 publications

(113 reference statements)

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“…This change in profile may result from improved reporting, with a consequent decrease in missing data. Perhaps scientific evidence indicating the importance of these comorbidities in influencing the severe form of COVID-19 ( 42 - 43 ) encouraged improved reporting.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with death among postpartum women with COVID-19: a Brazilian population-based study

Bonatti

Miller

Carvalhães

et al. 2021

Rev. Latino-Am. Enfermagem

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Objective: to identify the factors associated with death due to COVID-19 among Brazilian postpartum women in the first five months of the pandemic and five subsequent months, and describe the sociodemographic and clinical characteristics of postpartum women who developed the disease. Method: cross-sectional population-based study using a secondary database available in the Sistema de Informação de Vigilância Epidemiológica da Gripe -SIVEP-Gripe (Influenza Epidemiological Surveillance Information System), Brazilian Ministry of Health. A total of 869 postpartum women were included, and the analysis considered the first five months of the pandemic and subsequent five months. Association between the variables of interest and outcome (death due to COVID-19/cure) was investigated using logistic regression. Results: most participants were aged between 20 and 34, of mixed race or Caucasian, and lived in the urban/peri-urban area. The proportion of deaths was 20.2% in the first period and 11.2% in the second. The likelihood of death increased in both periods due to the presence of respiratory signs and symptoms: dyspnea, respiratory distress, and oxygen saturation below 95%, in addition to the need for ventilatory support and intensive care. Conclusion: the proportion of deaths among postpartum women was high and decreased in the second period under study. Respiratory signs and symptoms, mechanical ventilation, and intensive care were associated with death in both periods.

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Section: Discussionmentioning

confidence: 99%

Factors associated with death among postpartum women with COVID-19: a Brazilian population-based study

Bonatti

Miller

Carvalhães

et al. 2021

Rev. Latino-Am. Enfermagem

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“…38 Immune dysregulation, which tends to occur in obese individuals affected by COVID-19, may be related to a phenomenon known as hypercytokinemia or "cytokine storm. " 39 However, Brandão et al 40 have indicated that the initial immune response is very weak considering the high SARS-CoV-2 viral load, which justifies the excessive recruitment of cytokines. This mechanism of action is aggravated by viral overload in epithelial cells, especially in the lungs, causing the collapse of these structures.…”

Section: Obesity and Covid-19mentioning

confidence: 99%

Molecular aspects of COVID-19 and its relationship with obesity and physical activity: a narrative review

et al. 2023

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BACKGROUND: Severe acute respiratory syndrome coronavirus 2 has several mechanisms of action related to inflammatory responses, especially in individuals diagnosed with obesity. This hyperinflammatory clinical profile resulting from the association between obesity and coronavirus disease 2019 (COVID-19) may be attenuated by regular physical activity. OBJECTIVE: The aim of this study was to review the evidence on the consequences of physical inactivity and physical activity on COVID-19 in patients with obesity. DESIGN AND SETTING: Narrative review at the Bahiana School of Medicine and Public Health in Salvador, Brazil. METHODS: We searched evidence on the association of COVID-19 with physical activity and obesity using the following keywords: "covid-19, " "physical activity, " and "obesity". The databases used were MEDLINE (PubMed), ScienceDirect, and Virtual Health Library. Studies published from 2019 to 2021 and available in Portuguese, English, and Spanish were included. The final search was conducted on September 26, 2021. RESULTS: We identified 661 studies in the database, among which 71 were considered for inclusion in the narrative review of the molecular aspects of COVID-19 and its relationship with physical activity and obesity. CONCLUSION: This literature review enabled the perception of the relationship between the molecular mechanisms of COVID-19 and obesity. Regular physical activity had various benefits for the inflammatory condition of the studied population, highlighting moderate-intensity..

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“…Adipose tissue is also a target and reservoir of SARS-CoV-2 [69,70]. The increased risk of severe COVID-19 in "Obesity" is well established [71][72][73][74][75]; the risks are higher for hospitalization and death [73,76,77]. The risk was estimated to be three-fold higher than normal-weight individuals [78].…”

Section: Metabolic Abnormalitiesmentioning

confidence: 99%

Polycystic ovary syndrome and risks for COVID-19 infection: A comprehensive review

Medeiros

Yamamoto

Medeiros

et al. 2022

Rev Endocr Metab Disord

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This comprehensive review aimed to evaluate the relationship between SARS-CoV-2 infection (the cause of coronavirus disease 2019, or COVID-19) and the metabolic and endocrine characteristics frequently found in women with polycystic ovary syndrome (PCOS). In the general population, COVID-19 is more severe in subjects with dyslipidemia, obesity, diabetes mellitus, and arterial hypertension. Because these conditions are comorbidities commonly associated with PCOS, it was hypothesized that women with PCOS would be at higher risk for acquiring COVID-19 and developing more severe clinical presentations. This hypothesis was confirmed in several epidemiological studies. The present review shows that women with PCOS are at 28%–50% higher risk of being infected with the SARS-CoV-2 virus at all ages and that, in these women, COVID-19 is associated with increased rates of hospitalization, morbidity, and mortality. We summarize the mechanisms of the higher risk of COVID-19 infection in women with PCOS, particularly in those with carbohydrate and lipid abnormal metabolism, hyperandrogenism, and central obesity.

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COVID-19 and obesity: the meeting of two pandemics

Cited by 10 publications

References 82 publications

Factors associated with death among postpartum women with COVID-19: a Brazilian population-based study

Factors associated with death among postpartum women with COVID-19: a Brazilian population-based study

Molecular aspects of COVID-19 and its relationship with obesity and physical activity: a narrative review

Polycystic ovary syndrome and risks for COVID-19 infection: A comprehensive review

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