Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy

Campos, Raquel Munhoz da Silveira; Masquio, Deborah Cristina Landi; Corgosinho, Flávia Campos; Ferreira, Juliana; Netto, Bárbara Dal Molin; Clemente, Ana Paula Grotti; Tock, Lian; Tufik, Sérgio; Mello, Marco Túlio de; Dâmaso, Ana Raimunda

doi:10.20945/2359-3997000000039

Cited by 16 publications

(11 citation statements)

References 41 publications

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“…Thus, we believe that serum adipokine concentrations in the present study were not problematic, as these were below the values obtained in other studies with obese adolescents (27,53) . In addition, the fact that adipokine concentrations remain similar after interdisciplinary intervention suggests that other factors, besides fat percentage and BMI (53,55,56) , may be involved in the expression of adiponectin and leptin, such as sexual maturation (57) .…”

Section: -Month Interdisciplinary Interventioncontrasting

confidence: 83%

“…These findings corroborate a randomised clinical trial with children and adolescents between 8 and 17 years of age who displayed a reduction in BMI after a low-energy diet followed by lung function improvement without alteration in inflammatory markers (52) . In a similar study, leptin of obese adolescents also did not present a significant change after intervention (53) . These results differ from a previous study conducted by our group (27) , which showed that an interdisciplinary intervention reduced serum leptin concentrations and increased adiponectin in obese adolescents, regardless of asthma diagnosis.…”

Section: Discussionmentioning

confidence: 74%

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Nutrient intake is a predictor of lung function in obese asthmatic adolescents undergoing interdisciplinary therapy

et al. 2019

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Asthma-obesity is a multifactorial disease with specific asthma phenotypes that aggravate due to overweight and an unbalanced diet. Furthermore, obese asthmatic patients are corticotherapy-resistant. Therefore, the aims of the present study were to evaluate the effects of an interdisciplinary intervention on food consumption, body composition, lung function and adipokines in asthmatic and non-asthmatic obese adolescents and to investigate the influence of nutrients on lung function. Obese non-asthmatic (n 42) and obese asthmatic (n 21) adolescents of both sexes were enrolled in the present study. Food intake, adipokine levels, body composition, asthma symptoms and lung function were assessed across the study. After the intervention of 1 year, there was a reduction (P ≤ 0·01) in BMI, body fat percentage, visceral and subcutaneous fat and an increase (P ≤ 0·01) in lean mass and all lung function variables in both groups, except the relation between forced expiratory volume in 1 s and forced vital capacity (FEV1:FVC) in non-asthmatic patients. Moreover, both groups decreased lipid and cholesterol consumption (P ≤ 0·01). The highest energy consumption (β = −0·021) was associated with lower values of FVC. Similarly, carbohydrate consumption (β = −0·06) and cholesterol were negative predictors (β = −0·05) in FEV1:FVC. However, the consumption of Ca (β = 0·01), fibres (β = 1·34) and vitamin A (β = 0·01) were positive predictors of FEV1:FVC. Asthma-obesity interdisciplinary treatment promoted an improvement on food consumption and lung function in adolescents and demonstrated that the consumption of nutrients influenced an increase in lung function.

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Section: -Month Interdisciplinary Interventioncontrasting

confidence: 83%

Section: Discussionmentioning

confidence: 74%

Nutrient intake is a predictor of lung function in obese asthmatic adolescents undergoing interdisciplinary therapy

et al. 2019

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“…Campos and cols. have analyzed clinical, laboratory and anthropometric and body composition parameters in a cohort of 34 obese adolescents submitted to a one-year interdisciplinary intervention including exercise, diet and psychological support (7). As expected, the intervention resulted in a reduction in body mass and fat was seen, accompanied by a significant increase in adiponectin and in lean mass.…”

mentioning

confidence: 82%

The elusive clinical significance of osteocalcin actions in energy metabolism in humans

