Moderator role of vitamin D concentrations on the association between metabolic syndrome and C-reactive protein among adults

Abstract

Objective: To evaluate the association between MetS, its components and insulin resistance (IR) with 25(OH)D and hsCRP. The moderator role of 25(OH)D in the association of MetS, its diagnostic components and IR with hsCRP were also explored. Materials and methods: A cross-sectional study (2014/2015) with a population-based cohort in Southern Brazil (n = 605). Metabolic syndrome (MetS) diagnosis was defined based on the Joint Interim Statement, while the Homeostasis Model Assessment of insulin resistance (IR) (HOMA-IR) was used for determining IR. Serum concentrations of 25-hydroxy vitamin D [25(OH)D] (ng/mL) and high sensitivity C-reactive protein (hsCRP) (mg/L) were evaluated following standard protocols. 25(OH)D was categorized as sufficiency (>30 ng/mL), insufficiency (20-30 ng/mL) or deficiency (<20 ng/mL) to test its moderator role. Multiple linear regression was used to test the associations. The results were adjusted for possible confounders. Results and discussion: Hypertriglyceridemia and IR were associated with lower 25(OH)D concentrations. However, except for systolic blood pressure, other MetS components and IR were associated with higher hsCRP. The association between elevated waist circumference (WC) and hsCRP was moderated by the 25(OH) D concentrations. The hsCRP median concentrations were more than two times higher among those with elevated WC and 25(OH)D insufficiency or deficiency. In this study, inadequate concentrations of 25(OH)D increased the adverse relationship between elevated WC and inflammation. 25(OH) D concentrations could be incorporated into the clinical protocols for monitoring individuals with abdominal obesity to identify those at a higher risk of complications.

Counterfactual approach on the effect of metabolic syndrome on tooth loss: A population‐based study

“…When the difference between measurements was >20 mmHg for systolic blood pressure or >10 mmHg for diastolic blood pressure, a third measurement was performed to replace the highest value. The average blood pressure measurement was considered for analysis 19 . Waist circumference was measured in the narrowest part of the trunk using an inextensible anthropometric tape (Sanny, São Bernardo do Campo, Brazil).…”

“…Samples were stored and analyzed according to technical standards of the Laboratory of Clinical Analysis (University Hospital, Federal University of Santa Catarina). Fasting blood glucose and lipid profile (triglycerides and HDL) were determined by colorimetric tests 19 …”

“…The average blood pressure measurement was considered for analysis. 19 Waist circumference was measured in the narrowest part of the trunk using an inextensible anthropometric tape (Sanny, São Bernardo do Campo, Brazil). Blood samples were collected early in the morning after fasting for at least 8 hours.…”

“…Fasting blood glucose and lipid profile (triglycerides and HDL) were determined by colorimetric tests. 19…”

Serum and Dietary Vitamin D in Individuals with Class II and III Obesity: Prevalence and Association with Metabolic Syndrome

“…Adipose and metabolic tissue disorders in obese individuals contribute to metabolic syndrome (MS) [ 15 ] as well as to hypovitaminosis D [ 16 ]. Serum vitamin D levels are negatively correlated with MS’s parameters, such as abdominal obesity, insulin resistance, fasting blood glucose, arterial hypertension, and triglycerides [ 17 , 18 , 19 , 20 ]. In fact, the association between MS and vitamin D has been studied in several populations [ 21 , 22 , 23 ].…”