Analysis of the effect of in vitro dissolution on the pharmacokinetics of albendazole
Nelly Castro,
Iliana González-Hernández,
Lourdes Mayet-Cruz
et al.
Abstract:Albendazole is an anthelmintic drug commonly used in parenchymal neurocysticercosis and cystic echinococcosis. The aim of this study was to explore whether disparities in the dissolution profiles of albendazole products lead to significant differences in pharmacokinetic parameters. Three generic products and the innovator were evaluated in vitro. Quality control tests were performed, and dissolution profiles were obtained according to the Mexican Pharmacopeia. Although all products passed the quality control t… Show more
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