Metabolic syndrome components are associated with oxidative stress in overweight and obese patients

Morelli, Nayara Rampazzo; Scavuzzi, Bruna Miglioranza; Miglioranza, Lucia Helena da Silva; Lozovoy, Marcell Alysson Batisti; Simão, Andréa Name Colado; Dichi, Isaías

doi:10.20945/2359-3997000000036

Cited by 20 publications

(17 citation statements)

References 41 publications

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“…As previously mentioned, in terms of physiopathological mechanisms, a huge body of experimental studies, both in vitro and in vivo, suggests that variability in glucose, blood pressure, and uric acid levels favors an increase in oxidative stress, increasing the generation of free radicals (6,12,13,17,18); other mechanisms as possible triggers of diabetes complications deserve consideration (19)(20)(21)(22). On the other hand, in glucose-oscillating conditions, the intracellular antioxidant system seems to be less effective (23), and the protective antioxidant action of HDL cholesterol seems reduced if its levels are suboptimal and unstable over time (14).…”

Section: Discussionmentioning

confidence: 99%

“…The mechanisms underlying these findings are, at the moment, largely speculative. It should be argued that when these factors vary over time, they could favor an increase in oxidative stress, either increasing the generation of free radicals (glucose, blood pressure, plasma cholesterol, and uric acid) (6,12,13) or decreasing the defense against them (HDL) (14).…”

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confidence: 99%

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Overall Quality of Care Predicts the Variability of Key Risk Factors for Complications in Type 2 Diabetes: An Observational, Longitudinal Retrospective Study

et al. 2019

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OBJECTIVEAn association between variability in clinical parameters (HbA 1c , blood pressure, cholesterol, and uric acid) and risk of complications in type 2 diabetes has been reported. In this analysis, we investigated to what extent such variability is associated with overall quality of care. RESEARCH DESIGN AND METHODSThe quality of care summary score (Q-score) represents a validated, overall quality of care indicator ranging between 0 and 40; the higher the score, the better the quality of care provided by the diabetes center. We identified patients with five or more measurements of clinical parameters after the assessment of the Q-score. Multiple linear regression analyses assessed the role of the Q-score in predicting the variability of the different parameters. RESULTSOverall, 273,888 patients were analyzed. The variability of all the parameters systematically increased with decreasing Q-score values. At multivariate linear regression analysis, compared with a Q-score >25, a score <15 was associated with a significantly larger variation in HbA 1c , blood pressure, uric acid, total cholesterol, and LDL cholesterol and a lower variation in HDL cholesterol. The analysis of standardized b coefficients show that the Q-score has a larger impact on the variability of HbA 1c (0.34; P < 0.0001), systolic blood pressure (0.21; P < 0.0001), total cholesterol (0.21; P < 0.0001), and LDL cholesterol (0.20; P < 0.0001). CONCLUSIONSThe variability of risk factors for diabetic complications is associated with quality of care. Quality of care improvement initiatives should be targeted to increase the achievement of the recommended target while reducing such variability.In Italy, a continuous improvement effort implemented by a network of diabetes clinics, i.e., AMD (Associazone Medici Diabetologi) Annals, has been in place since 2006 (1,2). After 8 years from the launch of the initiative, half of the diabetes clinics in Italy participated in the AMD-Annals initiative, caring for over one-sixth of all diagnosed patients. Process and intermediate outcome measures consistently improved, in parallel with a more intensive and appropriate use of pharmacologic treatments (3).

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Overall Quality of Care Predicts the Variability of Key Risk Factors for Complications in Type 2 Diabetes: An Observational, Longitudinal Retrospective Study

et al. 2019

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“…Obesity and other associated pathologies are multifactorial disorders that are linked to the increase of ROS and NSS [99]. Obesity is a low-grade inflammatory condition that contributes to cardiovascular diseases, because adipose tissue produces and releases several proinflammatory mediators such as free fatty acids, interleukins and leptin [100].…”

