Comparison between peak systolic velocity of the inferior thyroid artery and technetium-99m pertechnetate thyroid uptake in differentiating Graves’ disease from thyroiditis

Malik, Sajad Ahmad; Choh, Naseer A.; Misgar, Raiz Ahmad; Khan, Shoukat H; Shah, Zaffar Amin; Rather, Tanveer Ahmad; Shehjar, Faheem; Laway, Bashir Ahmad

doi:10.20945/2359-3997000000165

Cited by 5 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Further by ROC analysis, we obtained a similar mean PSV in ITA cutoff value of 29.5 cm/sec, at a sensitivity of 91.8% and specificity of 90.9%. A study by Malik et al [ 8 ] showed that measurement of PSV-ITA by CFDU is a good diagnostic approach to discriminate between GD and thyroiditis with a sensitivity of 91% and specificity of 89% to differentiate between the two conditions at a cutoff level of 30 cm/s, which was similar to that obtained in our study. Our results are also in agreement with those of Kurita and cols.…”

Section: Discussionsupporting

confidence: 90%

“…We used the Chi-square test for categorical data and the independent samples Student's t test for parametric quantitative data. Based on previous literature a T3/T4 ratio (ng/μg) cutoff of more than 20,[ 3 ] an FT3/FT4 ratio more than 0.3[ 7 ] and a mean PSV-ITA of more than 30 cm/s[ 8 ] were considered as suggestive of GD. In addition, we did an ROC curve analysis to derive cutoffs.…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

See 1 more Smart Citation

Rapid differential diagnosis of thyrotoxicosis using T3/T4 ratio, FT3/FT4 ratio and color doppler of thyroid gland

Narkar¹,

Mishra²,

Choudhury³

2021

Indian J Endocr Metab

View full text Add to dashboard Cite

Context: Establishing the etiology of thyrotoxicosis is of utmost importance to plan the appropriate line of therapy. However, certain scenarios such as absence of pathognomonic clinical features of Graves’ disease in some patients, or non-availability of radionuclide scanning and newer generation TRAb assays especially in resource-poor settings, necessitates utilization of other, simple and effective measures to differentiate between the two common causes of thyrotoxicosis, Graves’ disease (GD) and Destructive thyroiditis (DT). Aims: The aim of this work was to study the role of FT3/FT4 ratio, T3/T4 ratio and color flow Doppler ultrasound in treatment-naïve patients with thyrotoxicosis, in comparison to Tc-99m pertechnetate thyroid scanning in the differentiation of thyrotoxicosis due to GD and DT. Materials and Methods: Clinical data was collected from all study subjects. Thyroid function tests including FT3, FT4, T3, T4 and TSH, TSH Receptor Antibody (TRAb), Technetium Tc 99m pertechnetate scan and the mean peak systolic velocity in inferior thyroid artery (mean PSV-ITA) by color Doppler ultrasonography of thyroid gland was done in all patients. Results: A total of 83 treatment-naïve patients with thyrotoxicosis (61 with GD and 22 with DT) were studied. Mean PSV-ITA, T3/T4 ratio and FT3/FT4 ratio showed a sensitivity of 85.2%, 73.8%, and 77.04%, and a specificity of 90.9%, 72.7%, and 59.09%, respectively. The three parameters in combination yielded a positive predictive value of 100% in the diagnosis of Graves’ disease. Conclusion: Results of this study show that inferior thyroid artery blood flow, T3/T4 ratio and FT3/FT4 ratio are useful parameters in the differentiation between GD and DT.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Aterials and M Ethodsmentioning

confidence: 99%

Rapid differential diagnosis of thyrotoxicosis using T3/T4 ratio, FT3/FT4 ratio and color doppler of thyroid gland

Narkar¹,

Mishra²,

Choudhury³

2021

Indian J Endocr Metab

View full text Add to dashboard Cite

show abstract

“…The study by Malik et al 43 also showed that 99m TC pertechnetate scanning exhibited a similar specificity and a positive predictive value (PPV) as ITA-PSV in differentiating between Graves’ disease and thyroiditis, although a greater sensitivity was encountered with scintigraphy (100% versus 91%, respectively). However, the latter study and a former study by Smith and Oates 46 observed that some patients with resolving thyroiditis can display increased uptake on nuclear scanning that may be indicative of Graves’ disease and this can be potentially confusing.…”

Section: Discussionmentioning

confidence: 90%

“…Another study identified a mean ITA-PSV cut-off value of 30 cm/s for differentiating between Graves’ disease and thyroiditis with a sensitivity of 91% and a specificity of 89% on ROC curve analysis. 43 …”

Section: Discussionmentioning

confidence: 99%

Duplex Hemodynamic Parameters of Both Superior and Inferior Thyroid Arteries in Evaluation of Thyroid Hyperfunction Disorders

