Association between T2DM and the lowering of testosterone levels among Kashmiri males

Farooq, Rabia; Bhat, Mohd Shafi; Majid, Sabhiya; Mir, Mohammad Muzaffar

doi:10.20945/2359-3997000000288

Cited by 3 publications

(6 citation statements)

References 33 publications

(39 reference statements)

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“…In the present study, we observed negative association of serum testosterone levels with blood glucose markers including HbA1c values, which is in consistent with the studies of Fukui et al [22], Rabia et al [29], and Laaksonen et al [30] where serum testosterone levels were shown to have negative association with glucose markers, Not only HbA1c levels but Insulin resistance indicators as BMI, waist/hip ratio and waist/height ratio among males have also been found to be related with lower levels of testosterone levels. Many such studies have confirmed that insulin resistance is found to be associated with low serum testosterone levels.…”

Section: Discussionsupporting

confidence: 93%

Prevalance and Risk Factors of Hypogonadism in Male Patients with Type 2 Diabetes in El Minya, Egypt

2023

Endocrinol Diabetes Metab J

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Background: Hypogonadism in adult men is a clinical and biochemical syndrome associated with low level of testosterone, which may adversely affect multiple organ functions and quality of life. It is closely related to the development of diabetes. This study was designed to determine the incidence of hypogonadism and related risk factors among men with type 2 diabetes (T2D).Patients and Methods: A total of 300 male patients diagnosed with T2D age from 30-70 years were enrolled in the study. Arabic version of the Androgen Deficiency in Aging Male (ADAM) questionnaire was employed to assess the androgen insufficiency in men. Hemoglobin A1c, FSH, LH, total and free testosterone, levels were measured by enzyme immunoassay.Results: T2D patients were divided into two groups: 48 (16%) patients with hypogonadism and 252 (84%) patients without hypogonadism. Multiple logistic regression analysis for factors affecting Hypogonadism among patients according to (total testosterone + ADAM +ve) versus those without hypogonadism it was found that age, random blood sugar, body mass index (BMI), Hb A1c are independent risk factors for the development of hypogonadism with odds ratio (0.95, 1, 1.1, 1.37) with p value (0.02, 0.03, 0. 03, 0.008) respectively. The ROC analysis of the accuracy of indices and cut off values for the studied total testosterone for predicting the hypogonadism according to total testosterone + ADAM score positive: The AUC was 0.98 «p-value <0.0001» with sensitivity 100% and specificity of 96.4% at Cut off value ≤ 12. Conclusion:Several risk factors of diabetes are associated closely with hypogonadism. Age, BMI, blood sugar, and Hb A1c are independent risk factors for the development of hypogonadism in male patients with T2D. Patients and MethodsThis prospective cross sectional study included a total of 300 T2D patients; all patients gave verbal consent to participate in the study. Patients were selected from those coming for follow up at different Minia University and Ministry of Health hospitals in the period between January 2018 and June 2019. Patients are known to have type 2 diabetes mellitus according to criteria of American diabetic association [6].

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Section: Discussionsupporting

confidence: 93%

Prevalance and Risk Factors of Hypogonadism in Male Patients with Type 2 Diabetes in El Minya, Egypt

2023

Endocrinol Diabetes Metab J

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“…We found negative correlation of testosterone with FBG, RBG and A1C. Our findings are in correlation consistent with previous studies [10][11][12][13][14]. Previous studies 10,11 found similar results of negative correlation of FBG and RBG with testosterone (shown in table -1).…”

Section: Discussionsupporting

confidence: 92%

“…Similar finding of negative linear correlation of testosterone with cholesterol, TAGs, HDLc and positive correlation with LDLc was reported by a previous study [11]. Of 100 male types 2 diabetics, 46% cases exhibited low testosterone in present study the finding is agreed by previous studies [7,[11][12]. Previous studies found low testosterone in 44.5% and 42% respectively [11][12].…”

Section: Discussionsupporting

confidence: 92%

“…Of 100 male types 2 diabetics, 46% cases exhibited low testosterone in present study the finding is agreed by previous studies [7,[11][12]. Previous studies found low testosterone in 44.5% and 42% respectively [11][12]. A previous study studied 83 type 2 diabetics and found low testosterone in 44.58% of male diabetics [12].…”

