Central and peripheral blood pressures and arterial stiffness increase in hypoparathyroidism

Abstract

Objective:The aim of the present study was to evaluate whether arterial stiffness is affected in the patients with hypoparathyroidism through pulse wave analysis (PWA). Subjects and methods: Sixty-three patients diagnosed with hypoparathyroidism and sixty volunteers were evaluated for the study. When 21 patients were excluded in the hypoparathyroidism group due to exclusion criteria, the research continued with 42 patients and 60 volunteers who are similar to the patients in terms of age, gender and body mass index (BMI). Fasting plasma glucose after 10 hours of fasting, creatinine, thyroid stimulating hormone (TSH), free thyroxine (fT4), albumin, calcium, phosphorus, magnesium, 25-OH vitamin D, parathormone (PTH) and urine calcium results in 24-hour urine for the patients in the hypoparathyroidism group were recorded. Evaluation of arterial stiffness was performed by Mobil-O-Graph 24h PWA device. Results: Systolic blood pressure (SBP) (p = 0.01), diastolic blood pressure (DBP) (p = 0.005), mean blood pressure (p = 0.009), central SBP (p = 0.004), central DBP (p = 0.01) and pulse wave velocity (PWV) (p = 0.02) were found higher in the hypoparathyroidism group. A positive correlation was detected between phosphorus level and SBP [(p = 0.03. r = 0.327)], central SBP [(p = 0.04, r = 0.324)] and PWV [(p = 0.003, r = 0.449)]. We detected that age and serum phosphorus levels were independent predictor variables for PWV (B = 0.014, p < 0.001 and B = 0.035, p < 0.001, respectively). Conclusion: We detected that hypoparathyroidism causes an increase in blood pressure and arterial stiffness. The most significant determinant factors were detected as advanced age and hyperphosphatemia. The patients diagnosed with hypoparathyroidism should be closely monitored and treatment planning should include to prevent the patients from hyperphosphatemia.

The Effect of High Polyphenol Extra Virgin Olive Oil on Blood Pressure and Arterial Stiffness in Healthy Australian Adults: A Randomized, Controlled, Cross-Over Study

“…Further to dietary energy intake, our study also recorded the intake of macro-(i.e., protein and dietary fibre) and micronutrients (i.e., sodium, potassium, magnesium and calcium) that have established effects on BP levels [39][40][41][42]. In this regard, there were no differences between the two intervention arms, indicating that the only dietary factor which could account for the observed favourable effect to reduce SBP, was the higher phenolic content in HPOO compared to LPOO.…”

Arterial Stiffness in Thyroid and Parathyroid Disease: A Review of Clinical Studies

“…Interestingly, hypoparathyroidism has also been associated with an increase of arterial stiffness [ 81 , 82 ], consistent with the higher risk of cardiovascular disease of patients affected by this condition.…”

Evaluating the Arterial Stiffness as a Useful Tool in the Management of Obese Children

“…In the control group, significant positive correlations were detected with the same markers, except for PWV. Most studies on adults linking iCa levels to arterial stiffness refer to patients with hypoparathyroidism, in which case low iCa is associated with high PWV; or to patients with chronic kidney disease which is often associated to secondary hyperparathyroidsm, in which case high phosphorus and low iCa correlates with high PWV and BP levels [105]. In patients undergoing haemodialysis, high iCa is correlated to high PWV [106].…”