“…Existing evidence strongly suggests that secretion of opiorphin in biological fluids increases as a response to painful stimuli, likely as a defense mechanism to increase the potency of innate anti‐nociceptive mechanisms. While some of these studies report a correlation between the opiorphin levels and the severity of the pain (Al‐Saffar et al, 2013; Ozdogan et al, 2019; Parida et al, 2018), majority of the studies report no correlation (Boucher et al, 2017; Dalirsani et al, 2023; Nejad et al, 2020; Ozdogan et al, 2020; Salarić et al, 2017). In our study, no significant correlation between the VAS scores and opiorphin levels was observed as well.…”