Section: Obesitymentioning

confidence: 99%

Nitrosative Stress and Its Association with Cardiometabolic Disorders

et al. 2020

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Reactive nitrogen species (RNS) are formed when there is an abnormal increase in the level of nitric oxide (NO) produced by the inducible nitric oxide synthase (iNOS) and/or by the uncoupled endothelial nitric oxide synthase (eNOS). The presence of high concentrations of superoxide anions (O2−) is also necessary for their formation. RNS react three times faster than O2− with other molecules and have a longer mean half life. They cause irreversible damage to cell membranes, proteins, mitochondria, the endoplasmic reticulum, nucleic acids and enzymes, altering their activity and leading to necrosis and to cell death. Although nitrogen species are important in the redox imbalance, this review focuses on the alterations caused by the RNS in the cellular redox system that are associated with cardiometabolic diseases. Currently, nitrosative stress (NSS) is implied in the pathogenesis of many diseases. The mechanisms that produce damage remain poorly understood. In this paper, we summarize the current knowledge on the participation of NSS in the pathology of cardiometabolic diseases and their possible mechanisms of action. This information might be useful for the future proposal of anti-NSS therapies for cardiometabolic diseases.

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“…Besides the cardiometabolic alterations in obese people, endogenous antioxidant enzymes are not enough to neutralize the overproduction of reactive oxidative species [6], resulting in oxidative stress (OxS) and high levels of oxidation markers [7,8]. These alterations lead to dysregulated adipocytokine production, chronic inflammation, insulin resistance [9,10], and atherosclerotic lesion development [11].…”

Section: Introductionmentioning

confidence: 99%

Differential Effects of Agraz (<i>Vaccinium meridionale</i> Swartz) Consumption in Overweight and Obese Women with Metabolic Syndrome

Marín-Echeverri¹,

Piedrahita-Blandón²,

Galvis-Pérez³

et al. 2020

JFNR

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Obesity implies higher cardiovascular risk (CVR) than overweight. Polyphenol-rich fruits have shown to ameliorate CVR factors (CVRF). It is not clear whether differential effects could be observed between obese and overweight people consuming these fruits. Objective: To evaluate the effects of agraz on CVRF in overweight and obese women with metabolic syndrome (MetS). Methods: Overweight (n=22) and obese (n=18) women (25-60 years) with MetS, were included in this crossover, double-blind and placebo-controlled study. They consumed agraz or placebo over 4-weeks separated by a 4-wk washout period. At the end of each period, the following parameters were measured: anthropometrics, blood pressure, serum lipid profile, glucose, insulin, adipokines, apolipoprotein (apo)-A1, high sensitivity C-reactive protein (hs-CRP), serum total antioxidant capacity (TAC), endogenous antioxidant enzymes and oxidative stress (OxS) markers. Results: Compared to placebo, agraz consumption significantly (p<0.05) reduced hs-CRP and urinary 8-hydroxy 2 deoxyguanosine (8-OHdG) levels in overweight and obese women, respectively. In both groups, changes in antioxidant markers were significant (p<0.05) and negatively correlated with changes in CVR factors and OxS markers, respectively. Positive correlations were observed with cardioprotective markers. Conclusions: Agraz consumption had differential effects in overweight and obese women, with better effects on inflammation and OxS markers, respectively. Further studies should consider these differential responses when analyzing the results of an intervention, and eventually adjust to get better outcomes.

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Metabolic syndrome components are associated with oxidative stress in overweight and obese patients

Abstract: Nitrosative stress was related to BMI, and protein oxidation and nitrosative stress were related to metabolic changes and hypertension. MetS components were essential participants in oxidative and nitrosative stress in overweight and obese subjects.

Cited by 20 publications

References 41 publications

Overall Quality of Care Predicts the Variability of Key Risk Factors for Complications in Type 2 Diabetes: An Observational, Longitudinal Retrospective Study

Overall Quality of Care Predicts the Variability of Key Risk Factors for Complications in Type 2 Diabetes: An Observational, Longitudinal Retrospective Study

Nitrosative Stress and Its Association with Cardiometabolic Disorders

Differential Effects of Agraz (<i>Vaccinium meridionale</i> Swartz) Consumption in Overweight and Obese Women with Metabolic Syndrome

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