Ferraz-de-Souza¹

2018

Archives of Endocrinology and Metabolism

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I n spite of its stagnant gross appearance, the skeleton is a highly metabolically active organ. The continuous process of bone remodeling, allowing homeostatic availability of calcium and renovation of the important structural material of bone, requires ample energy supply (1). Extreme examples of such energy demand had been noticed a long time ago in high bone turnover states, for instance in the cachexia accompanying severe hyperparathyroidism or in slender children with osteogenesis imperfecta, but lacked an explanation. Therefore, when the first mechanistic pieces of evidence linking bone and energy metabolism in animal models started arising (2), it not only made sense in physiological terms, but it was also felt as if by identifying these missing links we would potentially be able to tackle simultaneously two major health care concerns, adiposity and osteoporosis.It has now been more than 10 years since the paramount work of Lee and cols. placed osteocalcin (Oc) as the foremost bone-derived hormone to influence energy metabolism (3), rocketing Oc from its role as a (perhaps second rate) bone formation marker to a means by which bone, as an endocrine gland, would direct insulin sensitivity and production, and fat accumulation. From then onwards, subsequent evidence have solidified that, in mice, Oc favors glucose tolerance and insulin sensitivity (4,5). Its role as an energy metabolism effector in humans, however, remains elusive.Osteocalcin is produced by osteoblasts and secreted in a fully carboxylated form into the bone matrix, where it acts to regulate bone mineralization. Under acidic pH in the osteclastic resorption lacuna, it suffers decarboxylation generating undercarboxylated Oc -importantly, this is the form of Oc that has been chiefly linked to a metabolic role, but its determination in serum is not straightforward in clinical or even in research settings (5). Several studies in humans have investigated the relationship of total serum Oc and a variety of metabolic parameters, and results have been conflicting (6). Indeed, an effect, when seen, was considerably smaller in magnitude to what was observed in mice.Two articles in this issue of the Archives of Endocrinology and Metabolism (AE&M) have aimed to shed light on this topic through different approaches. Campos and cols. have analyzed clinical, laboratory and anthropometric and body composition parameters in a cohort of 34 obese adolescents submitted to a one-year interdisciplinary intervention including exercise, diet and psychological support (7). As expected, the intervention resulted in a reduction in body mass and fat was seen, accompanied by a significant increase in adiponectin and in lean mass. Even though an increase in bone mineral content was observed after the 1-year intervention, the expected progression of bone accretion during this period of life precludes ascertaining a positive effect of exercise on bone formation. The authors focused their analysis on the relation

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“…Adiponectin and leptin, which are produced by adipose tissues, exert some effects on osteoblasts and osteoclasts (Tamura et al, 2007; Williams et al, 2009). A positive correlation was shown between the adiponectin/leptin ratio and osteocalcin in obese adolescents, indicating to ameliorate negative influence on bone turnover (Campos et al, 2018). Clinically, a study on SGLT2 inhibitors in obese non-diabetic individuals showed that remogliflozin etabonate significantly reduced the leptin/adiponectin ratio after 8 weeks (Napolitano et al, 2014).…”

Section: Effect Of T2dm and Sglt2 Inhibitors On Bone Metabolismmentioning

confidence: 99%

Effect of Sodium-Glucose Co-transporter 2 Inhibitors on Bone Metabolism and Fracture Risk

Zhao

Liang

et al. 2019

Front. Pharmacol.

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The effect of anti-diabetic medications on bone metabolism has received increasing attention, considering that type 2 diabetes mellitus is a common metabolic disorder with adverse effects on bone metabolism. Sodium-glucose co-transporter 2 (SGLT2) inhibitors are novel anti-diabetic medications that prevent glucose resorption at the proximal convoluted tubules in the kidney, increasing urinary glucose excretion, and decreasing the blood glucose level. The superiority of SGLT2 inhibitors shows in reducing the glucose level independent of insulin secretion, lowering the risk of hypoglycemia, and improving cardiovascular outcomes. SGLT2 inhibitors have been associated with genital mycotic infections, increased risk of acute kidney injury, dehydration, orthostatic hypotension, and ketoacidosis. Moreover, the effect of SGLT2 inhibitors on bone metabolism and fracture risk has been widely taken into consideration. Our review summarizes the results of current studies investigating the effects of SGLT2 inhibitors on bone metabolism (possibly including increased bone turnover, disrupted bone microarchitecture, and reduced bone mineral density). Several mechanisms are probably involved, such as bone mineral losses due to the disturbed calcium and phosphate homeostasis, as confirmed by an increase in fibroblast growth factor 23 and parathyroid hormone levels and a decrease in 1,25-dihydroxyvitamin D levels. SGLT2 inhibitors might indirectly increase bone turnover by weight loss. Lowering the blood glucose level might ameliorate bone metabolism impairment in diabetes. The effect of SGLT2 inhibitors on bone fractures remains unclear. Evidence indicating the direct effect of SGLT2 inhibitors on fracture risk is lacking and increased falls probably contribute to fractures.

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Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy

Cited by 16 publications

References 41 publications

Nutrient intake is a predictor of lung function in obese asthmatic adolescents undergoing interdisciplinary therapy

Nutrient intake is a predictor of lung function in obese asthmatic adolescents undergoing interdisciplinary therapy

The elusive clinical significance of osteocalcin actions in energy metabolism in humans

Effect of Sodium-Glucose Co-transporter 2 Inhibitors on Bone Metabolism and Fracture Risk

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