Section: Discussionsupporting

confidence: 92%

“…A previous study found negative correlation of testosterone with cholesterol (r=-0.142, P=0.002), triglycerides (r=-0.097, P=0.040) in male diabetics similar to present study [13]. Similar finding of negative linear correlation of testosterone with cholesterol, TAGs, HDLc and positive correlation with LDLc was reported by a previous study [11]. Of 100 male types 2 diabetics, 46% cases exhibited low testosterone in present study the finding is agreed by previous studies [7,[11][12].…”

Section: Discussionsupporting

confidence: 91%

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Testosterone Correlation with Low and High Density Lipoprotein in Male Type 2 Diabetics

Laghari

Murtaza

Talpur

et al. 2021

JPRI

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Aim: To determine correlation of serum testosterone with low and high density lipoprotein in male type 2 Diabetics presenting at a tertiary care hospital of Sindh. Methodology: A cross sectional study, Department of Biochemistry and Department of Medicine, Liaquat University Hospital from January 2018 to February 2019. One hundred male type 2 diabetics (cases) and one hundred age matched male (control) were selected through non – probability purposive sampling. Male diagnosed cases of DM belonging to 4th to 6th decade of life was included. Blood samples were collected by venesection and sera were squeezed by centrifugation and stored at – 20 0C in refrigerators. Testosterone was estimated by the ELISA (competitive immuno- assay) assay method and blood lipids - cholesterol, triglycerides (TAGs), LDLc and HDLc by colorimetric method. Pearson`s correlation was generated on Statistical software SPSS 21.0 version (IBM, Incorp, USA) for correlation of serum testosterone with lipids fractions (P≤0.05). Results: Age shows majority of male type 2 diabetics were in their 5th decade. We found low serum testosterone level (10.85±4.7 mmol/L) in cases compared to normal testosterone level (13.39±3.8 mmol/L) in control (P=0.0001). Pearson`s correlation shows inverse association with HDLc (r= -0.70) (P=0.0001) and positive association with LDLc (r= 0.670) (P=0.0001). Conclusion: We found low serum testosterone in male type 2 diabetics that showed negative correlation with high density lipoprotein (HDLc) and positive correlation with low density lipoprotein (LDLc).

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Hypogonadism among Type 2 Diabetes Mellitus Patients with Male Erectile Dysfunction

Kadhim,

Almomin,

Mansour

2023

Ibnosina Journal of Medicine and Biomedical Sciences

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Introduction Testosterone levels and erectile function are known to decline as men age, leading to hypogonadism and erectile failure. Men with type 2 diabetes mellitus (T2DM) have a high prevalence of hypogonadism and erectile dysfunction. We aimed to estimate the prevalence of hypogonadism in T2DM patients complaining of erectile dysfunction. Patients and Methods A cross-sectional study was conducted at Specialized Diabetes, Endocrine, and Metabolism Center from early September 2021 to the end of January 2022. The study included 115 fully anonymized randomly selected patients. Patients with diabetes were assessed for erectile dysfunction through a questionnaire derived from “The International Index of Erectile Function (IIEF).” Additionally, hypogonadism has been diagnosed with serum testosterone levels lower than 264 mg/dL according to the Endocrine Society 2018 criteria for the diagnosis of male hypogonadism. Results The average duration of diabetes was 6.2 years, and the mean glycated hemoglobin value was 9.3%. Dyslipidemia was the most prevalent chronic comorbid condition (84.3%) accompanying diabetes and erectile dysfunction, followed by hypertension (56.5%). An approximately similar rate of hypogonadism was observed in patients with diabetes and erectile dysfunction regardless of whether the other chronic disease was also present. From 115 patients included in this study, hypogonadism was diagnosed in 26% of patients with diabetes and erectile dysfunction. Conclusion A significant number of hypogonadisms occur in patients with diabetes and erectile dysfunction, which require particular emphasis

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Association between T2DM and the lowering of testosterone levels among Kashmiri males

Cited by 3 publications

References 33 publications

Prevalance and Risk Factors of Hypogonadism in Male Patients with Type 2 Diabetes in El Minya, Egypt

Prevalance and Risk Factors of Hypogonadism in Male Patients with Type 2 Diabetes in El Minya, Egypt

Testosterone Correlation with Low and High Density Lipoprotein in Male Type 2 Diabetics

Hypogonadism among Type 2 Diabetes Mellitus Patients with Male Erectile Dysfunction

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