Hussein¹,

Hamid²,

Samie³

et al. 2022

IJGM

View full text Add to dashboard Cite

Background Thyrotoxicosis may be caused by Graves’ disease or destructive thyroiditis. Differentiation between causes of thyrotoxicosis is crucial as management will differ. 99m Technetium (Tc)-pertechnetate thyroid scintigraphy is currently the gold standard for this purpose, however, is expensive and uses ionizing radiation. Objective To evaluate the role of color flow Doppler Ultrasound (CDU) of the superior thyroid (STA) and inferior thyroid arteries (ITA) as an inexpensive, non-invasive tool that can aid in differentiating between Graves’ disease and thyroiditis and compare it with thyroid scintigraphy. Methods Sixty-nine patients with newly-diagnosed thyrotoxicosis and 30 controls were enrolled. Thyroid functions, thyroid scintigraphy, and CDU of STA and ITA with measurements of peak systolic velocity (PSV) and end diastolic velocity (EDV), were performed. According to thyroid scintigraphy results, patients were divided into two groups: 42 patients with Graves’ disease and 27 patients with thyroiditis. Results PSV and EDV of both STA and ITA were significantly higher in patients with Graves’ disease than thyroiditis ( p -values <0.001). The STA-PSV had an equal sensitivity and specificity of 66.7%; cut-off value 76.57 cm/s, while those of STA-EDV were 73.8%, and 77.8% respectively; cut-off value 28.22 cm/s. ITA-PSV had a sensitivity and specificity of 76.2% and 77.8%, respectively; cut-off value 62.12 cm/s), while those of ITA-EDV were 78.6% and 77.8%, respectively; cut-off value 5.22 cm/s. Conclusion CDU parameters of the STA and ITA could be used as an alternative to thyroid scintigraphy for discriminating between Graves’ disease and thyroiditis.

show abstract

“…La gammagrafía de tiroides es considerada por algunos autores como la prueba de referencia en imágenes para el diagnóstico diferencial de la etiología del hipertiroidismo. Malik, et al ., encontraron una sensibilidad de la captación de tecnecio-99 del 100 %, igual a la sensibilidad de los TRAbs, y una especificidad de 84 % Vs. 89 % 27 . Los datos del presente estudio son similares a los de Perdomo, et al ., quienes no encontraron captación, o solo baja en el 19 %, e hipercaptación, en el 80,5 % de los pacientes con tirotoxicosis 28 .…”

Section: Discussionunclassified

Hipertiroidismo en niños y adolescentes: experiencia en un hospital universitario en Colombia

et al. 2022

View full text Add to dashboard Cite

Introducción. El hipertiroidismo es una condición heterogénea caracterizada por la producción excesiva de hormonas tiroideas. Su aparición en la edad pediátrica representa un reto diagnóstico y terapéutico.Objetivo. Describir las características clínicas y paraclínicas, así como la evolución y las diferencias entre las principales causas etiológicas de los pacientes con hipertiroidismo atendidos por el Servicio de Endocrinología Pediátrica del Hospital Universitario San Vicente Fundación en Medellín, Colombia, entre el 1° de julio de 2015 y el 30 de junio de 2020. Materiales y métodos. Se hizo un estudio observacional transversal con recolección retrospectiva de la información.Resultados. Se incluyeron 54 pacientes con una edad media de 11,9 años, 72,2 % de ellos mujeres. El 11,1 % tenía antecedentes familiares de enfermedad de Graves y 29,6 % de otras enfermedades tiroideas. El bocio fue la manifestación clínica más frecuente (83,3 %). El 92,6 % había recibido terapia con metimazol, el 79,6 % requirió betabloqueador y el 11,2 % necesitó una terapia farmacológica adicional. Se presentaron reacciones adversas a la medicación en el 16,7 %. En el 20,4 % de los pacientes hubo resolución del hipertiroidismo (espontánea: 9,3 %; posterior a la ablación con yodo radiactivo: 9,3 %, y después de la cirugía: 1,9 %).Conclusión. El hipertiroidismo es una enfermedad con manifestaciones clínicas diversas. La causa más frecuente es la enfermedad de Graves, seguida por la hashitoxicosis. En este estudio, la hashitoxicosis fue más frecuente que en estudios previos. La duración y los efectos secundarios del tratamiento farmacológico fueron similares a los reportados previamente, pero es de resaltar la mayor frecuencia de agranulocitosis en nuestra población.

show abstract

Comparison between peak systolic velocity of the inferior thyroid artery and technetium-99m pertechnetate thyroid uptake in differentiating Graves’ disease from thyroiditis

Cited by 5 publications

References 24 publications

Rapid differential diagnosis of thyrotoxicosis using T3/T4 ratio, FT3/FT4 ratio and color doppler of thyroid gland

Rapid differential diagnosis of thyrotoxicosis using T3/T4 ratio, FT3/FT4 ratio and color doppler of thyroid gland

Duplex Hemodynamic Parameters of Both Superior and Inferior Thyroid Arteries in Evaluation of Thyroid Hyperfunction Disorders

Hipertiroidismo en niños y adolescentes: experiencia en un hospital universitario en Colombia

Contact Info

Product

Resources

About