Human venous blood derivatives as fetal bovine serum substitute for fibroblast culture cells in a fibrin construct
Luiz Alexandre Chisini,
Marcus Cristian Muniz Conde,
Sarah Arangurem Karam
et al.
Abstract:Aim: Venous blood derivatives (VBDs) have been suggested as substitutes for Fetal Bovine Serum (FBS) to improve the clinical transition of cell-based therapies. The literature is not clear about which is the best VBDs substitute. The present study aimed to evaluate the influence of VBDs on cell viability and describe a new method to seed these cells in a 3D Platelet-Rich Fibrin (PRF). Methods: Blood was processed to obtain Platelet-Poor Plasma from PRF (P-PRF), Human Serum (HS), Platelet-Poor Plasma from PRP (… Show more
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