Impact of self-reported fasting duration on lipid profile variability, cardiovascular risk stratification and metabolic syndrome diagnosis

Janovsky, Carolina Castro Porto Silva; Laurinavicius, Antonio Gabriele; Cesena, Fernando Henpin Yue; Valente, Viviane A.; Ferreira, Carlos Eduardo; Mangueira, Cristóvão Luis Pitangueiras; Conceição, Raquel; Santos, Raul D.; Bittencourt, Márcio Sommer

doi:10.20945/2359-3997000000023

Cited by 2 publications

(3 citation statements)

References 18 publications

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“…Ideal fasting duration for lipid profile testing is 9 to 12 hours, while that for blood sugar is 6 to 8 hours. 8 When participants were asked question about lipid profile, only 74 replied correctly (35%), while most of them thought it is 6 to 8 hours, which is clearly inadequate fasting time for lipid profile.…”

Section: Resultsmentioning

confidence: 98%

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Questionnaire-based Study to Assess Knowledge of Preanalytical Phase of Laboratory Testing Among Trainee Doctors in a Tertiary Care Hospital Medical College

2020

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Objective To determine the knowledge base of common laboratory practices related to preanalytical phase of laboratory testing among medical interns and first-year postgraduate residents in a tertiary care hospital medical college. Materials and methods Questionnaire-based survey on preanalytical phase of laboratory testing was conducted among 208 participants, who volunteered and were MBBS interns and first-year postgraduate residents in a medical college, over the period from June 2018 to December 2019. A total of 15-item, multiple-choice questions (MCQs) were included, of which four were opinion-based and not considered for analysis. Responses were further categorized based on percentages with correct response, so we could identify specific knowledge points which need training. Statistical analysis Results were analyzed using Microsoft Excel functions and a simple calculator. Results A total of 208 participants were included in the study, which consisted of an equal number of interns (104) and first-year postgraduate residents (104). The term “preanalytical error” was known to 62.5% of participants. Only 9.62% participants took formal training in phlebotomy. Topics related to questions like coagulation testing, ideal fasting duration, mixing of blood, and order of draw received less than 40% correct response which meant that it requires more training. Conclusions In this era of evidence-based medicine, central laboratory plays a pivotal role in patient management, and quality of laboratory results are of paramount importance. Over a period of time, automation technology has reduced analytical phase errors to the minimum. Most errors reported are part of the preanalytical phase, and it has been found that a majority of them are committed due to a lack of knowledge and skills. In order to improve the preanalytical phase and make it as error-free as possible, the staff (technicians, nurses, and trainee doctors) should be constantly motivated and trained.

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Section: Resultsmentioning

confidence: 98%

“…Ideal fasting duration for lipid profile testing is 9 to 12 hours, while that for blood sugar is 6 to 8 hours. 8 Most of the participants (65%) thought fasting duration for lipid profile testing is 6 to 8 hours which is clearly inadequate. This can lead to falsely high-test results and unnecessary drug management.…”

Section: Discussionmentioning

confidence: 99%

Questionnaire-based Study to Assess Knowledge of Preanalytical Phase of Laboratory Testing Among Trainee Doctors in a Tertiary Care Hospital Medical College

2020

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“…For testing the lipid profile in clinical practice, overnight fasting or fasting for 8 to 12 h is conventionally recommended prior to blood collection to eliminate any interference from postprandial lipids, particularly triglycerides (TG) (3)(4)(5); in contrast, water and other calorie-and fat-free beverages are usually allowed (4,6). However, most individuals consume several meals during the day, and some consume snacks between meals, particularly in developed countries.…”

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confidence: 99%

Influence of Fasting Time on Serum and Hepatic Lipid Profiles in a Sprague-Dawley Rat Model of Nonalcoholic Steatohepatitis

Omagari

Uchida

Tagawa

et al. 2022

J Nutr Sci Vitaminol

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Nonalcoholic steatohepatitis (NASH) is associated with several cardiovascular risk factors, including atherogenic dyslipidemia. Recently, fasting prior to lipid profile evaluation has been thought to be unnecessary for most individuals. We investigated the impact of fasting for up to 9 h on the serum and hepatic lipid profiles in Sprague-Dawley (SD) rats of dietary-induced NASH model in comparison to SD rats fed a normal diet. In both groups, fasting affected the serum and hepatic triglyceride (TG), serum free fatty acid (FFA) and leptin levels, histopathologically assessed hepatocyte ballooning, and hepatic mRNA expression levels of several genes related to lipid metabolism. In contrast, the serum adiponectin and aminotransferase levels, serum and hepatic total cholesterol contents, and liver histopathological findings of hepatic steatosis, lobular inflammation and fibrosis were not influenced by fasting. A significant fasting time-dependent reduction was seen in the serum TG level only in the normal SD rats group. Regarding the hepatic TG level, a significant fasting time-dependent increase was seen only in the NASH model rat group. A significant fasting time-dependent reduction was also seen in the serum FFA level only in the NASH model rat group. Our present results indicate that excessive fasting can be avoided before blood or hepatic tissue sampling for the evaluation of several parameters in non-NASH and/or NASH model rats. Further investigations are needed in humans to determine whether excessive fasting before blood or hepatic tissue sampling can be avoided in both healthy individuals and NASH patients.

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Impact of self-reported fasting duration on lipid profile variability, cardiovascular risk stratification and metabolic syndrome diagnosis

Abstract: Self-reported fasting duration had no significant impact on the lipid profile results, including triglyceride levels. Consequently, no changes on the cardiovascular risk stratification using the Framingham risk score nor changes on the prevalence of metabolic syndrome were noted.

Cited by 2 publications

References 18 publications

Questionnaire-based Study to Assess Knowledge of Preanalytical Phase of Laboratory Testing Among Trainee Doctors in a Tertiary Care Hospital Medical College

Questionnaire-based Study to Assess Knowledge of Preanalytical Phase of Laboratory Testing Among Trainee Doctors in a Tertiary Care Hospital Medical College

Influence of Fasting Time on Serum and Hepatic Lipid Profiles in a Sprague-Dawley Rat Model of Nonalcoholic Steatohepatitis

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